LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues

An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential

(2014) Jonathan M. Goodwin et al.   MOLECULAR CELL

Automated analysis of invadopodia dynamics in live cells

(2014) Matthew E. Berginski et al.   PeerJ

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

(2013) Sourav Banerjee et al.   BIOCHEMICAL JOURNAL

Investigation of LKB1 Ser431phosphorylation and Cys433farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

(2013) Vanessa P. Houde et al.   BIOCHEMICAL JOURNAL

Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture

(2013) Julien Courchet et al.   CELL

The Hippo pathway polarizes the actin cytoskeleton during collective migration ofDrosophilaborder cells

(2013) Eliana P. Lucas et al.   JOURNAL OF CELL BIOLOGY

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

Clinicopathologic Correlations of Liver Kinase B1, E-Cadherin, and N-Cadherin Expression in Non–Small Cell Lung Cancer

(2013) Shuli Liu et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma

(2012) Wenjin Liu et al.   CANCER CELL

Enhanced antitumor effect of cisplatin in human NSCLC cells by tumor suppressor LKB1

(2012) W Ou et al.   CANCER GENE THERAPY

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis

(2012) Alejo E. Rodríguez-Fraticelli et al.   JOURNAL OF CELL BIOLOGY

Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways

(2012) Bryan Lo et al.   JOURNAL OF CELL BIOLOGY

LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap

(2012) H B Nguyen et al.   ONCOGENE

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

(2012) J. I. Partanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Microtubule Affinity Regulating Kinase Activity in Living Neurons Was Examined by a Genetically Encoded Fluorescence Resonance Energy Transfer/Fluorescence Lifetime Imaging-based Biosensor

(2011) Thomas Timm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarity-regulating Kinase Partitioning-defective 1b (PAR1b) Phosphorylates Guanine Nucleotide Exchange Factor H1 (GEF-H1) to Regulate RhoA-dependent Actin Cytoskeletal Reorganization

(2011) Yukie Yamahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MARK2/Par-1 guides the directionality of neuroblasts migrating to the olfactory bulb

(2011) Sheyla Mejia-Gervacio et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

(2010) Julian Carretero et al.   CANCER CELL

Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases

(2010) A. Marx et al.   FASEB JOURNAL

Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis

(2010) Erik R. Kline et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Site-specific Microtubule-associated Protein 4 Dephosphorylation Causes Microtubule Network Densification in Pressure Overload Cardiac Hypertrophy

(2010) Panneerselvam Chinnakkannu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LKB1 Regulated Pathways in Lung Cancer Invasion and Metastasis

(2010) Adam I. Marcus et al.   Journal of Thoracic Oncology

Somatic p16INK4a loss accelerates melanomagenesis

(2010) K B Monahan et al.   ONCOGENE

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

(2010) A. Zagorska et al.   Science Signaling

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Hepatocellular carcinoma development induced by conditional β-catenin activation inLkb1+/−mice

(2009) Hiroyuki Miyoshi et al.   CANCER SCIENCE

Conditional deletion of theLkb1gene in the mouse mammary gland induces tumour formation

(2009) Afshan McCarthy et al.   JOURNAL OF PATHOLOGY

Cdc42 and Rac Family GTPases Regulate Mode and Speed but Not Direction of Primary Fibroblast Migration during Platelet-Derived Growth Factor-Dependent Chemotaxis

(2009) J. Monypenny et al.   MOLECULAR AND CELLULAR BIOLOGY

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Somatic LKB1 Mutations Promote Cervical Cancer Progression

(2009) Shana N. Wingo et al.   PLoS One

SIK1 Couples LKB1 to p53-Dependent Anoikis and Suppresses Metastasis

(2009) H. Cheng et al.   Science Signaling

Loss of Lkb1 Provokes Highly Invasive Endometrial Adenocarcinomas

(2008) C. M. Contreras et al.   CANCER RESEARCH

Coronin 1B Antagonizes Cortactin and Remodels Arp2/3-Containing Actin Branches in Lamellipodia

(2008) Liang Cai et al.   CELL

Second-harmonic generation in collagen as a potential cancer diagnostic parameter

(2008) Tord Hompland et al.   JOURNAL OF BIOMEDICAL OPTICS

Accurate Balance of the Polarity Kinase MARK2/Par-1 Is Required for Proper Cortical Neuronal Migration

(2008) T. Sapir et al.   JOURNAL OF NEUROSCIENCE

Endothelial cell polarization and chemotaxis in a microfluidic device

(2008) Amir Shamloo et al.   LAB ON A CHIP

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

(2008) A. F. Hezel et al.   MOLECULAR AND CELLULAR BIOLOGY

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS