The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint

Using ‘swallow-tail’ sign and putaminal hypointensity as biomarkers to distinguish multiple system atrophy from idiopathic Parkinson’s disease: A susceptibility-weighted imaging study

(2017) Na Wang et al.   EUROPEAN RADIOLOGY

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Iron Deposition Leads to Neuronal α-Synuclein Pathology by Inducing Autophagy Dysfunction

(2017) Wenbin Wan et al.   Frontiers in Neurology

Serial Susceptibility Weighted MRI Measures Brain Iron and Microbleeds in Dementia

(2017) Wolff Kirsch et al.   JOURNAL OF ALZHEIMERS DISEASE

Iron and dopamine: a toxic couple

(2016) Dominic J. Hare et al.   BRAIN

Multiple system atrophy: pathogenic mechanisms and biomarkers

(2016) Kurt A. Jellinger et al.   JOURNAL OF NEURAL TRANSMISSION

In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan

(2016) J. Acosta-Cabronero et al.   JOURNAL OF NEUROSCIENCE

Review: Multiple system atrophy: emerging targets for interventional therapies

(2016) N. Stefanova et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein

(2016) N. L. Rey et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome

(2016) J.D. Mills et al.   NEUROSCIENCE

The putaminal abnormalities on 3.0T magnetic resonance imaging: can they separate parkinsonism-predominant multiple system atrophy from Parkinson's disease?

(2015) Jie-ying Feng et al.   ACTA RADIOLOGICA

Differentiation of Parkinsonism-Predominant Multiple System Atrophy from Idiopathic Parkinson Disease Using 3T Susceptibility-Weighted MR Imaging, Focusing on Putaminal Change and Lesion Asymmetry

(2015) I. Hwang et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Ceruloplasmin activity and iron chelation treatment of patients with Parkinson’s disease

(2015) Guillaume Grolez et al.   BMC Neurology

Differentiating multiple-system atrophy from Parkinson's disease

(2015) N. Ramli et al.   CLINICAL RADIOLOGY

‘Ride on the ferrous wheel’ – The cycle of iron in macrophages in health and disease

(2015) Manfred Nairz et al.   IMMUNOBIOLOGY

Significance of the hot-cross bun sign on T2*-weighted MRI for the diagnosis of multiple system atrophy

(2015) Kazushi Deguchi et al.   JOURNAL OF NEUROLOGY

Progression of subcortical atrophy and iron deposition in multiple system atrophy: a comparison between clinical subtypes

(2015) Jae-Hyeok Lee et al.   JOURNAL OF NEUROLOGY

Putaminal hypointensity on T2*-weighted MR imaging is the most practically useful sign in diagnosing multiple system atrophy: A preliminary study

(2015) Atsuhiko Sugiyama et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The relation between α-synuclein and microglia in Parkinson’s disease: Recent developments

(2015) V. Sanchez-Guajardo et al.   NEUROSCIENCE

The utility of susceptibility-weighted imaging for differentiating Parkinsonism-predominant multiple system atrophy from Parkinson’s disease: Correlation with 18F-flurodeoxyglucose positron-emission tomography

(2015) Ra Gyoung Yoon et al.   NEUROSCIENCE LETTERS

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation

(2015) Bruno Di Marco Vieira et al.   Frontiers in Cellular Neuroscience

α-Synuclein as a ferrireductase

(2015) David R. Brown   BIOCHEMICAL SOCIETY TRANSACTIONS

Susceptibility-Weighted Imaging Improves the Diagnostic Accuracy of 3T Brain MRI in the Work-Up of Parkinsonism

(2014) F.J.A. Meijer et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Neuropathology of multiple system atrophy: New thoughts about pathogenesis

(2014) Kurt A. Jellinger   MOVEMENT DISORDERS

Iron and multiple sclerosis

(2014) James M. Stankiewicz et al.   NEUROBIOLOGY OF AGING

Copper and Copper Proteins in Parkinson’s Disease

(2014) Sergio Montes et al.   Oxidative Medicine and Cellular Longevity

An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

(2014) Dominic J. Hare et al.   Chemical Science

Hepcidin antagonists for potential treatments of disorders with hepcidin excess

(2014) Maura Poli et al.   Frontiers in Pharmacology

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Alpha-synuclein transfers from neurons to oligodendrocytes

(2013) Juan F. Reyes et al.   GLIA

Quantitative assessment of subcortical atrophy and iron content in progressive supranuclear palsy and parkinsonian variant of multiple system atrophy

(2013) Jae-Hyeok Lee et al.   JOURNAL OF NEUROLOGY

A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats

(2013) Chia Chi Sun et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mammalian iron metabolism and its control by iron regulatory proteins

(2012) Cole P. Anderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanistic analysis of iron accumulation by endothelial cells of the BBB

(2012) Ryan C. McCarthy et al.   BIOMETALS

Hyperintense putaminal rim at 1.5 T: prevalence in normal subjects and distinguishing features from multiple system atrophy

(2012) Khin K Tha et al.   BMC Neurology

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Topographical differences of brain iron deposition between progressive supranuclear palsy and parkinsonian variant multiple system atrophy

(2012) Yong-Hee Han et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?

(2012) Carla M. Lema Tomé et al.   MOLECULAR NEUROBIOLOGY

Iron dysregulation in movement disorders

(2012) Petr Dusek et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein expression is modulated at the translational level by iron

(2012) Fabia Febbraro et al.   NEUROREPORT

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies

(2012) Haya Kisos et al.   PLoS One

Impairment of Interrelated Iron- and Copper Homeostatic Mechanisms in Brain Contributes to the Pathogenesis of Neurodegenerative Disorders

(2012) Tina Skjørringe et al.   Frontiers in Pharmacology

Phosphorylation of α-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson’s Disease and Related Disorders

(2011) Yu Lu et al.   ACS Chemical Neuroscience

Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

(2011) Lisa Fellner et al.   ACTA NEUROPATHOLOGICA

Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging

(2011) Y. Wang et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

H-ferritin is the major source of iron for oligodendrocytes

(2011) Bozho Todorich et al.   GLIA

The role of endocytic pathways in cellular uptake of plasma non-transferrin iron

(2011) Y.-S. Sohn et al.   HAEMATOLOGICA

The alpha-synuclein 5′untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen

(2011) Jack T. Rogers et al.   JOURNAL OF NEURAL TRANSMISSION

Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging

(2011) George Bartzokis et al.   NEUROPSYCHOPHARMACOLOGY

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

(2011) Lydia Alvarez-Erviti et al.   NEUROSCIENCE RESEARCH

Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Iron Uptake Mediated by Binding of H-Ferritin to the TIM-2 Receptor in Mouse Cells

(2011) Jian Han et al.   PLoS One

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update

(2010) Kurt A. Jellinger et al.   ACTA NEUROPATHOLOGICA

Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

(2010) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: An in vivo MR study

(2010) Jiuquan Zhang et al.   BRAIN RESEARCH

Rescuing iron-overloaded macrophages by conservative relocation of the accumulated metal

(2010) Yang-Sung Sohn et al.   BRITISH JOURNAL OF PHARMACOLOGY

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Transient Expression of Iron Transport Proteins in the Capillary of the Developing Rat Brain

(2010) W. M. Yang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

Brain iron metabolism and its perturbation in neurological diseases

(2010) Robert R. Crichton et al.   JOURNAL OF NEURAL TRANSMISSION

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

Putaminal magnetic resonance imaging features at various magnetic field strengths in multiple system atrophy

(2010) Hirohisa Watanabe et al.   MOVEMENT DISORDERS

Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis

(2010) J. J. Gagne et al.   NEUROLOGY

Utility of susceptibility-weighted MRI in differentiating Parkinson’s disease and atypical parkinsonism

(2010) Deepak Gupta et al.   NEURORADIOLOGY

Iron in the Brain

(2010) John L. Beard et al.   NUTRITION REVIEWS

Cerebellar Lesions in Multiple System Atrophy: Postmortem MR Imaging−Pathologic Correlations

(2009) E. Matsusue et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitro

(2009) J.M. Dean et al.   BRAIN BEHAVIOR AND IMMUNITY

Physiological and Pathological Role of Alpha-synuclein in Parkinson’s Disease Through Iron Mediated Oxidative Stress; The Role of a Putative Iron-responsive Element

(2009) David Olivares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Binding of α-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes

(2009) Yong Peng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV  -Synucleinopathy

(2009) C. Y. Chung et al.   JOURNAL OF NEUROSCIENCE

Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins

(2009) Tracey A. Rouault et al.   METABOLIC BRAIN DISEASE

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Brain iron homeostasis and neurodegenerative disease

(2009) E. E. Benarroch   NEUROLOGY

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

(2009) Xiaomin Su et al.   NEUROTOXICITY RESEARCH

[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

(2009) A.L. Bartels et al.   PARKINSONISM & RELATED DISORDERS

Age-related Iron Deposition in the Basal Ganglia: Quantitative Analysis in Healthy Subjects

(2009) Domenico Aquino et al.   RADIOLOGY

Intracellular Chemical Imaging of the Developmental Phases of Human Neuromelanin Using Synchrotron X-ray Microspectroscopy

(2008) Sylvain Bohic et al.   ANALYTICAL CHEMISTRY

Multiple system atrophy: A primary oligodendrogliopathy

(2008) Gregor K. Wenning et al.   ANNALS OF NEUROLOGY

Clearance and deposition of extracellular α-synuclein aggregates in microglia

(2008) He-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ceruloplasmin in neurodegenerative diseases

(2008) Sarah J. Texel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Iron, the substantia nigra and related neurological disorders

(2008) Amanda M. Snyder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Iron Regulatory Proteins Are Essential for Intestinal Function and Control Key Iron Absorption Molecules in the Duodenum

(2008) Bruno Galy et al.   Cell Metabolism

Metals in Alzheimer's and Parkinson's Diseases

(2008) Kevin J Barnham et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Microglial cells and Parkinson’s disease

(2008) Li Qian et al.   IMMUNOLOGIC RESEARCH

Tim-2 is the receptor for H-ferritin on oligodendrocytes

(2008) Bozho Todorich et al.   JOURNAL OF NEUROCHEMISTRY

Nitrated Alpha-Synuclein and Microglial Neuroregulatory Activities

(2008) Ashley D. Reynolds et al.   Journal of Neuroimmune Pharmacology

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

The role of iron dysregulation in the pathogenesis of multiple sclerosis: an Egyptian study

(2008) N Abo-Krysha et al.   Multiple Sclerosis Journal

Second consensus statement on the diagnosis of multiple system atrophy

(2008) S. Gilman et al.   NEUROLOGY

Putaminal lesion in multiple system atrophy: postmortem MR-pathological correlations

(2008) Eiji Matsusue et al.   NEURORADIOLOGY

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

(2005) Alessandra Gaeta et al.   BRITISH JOURNAL OF PHARMACOLOGY