TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway

Reactive Oxygen Species-Mediated c-Jun NH 2 -Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction

(2017) Linmao Zhong et al.   JOURNAL OF VIROLOGY

Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells

(2017) Sharifah Syed Mortadza et al.   Scientific Reports

Transient receptor potential, Melastatin-2 (TRPM2) blockade: perspectives on potential novel clinical utility in cancer

(2017) Steven D. Blake et al.   Translational Cancer Research

Altered Mitochondrial Signalling and Metabolism in Cancer

(2017) Esita Chattopadhyay et al.   Frontiers in Oncology

Mechanistic study of TRPM2-Ca2+-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition

(2016) Qian Wang et al.   Autophagy

miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients

(2016) András Lánczky et al.   BREAST CANCER RESEARCH AND TREATMENT

Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents

(2016) Tiago Rodrigues et al.   CHEMICAL SOCIETY REVIEWS

Recent insights in the therapeutic management of patients with gastric cancer

(2016) Louis de Mestier et al.   DIGESTIVE AND LIVER DISEASE

Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics

(2016) Lei Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Mitochondria in Cancer Induction, Progression and Changes in Metabolism

(2016) Malgorzata Rogalinska   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Ovariectomy-Induced Mitochondrial Oxidative Stress, Apoptosis, and Calcium Ion Influx Through TRPA1, TRPM2, and TRPV1 Are Prevented by 17β-Estradiol, Tamoxifen, and Raloxifene in the Hippocampus and Dorsal Root Ganglion of Rats

(2016) Yener Yazğan et al.   MOLECULAR NEUROBIOLOGY

TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection

(2016) S Beceiro et al.   Mucosal Immunology

The TRPM2 ion channel is required for sensitivity to warmth

(2016) Chun-Hsiang Tan et al.   NATURE

Worldwide practice in gastric cancer surgery

(2016) Hylke JF Brenkman et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

(2016) Yajun He et al.   Oncotarget

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients

(2016) A. Marcell Szász et al.   Oncotarget

The overexpressed functional transient receptor potential channel TRPM2 in oral squamous cell carcinoma

(2016) Ling-Yan Zhao et al.   Scientific Reports

The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels

(2016) Hatice Akpınar et al.   Scientific Reports

Ion channel expression as promising cancer biomarker

(2015) Elena Lastraioli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

MAPK/JNK signaling: A potential autophagy regulation pathway

(2015) Yuan-Yuan Zhou et al.   BIOSCIENCE REPORTS

Broad-range TRP channel inhibitors (2-APB, flufenamic acid, SKF-96365) affect differently contraction of resistance and conduit femoral arteries of rat

(2015) Michal Bencze et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of the transient receptor potential melastatin-2 channel causes increased DNA damage and decreased proliferation in breast adenocarcinoma cells

(2015) MANDI M. HOPKINS et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review)

(2015) HUA-FU ZHAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia

(2015) M.-K. Chung et al.   NEUROSCIENCE

Enhanced cytotoxicity in triple-negative and estrogen receptor-positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel

(2015) DAVID W. KOH et al.   ONCOLOGY REPORTS

Cancer stemness and progression: mitochondria on the stage

(2015) Paola Chiarugi et al.   Oncotarget

TRPM2 Channel-Mediated ROS-Sensitive Ca2+ Signaling Mechanisms in Immune Cells

(2015) Sharifah Alawieyah Syed Mortadza et al.   Frontiers in Immunology

Review article: the epidemiology and prevention of gastric cancer

(2014) K. M. Fock   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Autophagy promotesBrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism

(2014) Anne M Strohecker et al.   Autophagy

Involvement of cAMP/EPAC/TRPM2 Activation in Glucose- and Incretin-Induced Insulin Secretion

(2014) M. Yosida et al.   DIABETES

Gastric Cancer-Epidemiologic and Clinical Aspects

(2014) Marino Venerito et al.   HELICOBACTER

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury

(2014) Barbara A. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2α

(2014) Shu-jen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antisense transcription at the TRPM2 locus as a novel prognostic marker and therapeutic target in prostate cancer

(2014) U Orfanelli et al.   ONCOGENE

Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways

(2014) JIA LIU et al.   ONCOLOGY REPORTS

Upregulation of Autophagy-Related Gene-5 (ATG-5) Is Associated with Chemoresistance in Human Gastric Cancer

(2014) Jie Ge et al.   PLoS One

MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway

(2014) Yongqiang Dong et al.   TUMOR BIOLOGY

PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

(2014) L Chang et al.   Cell Death & Disease

Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-Driven Cancers

(2014) A. M. Strohecker et al.   Cancer Discovery

Role of TRPM2 in cell proliferation and susceptibility to oxidative stress

(2013) Shu-jen Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells

(2013) Ann-Jeng Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Gastric Cancer: Epidemiologic Aspects

(2013) Carlos A. González et al.   HELICOBACTER

A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy

(2013) W He et al.   ONCOGENE

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

The role of ion channels and transporters in cell proliferation and cancer

(2013) Andrea Becchetti et al.   Frontiers in Physiology

Augmented autophagy pathways and MTOR modulation in fibroblasts from long-lived mutant mice

(2012) Min Wang et al.   Autophagy

Cell Death and Autophagy under Oxidative Stress: Roles of Poly(ADP-Ribose) Polymerases and Ca2+

(2012) P. Wyrsch et al.   MOLECULAR AND CELLULAR BIOLOGY

Putative TRP channel antagonists, SKF 96365, flufenamic acid and 2-APB, are non-competitive antagonists at recombinant human α1β2γ2 GABAA receptors

(2012) M.G. Rae et al.   NEUROCHEMISTRY INTERNATIONAL

The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis

(2012) R A Veldhoen et al.   ONCOGENE

TRP channels: diagnostic markers and therapeutic targets for breast cancer?

(2012) Halima Ouadid-Ahidouch et al.   TRENDS IN MOLECULAR MEDICINE

JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure

(2012) A H Chaanine et al.   Cell Death & Disease

Postoperative chemotherapy in gastric cancer, consisting of etoposide, doxorubicin and cisplatin, followed by radiotherapy with concomitant cisplatin: A feasibility study

(2012) KATERINA SHULMAN et al.   Oncology Letters

TRP Channels and Cancer: New Targets for Diagnosis and Chemotherapy

(2012) Giorgio Santoni et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Role of Autophagy in Cancer Prevention

(2011) Hsin-Yi Chen et al.   Cancer Prevention Research

JNK regulates FoxO-dependent autophagy in neurons

(2011) P. Xu et al.   GENES & DEVELOPMENT

Sulfur mustard primes human neutrophils for increased degranulation and stimulates cytokine release via TRPM2/p38 MAPK signaling

(2011) Hwa-Yong Ham et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TRPM2 modulates insulin secretion in pancreatic β-cells

(2011) Kunitoshi Uchida et al.   Islets

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice

(2010) K. Uchida et al.   DIABETES

TRPM2 channel properties, functions and therapeutic potentials

(2010) Lin-Hua Jiang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

State-dependent Inhibition of TRPM2 Channel by Acidic pH

(2010) Wei Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification

(2010) John G. Starkus et al.   JOURNAL OF PHYSIOLOGY-LONDON

HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells

(2010) L Liu et al.   LEUKEMIA

Involvement of JNK in the regulation of autophagic cell death

(2010) S Shimizu et al.   ONCOGENE

Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications

(2009) Jin-Qiang Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras

(2009) Joo-Yun Byun et al.   CARCINOGENESIS

Paclitaxel chemotherapy for the treatment of gastric cancer

(2009) Junichi Sakamoto et al.   Gastric Cancer

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in   Cells

(2009) I. Lange et al.   Science Signaling

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils

(2008) Ingo Lange et al.   CELL CALCIUM

Identification of novel sense and antisense transcription at the TRPM2 locus in cancer

(2008) Ugo Orfanelli et al.   CELL RESEARCH

Current strategies in systemic treatment of gastric cancer and cancer of the gastroesophageal junction

(2008) Markus Menges et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Screening for gastric cancer in Asia: current evidence and practice

(2008) Wai K Leung et al.   LANCET ONCOLOGY

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

(2008) D-D Li et al.   ONCOGENE