Article
Pharmacology & Pharmacy
Mehrdad Alikhani, Mahdi Aalikhani, Masoumeh Khalili
Summary: This study investigated the effects of several natural compounds on iron-overload in the heart and found that hesperidin, vanillin, and ferulic acid were the most effective antioxidant compounds, improving the activity of antioxidant enzymes and reducing iron deposition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mehrdad Jahanshahi, Masoumeh Khalili, Asra Margedari
Summary: The study showed that naringin has a strong iron chelation capacity leading to a decrease in nonheme iron content and a reduction in amyloid plaque formation in the hippocampus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Nik Krajnc, Gabriel Bsteh, Gregor Kasprian, Tobias Zrzavy, Barbara Kornek, Thomas Berger, Fritz Leutmezer, Paulus Rommer, Hans Lassmann, Simon Hametner, Assunta Dal-Bianco
Summary: This study did not find an association between hemolysis parameters and iron rim lesions, despite a significant association between these parameters and markers for neurodegeneration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
David Devos, Julien Labreuche, Olivier Rascol, Jean-Christophe Corvol, Alain Duhamel, P. Guyon Delannoy, Werner Poewe, Yaroslau Compta, Nicola Pavese, Evzen Ruzicka, Petr Dusek, Bart Post, Bastiaan R. Bloem, Daniela Berg, Walter Maetzler, Markus Otto, Marie-Odile Habert, Stephane Lehericy, Joaquim Ferreira, Richard Dodel, Christine Tranchant, Alexandre Eusebio, Stephane Thobois, Ana-Raquel Marques, Wassilios G. Meissner, Fabienne Ory-Magne, Uwe Walter, Rob M. A. de Bie, Miguel Gago, Dolores Vilas, Jaime Kulisevsky, Cristina Januario, Miguel V. S. Coelho, Stefanie Behnke, Paul Worth, Klaus Seppi, Thavarak Ouk, Camille Potey, Celine Leclercq, Romain Viard, Gregory Kuchcinski, Renaud Lopes, Jean-Pierre Pruvo, Pascal Pigny, Guillaume Garcon, Ophelie Simonin, Jessica Carpentier, Anne-Sophie Rolland, Dag Nyholm, Christoph Scherfler, Jean-Francois Mangin, Marie Chupin, Regis Bordet, David T. Dexter, Caroline Fradette, Michael Spino, Fernando Tricta, Scott Ayton, Ashley I. Bush, Jean-Christophe Devedjian, James A. Duce, Ioav Cabantchik, Luc Defebvre, Dominique Deplanque, Caroline Moreau
Summary: In a 36-week trial involving participants with early Parkinson's disease who had not received levodopa, treatment with the iron chelator deferiprone led to worse scores in measures of parkinsonism compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Neurosciences
Belinda Fouche, Stephanie Turner, Rebecca Gorham, Eloise J. Stephenson, Simon Gutbier, Joanna L. Elson, Olimpo Garcia-Beltran, Francois H. van der Westhuizen, Ilse S. Pienaar
Summary: This study demonstrates the neuroprotective potential of a new polyhydroxyl coumarin, CT51, against the mitochondrial toxin MPP+. CT51 preserves neural function and circuitry against PD-related damage by targeting cell bodies and axons, restoring somatic cell viability and neurite processes. Additionally, CT51 acts as an antioxidant agent and downregulates the expression of HIF-1 alpha, providing further protection against oxidative stress.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mihai Lupu, Camelia Alexandra Coada, Diana -Valentina Tudor, Ioana Baldea, Adrian Florea, Vlad -Alexandru Toma, Ana Lupsor, Remus Moldovan, Nicoleta Decea, Gabriela Adriana Filip
Summary: Iron dysmetabolism is common in heart failure patients, especially those with reduced ejection fraction. Chronic hypertension, a common risk factor for heart failure and death, is associated with iron deficiency. Iron deposition in organs can cause oxidative stress and cell death. In a rat model of cardiac hypertrophy induced by pressure overload, iron chelation with deferiprone reduced inflammation, lipid peroxidation, mitochondrial iron levels, and hypertrophy. This suggests that iron redistribution, particularly in mitochondria, may have beneficial effects in the cardiovascular system.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Nastaran Moinipour, Mahdi Barati, Amirhossein Sahebkar, Milad Iranshahy, Abolfazl Shakeri
Summary: Iron overload can cause damage to various organs, but using curcumin as a chelator can help remove excess iron and potentially treat iron overload.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Carson Essenburg, Richard W. Browne, Diala Ghazal, Miriam Tamano-Blanco, Dejan Jakimovski, Bianca Weinstock-Guttman, Robert Zivadinov, Murali Ramanathan
Summary: This study investigated the changes in antioxidant enzyme activities in multiple sclerosis (MS) patients over a 5-year follow-up period and found that these activities did not significantly change in MS patients, but increased in healthy controls. The differences were modest and antioxidant enzyme activities were not associated with disability in MS patients. Rating: 7/10.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Y. Campos Espinosa, Chibuike C. Udenigwe, Apollinaire Tsopmo
Summary: This study found that oat bran protein hydrolysates have antioxidant and bile acid-binding properties, which are important for preventing chronic diseases and stabilizing food quality.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Neurosciences
Jack A. Reeves, Niels Bergsland, Michael G. Dwyer, Gregory E. Wilding, Dejan Jakimovski, Fahad Salman, Balint Sule, Nicklas Meineke, Bianca Weinstock-Guttman, Robert Zivadinov, Ferdinand Schweser
Summary: Brain iron homeostasis is crucial for brain function, and changes in brain iron levels have been observed in patients with multiple sclerosis. Independent Component Analysis (ICA) can be used to study the independent processes regulating iron levels.
Article
Clinical Neurology
Assunta Dal-Bianco, Guenther Grabner, Claudia Kronnerwetter, Michael Weber, Barbara Kornek, Gregor Kasprian, Thomas Berger, Fritz Leutmezer, Paulus Stefan Rommer, Siegfried Trattnig, Hans Lassmann, Simon Hametner
Summary: Iron rim lesions in multiple sclerosis patients signify a more severe disease course and propensity to develop progressive disease. Long-term follow-up reveals different dynamics of iron rim lesions in relapsing-remitting versus progressive disease, with potential implications for disease progression and brain damage.
Article
Biotechnology & Applied Microbiology
Raphaela Santos-Tierno, Renata Garcia, Eduardo Fonseca, Fabio Faleiro, Davyson Moreira, Georgia Pacheco, Elisabeth Mansur
Summary: The induction of calluses from Passiflora species is influenced by light quality, with bioactive compounds being modulated by the dedifferentiation process. Different LED lights can affect biomass accumulation and production of metabolites, with blue LED inducing the highest production of bioactive substances. The study highlights the importance of lighting conditions in in vitro systems for potential applications in biotechnology and pharmaceutical industries.
PLANT CELL TISSUE AND ORGAN CULTURE
(2021)
Article
Biochemistry & Molecular Biology
Anna Bizon, Justyna Chojdak-Lukasiewicz, Aleksandra Koltuniuk, Slawomir Budrewicz, Anna Pokryszko-Dragan, Agnieszka Piwowar
Summary: This study evaluated oxidative stress parameters in the serum of patients with relapsing-remitting multiple sclerosis (RRMS), and found associations between these parameters and clinical/laboratory markers. AOPP and FRAP concentrations were higher in male patients. There were correlations between AOPP and inflammation markers, and differences in AOPP among subgroups receiving different treatments.
Article
Neurosciences
P. Sorrentino, S. Petkoski, M. Sparaco, E. Troisi Lopez, E. Signoriello, F. Baselice, S. Bonavita, M. A. Pirozzi, M. Quarantelli, G. Sorrentino, V. Jirsa
Summary: Two structurally connected brain regions are more likely to interact, with the properties of the structural bundles and the topology of the structural connectome affecting the timing of the interactions. Using magneto/electroencephalography (MEG/EEG) and integrating them with the structural bundles, researchers measured functional delays across the entire human brain and created a topochronic map. The study also found that patients with multiple sclerosis had greater delays across the network compared to controls.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Bruce E. Holbein, Christian Lehmann
Summary: Iron is essential for various biological processes but can be toxic in excess. Dysregulation of iron metabolism has been linked to a range of diseases, including infections, cancer, and neurological disorders. Current therapies for iron dysregulation have limitations, but new iron chelators and hepcidin agonists show promise. Harnessing iron-driven reactive oxygen species generation and ferroptosis may offer selective cancer cell destruction. This review discusses iron requirements, regulation, and dysregulation in diseases, as well as potential new therapies.
Article
Multidisciplinary Sciences
Asaff Harel, Antonia Ceccarelli, Colleen Farrell, Michelle Fabian, Jonathan Howard, Claire Riley, Aaron Miller, Fred Lublin, Matilde Inglese
Editorial Material
Cardiac & Cardiovascular Systems
Antonio Sorgente, Antonia Ceccarelli, Riccardo Cappato
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2013)
Article
Clinical Neurology
Eric C. Klawiter, Antonia Ceccarelli, Ashish Arora, Jonathan Jackson, Sonya Bakshi, Gloria Kim, Jennifer Miller, Shahamat Tauhid, Christian von Gizycki, Rohit Bakshi, Mohit Neema
JOURNAL OF NEUROIMAGING
(2015)
Article
Clinical Neurology
Elisa Dell'Oglio, Antonia Ceccarelli, Bonnie I. Glanz, Brian C. Healy, Shahamat Tauhid, Ashish Arora, Nikila Saravanan, Matthew J. Bruha, Alexander V. Vartanian, Sheena L. Dupuy, Ralph H. B. Benedict, Rohit Bakshi, Mohit Neema
JOURNAL OF NEUROIMAGING
(2015)
Review
Geriatrics & Gerontology
Neal D. Barnard, Ashley I. Bush, Antonia Ceccarelli, James Cooper, Celeste A. de Jager, Kirk I. Erickson, Gary Fraser, Shelli Kesler, Susan M. Levin, Brendan Lucey, Martha Clare Morris, Rosanna Squitti
NEUROBIOLOGY OF AGING
(2014)
Article
Neurosciences
Rohit Bakshi, Mohit Neema, Shahamat Tauhid, Brian C. Healy, Bonnie I. Glanz, Gloria Kim, Jennifer Miller, Julia L. Berkowitz, Riley Bove, Maria K. Houtchens, Christopher Severson, James M. Stankiewicz, Lynn Stazzone, Tanuja Chitnis, Charles R. G. Guttmann, Howard L. Weiner, Antonia Ceccarelli
Article
Multidisciplinary Sciences
Michele Cavallari, Antonia Ceccarelli, Guang-Yi Wang, Nicola Moscufo, Salem Hannoun, Christina R. Matulis, Jonathan S. Jackson, Bonnie I. Glanz, Rohit Bakshi, Mohit Neema, Charles R. G. Guttmann
Article
Clinical Neurology
Antonia Ceccarelli, Victoria Mifsud, Eslam Abusamra, Syed Irteza Hussain
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Antonia Ceccarelli, Victoria Ann Mifsud, Amna Dogar, Syed Irteza Hussain
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Antonia Ceccarelli, Victoria Ann Mifsud, Amna Dogar
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Article
Microbiology
Christophe de Terwangne, Jabber Laouni, Lionel Jouffe, Jerome R. Lechien, Vincent Bouillon, Sammy Place, Lucio Capulzini, Shahram Machayekhi, Antonia Ceccarelli, Sven Saussez, Antonio Sorgente
Meeting Abstract
Clinical Neurology
J. Akhtar, A. Ceccarelli
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2019)
Meeting Abstract
Clinical Neurology
Antonia Ceccarelli, Victoria Mifsud, Rawan Yasser Gaber Elhennawy, Beatrice Benedetti, Syed Hussain, Stephen Samples
Meeting Abstract
Clinical Neurology
Shahamat Tauhid, Mohit Neema, Antonia Ceccarelli, Brian Healy, Ashish Arora, Howard Weiner, Rohit Bakshi
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
