Cancer associated fibroblasts tailored tumor microenvironment of therapy resistance in gastrointestinal cancers

C-Met as a potential target for the treatment of gastrointestinal cancer: Current status and future perspectives

(2017) Afsane Bahrami et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of modern immunotherapy in gastrointestinal malignancies: a review of current clinical progress

(2017) Zin W. Myint et al.   Journal of Hematology & Oncology

The role of stromal cancer-associated fibroblasts in pancreatic cancer

(2017) Dagny von Ahrens et al.   Journal of Hematology & Oncology

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms

(2017) C Unger et al.   ONCOGENE

Fibroblast Activation Protein-α-Positive Fibroblasts Promote Gastric Cancer Progression and Resistance to Immune Checkpoint Blockade

(2017) Xuyang Wen et al.   ONCOLOGY RESEARCH

Roles of microRNAs in cancer associated fibroblasts of gastric cancer

(2017) Yu Yan et al.   PATHOLOGY RESEARCH AND PRACTICE

Metabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumors

(2017) Duojiao Wu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies

(2017) Guan-Zhong Qiu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway

(2017) Xiongyan Wu et al.   Oncotarget

Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment

(2017) Jeffrey Koury et al.   Stem Cells International

FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ERα-Positive Breast Cancer Cells

(2017) Lukasz Turczyk et al.   NEOPLASIA

CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors

(2017) Masayuki Ishibashi et al.   Scientific Reports

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

TGF-β signaling in liver and gastrointestinal cancers

(2016) L.H. Katz et al.   CANCER LETTERS

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors

(2016) Lucy Ireland et al.   CANCER RESEARCH

TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3

(2016) Rachel A. Hesler et al.   CARCINOGENESIS

Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

(2016) S. R. Hingorani et al.   CLINICAL CANCER RESEARCH

Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia

(2016) Xin Liu et al.   GENES & DEVELOPMENT

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer

(2016) Gemma Ferrer-Mayorga et al.   GUT

Comprehensively priming the tumor microenvironment by cancer-associated fibroblast-targeted liposomes for combined therapy with cancer cell-targeted chemotherapeutic drug delivery system

(2016) Binlong Chen et al.   JOURNAL OF CONTROLLED RELEASE

Galectin-1 from cancer-associated fibroblasts induces epithelial–mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer

(2016) Yang Chong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer-associated fibroblasts mediated chemoresistance by a FOXO1/TGFβ1 signaling loop in esophageal squamous cell carcinoma

(2016) Hongfang Zhang et al.   MOLECULAR CARCINOGENESIS

Targeting of cancer-associated fibroblasts enhances the efficacy of cancer chemotherapy by regulating the tumor microenvironment

(2016) MINMIN LI et al.   Molecular Medicine Reports

A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts

(2016) Binlong Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells

(2016) Y Deng et al.   ONCOGENE

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

(2016) Erik S. Knudsen et al.   Oncotarget

The application of the fibroblast activation protein α-targeted immunotherapy strategy

(2016) Guan-Min Jiang et al.   Oncotarget

Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

(2016) Eunice Yuen Ting Lau et al.   Cell Reports

Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer

(2016) Jiyoon Lee et al.   NEOPLASIA

Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment

(2016) B. L. Khoo et al.   Science Advances

Molecular mechanisms of chemoresistance in gastric cancer

(2016) Wen-Jia Shi et al.   World Journal of Gastrointestinal Oncology

Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts

(2015) Maria Peiris-Pagès et al.   Aging-US

Irradiated fibroblasts promote epithelial–mesenchymal transition and HDGF expression of esophageal squamous cell carcinoma

(2015) Ci-Hang Bao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Cancer-Associated Fibroblasts in Circulating Blood from Patients with Metastatic Breast Cancer

(2015) Z. Ao et al.   CANCER RESEARCH

PD-1 and PD-L1 blockade in gastrointestinal malignancies

(2015) Hazel Lote et al.   CANCER TREATMENT REVIEWS

miR-27 is associated with chemoresistance in esophageal cancer through transformation of normal fibroblasts to cancer-associated fibroblasts

(2015) Koji Tanaka et al.   CARCINOGENESIS

Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

(2015) C. Duluc et al.   EMBO Molecular Medicine

Caveolin-1 is a Modulator of Fibroblast Activation and a Potential Biomarker for Gastric Cancer

(2015) Xiao-Jun Shen et al.   International Journal of Biological Sciences

CD90+stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer

(2015) Phuong T. Huynh et al.   INTERNATIONAL JOURNAL OF CANCER

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

(2015) Daniel V.T. Catenacci et al.   JOURNAL OF CLINICAL ONCOLOGY

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

(2015) Charles K. Pallangyo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer

(2015) Vasiliki Koliaraki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment

(2015) F J Kohlhapp et al.   ONCOGENE

Role of cancer-associated fibroblasts in invasion and metastasis of gastric cancer

(2015) Yu Yan   WORLD JOURNAL OF GASTROENTEROLOGY

Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival

(2015) Zhi Zhao   WORLD JOURNAL OF GASTROENTEROLOGY

Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

(2015) Jean Albrengues et al.   Nature Communications

Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

(2015) Daoxiang Zhang et al.   Cell Reports

Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

(2015) Yibing Hu et al.   PLoS One

Combining Molecular Targeted Drugs to Inhibit Both Cancer Cells and Activated Stromal Cells in Gastric Cancer

(2015) Mieko Onoyama et al.   NEOPLASIA

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

(2014) Gvantsa Kharaishvili et al.   Cancer Cell International

Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs

(2014) S. Pennacchietti et al.   CANCER RESEARCH

MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors

(2014) Paolo Luraghi et al.   CANCER RESEARCH

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Loss of Stromal Caveolin-1 Expression: A Novel Tumor Microenvironment Biomarker That Can Predict Poor Clinical Outcomes for Pancreatic Cancer

(2014) Tao Shan et al.   PLoS One

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

(2014) Wan-Jiun Chen et al.   Nature Communications

Down-Regulation of Stromal Caveolin-1 Expression in Esophageal Squamous Cell Carcinoma: A Potent Predictor of Lymph Node Metastases, Early Tumor Recurrence, and Poor Prognosis

(2013) Yibin Jia et al.   ANNALS OF SURGICAL ONCOLOGY

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

(2013) Tania Fiaschi et al.   CELL CYCLE

Chemokine receptor CXCR4: Role in gastrointestinal cancer

(2013) Lucia Lombardi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Effects of the fibroblast activation protein on the invasion and migration of gastric cancer

(2013) Rui-Fen Wang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line

(2013) Yohei Funakoshi et al.   INVESTIGATIONAL NEW DRUGS

Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A

(2013) Fiorenza Lotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth

(2013) J. L. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Robo1 Signaling of Breast Cancer Cells by Slit2 from Stromal Fibroblast Restrains Tumorigenesis via Blocking PI3K/Akt/ -Catenin Pathway

(2012) P.-H. Chang et al.   CANCER RESEARCH

Roles of fibroblasts from the interface zone in invasion, migration, proliferation and apoptosis of gastric adenocarcinoma

(2012) Li-Hui Shan et al.   JOURNAL OF CLINICAL PATHOLOGY

The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilities

(2012) Michele De Palma et al.   Molecular Oncology

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression

(2012) Suzanne Ostrand-Rosenberg et al.   SEMINARS IN CANCER BIOLOGY

CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

(2012) Rosa Anna DeFilippis et al.   Cancer Discovery

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

CXCL12 (SDF1 )-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?

(2011) D. G. Duda et al.   CLINICAL CANCER RESEARCH

Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/ -catenin signalling pathway

(2011) L. Fu et al.   GUT

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP-Mediated Expression of HMGA2

(2010) S. Dangi-Garimella et al.   CANCER RESEARCH

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

(2010) Stephanos Pavlides et al.   CELL CYCLE

Malignant cells facilitate lung metastasis by bringing their own soil

(2010) D. G. Duda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment

(2009) Yongping Crawford et al.   CANCER CELL

P53 mutations in stromal fibroblasts sensitize tumors against chemotherapy

(2008) Daniel Lafkas et al.   INTERNATIONAL JOURNAL OF CANCER