The role of enhancer of zeste homolog 2: From viral epigenetics to the carcinogenesis of hepatocellular carcinoma

12-O-tetradecanoylphorbol-13-acetate and EZH2 inhibition: A novel approach for promoting myogenic differentiation in embryonal rhabdomyosarcoma cells

(2017) Irene Marchesi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis

(2017) Shi-Lu Chen et al.   Molecular Oncology

Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens

(2017) Jesse H. Arbuckle et al.   mBio

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

(2017) Kien Nguyen et al.   mBio

Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma

(2017) Sufang Yang et al.   Oncology Letters

Epigenetics and Genetics of Viral Latency

(2016) Paul M. Lieberman   Cell Host & Microbe

Synthesis and Antineoplastic Evaluation of Novel Unsymmetrical 1,3,4-Oxadiazoles

(2016) Valentina Nieddu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Epigenetic balance of gene expression by Polycomb and COMPASS families

(2016) Andrea Piunti et al.   SCIENCE

Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma

(2016) Mankgopo M. Kgatle et al.   Biomed Research International

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

The Epigenetic Control of Hepatitis B Virus Modulates the Outcome of Infection

(2016) Lemonica Koumbi et al.   Frontiers in Microbiology

EZH2 phosphorylation regulates Tat-induced HIV-1 transactivation via ROS/Akt signaling pathway

(2015) Hong-Sheng Zhang et al.   FEBS LETTERS

EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors

(2015) Christine M. Fillmore et al.   NATURE

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

(2015) Kimberly H Kim et al.   NATURE MEDICINE

RNA polymerase II pausing during development

(2014) B. Gaertner et al.   DEVELOPMENT

Deregulation of miR-200b, miR-200c and miR-429 indicates its potential relevant role in patients with colorectal cancer liver metastasis

(2014) Ion Cristóbal et al.   JOURNAL OF SURGICAL ONCOLOGY

Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas

(2014) Sarah K. Knutson et al.   PLoS One

Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives

(2014) Li Ma   WORLD JOURNAL OF GASTROENTEROLOGY

Transcriptional Silencing by Polycomb-Group Proteins

(2014) U. Grossniklaus et al.   Cold Spring Harbor Perspectives in Biology

Regulation and Role of EZH2 in Cancer

(2014) Hirohito Yamaguchi et al.   Cancer Research and Treatment

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

(2013) Kyle D. Konze et al.   ACS Chemical Biology

MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity

(2013) Leibo Xu et al.   JOURNAL OF HEPATOLOGY

The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation

(2012) Irene Marchesi et al.   CELL CYCLE

Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1

(2012) F Rizzolio et al.   CELL DEATH AND DIFFERENTIATION

On the role of retinoblastoma family proteins in the establishment and maintenance of the epigenetic landscape

(2012) Francesco Paolo Fiorentino et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sputum analysis: Non-invasive early lung cancer detection

(2012) Vittorio D'Urso et al.   JOURNAL OF CELLULAR PHYSIOLOGY

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

(2012) Laura Belloni et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic Therapy Using Belinostat for Patients With Unresectable Hepatocellular Carcinoma: A Multicenter Phase I/II Study With Biomarker and Pharmacokinetic Analysis of Tumors From Patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group

(2012) Winnie Yeo et al.   JOURNAL OF CLINICAL ONCOLOGY

Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib

(2012) Anja Lachenmayer et al.   JOURNAL OF HEPATOLOGY

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

(2012) Sharad K. Verma et al.   ACS Medicinal Chemistry Letters

Virus strategies for passing the nuclear envelope barrier

(2012) Oren Kobiler et al.   Nucleus

Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells

(2011) Sung-Ok Kim et al.   BMB Reports

EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies

(2011) M.-Y. Cai et al.   GUT

Evolutionary diversity and developmental regulation of X-chromosome inactivation

(2011) Martin Escamilla-Del-Arenal et al.   HUMAN GENETICS

Carcinogenetic risk estimation based on quantification of DNA methylation levels in liver tissue at the precancerous stage

(2011) Ryo Nagashio et al.   INTERNATIONAL JOURNAL OF CANCER

Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma

(2011) Michael C Kew   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression

(2011) T. Fan et al.   MOLECULAR CANCER RESEARCH

Clinical significance of histone deacetylases 1, 2, 3, and 7: HDAC2 is an independent predictor of survival in HCC

(2011) Karl Quint et al.   VIRCHOWS ARCHIV

An overview of HCV molecular biology, replication and immune responses

(2011) Usman A Ashfaq et al.   Virology Journal

Hepatitis B virus X protein regulates the mEZH2 promoter via the E2F1-binding site in AML12 cells

(2011) Xiao-Yan Shi et al.   Chinese Journal of Cancer

DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8

(2010) Satoshi Kurita et al.   CANCER SCIENCE

Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma

(2010) Shintaro Iwata et al.   CANCER SCIENCE

DNA hypomethylation in cancer: Epigenetic scars of a neoplastic journey

(2010) Charles De Smet et al.   Epigenetics

Polycomb complexes act redundantly to repress genomic repeats and genes

(2010) M. Leeb et al.   GENES & DEVELOPMENT

Epidemiology and Management of Hepatocellular Carcinoma

(2010) Ju Dong Yang et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

The Etiology of Hepatocellular Carcinoma and Consequences for Treatment

(2010) A. J. Sanyal et al.   ONCOLOGIST

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic  -cell proliferation

(2009) S. Dhawan et al.   GENES & DEVELOPMENT

Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma

(2009) Yutaka Yonemitsu et al.   HUMAN PATHOLOGY

Control of cccDNA function in hepatitis B virus infection

(2009) Massimo Levrero et al.   JOURNAL OF HEPATOLOGY

Stem cell regulation by polycomb repressors: postponing commitment

(2008) Alexandra M Pietersen et al.   CURRENT OPINION IN CELL BIOLOGY

Chromatin organization and virus gene expression

(2008) Paul M. Lieberman   JOURNAL OF CELLULAR PHYSIOLOGY

Influenza A replication and host nuclear compartments: Many changes and many questions

(2008) L. Josset et al.   JOURNAL OF CLINICAL VIROLOGY

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED

(2008) Dina Rakotobe et al.   Virology Journal

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

(2008) Manching Ku et al.   PLoS Genetics