Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer’s Disease

(2017) Per Johansson et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL

(2017) Arturo I. Machuca-Parra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular cholesterol homeostasis and Alzheimer’s disease

(2017) Ta-Yuan Chang et al.   JOURNAL OF LIPID RESEARCH

Collagenosis of the Deep Medullary Veins: An Underrecognized Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction?

(2017) Julia Keith et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Brain Perfusion and Diffusion Abnormalities in Children Treated for Posterior Fossa Brain Tumors

(2017) Matthew D. Li et al.   JOURNAL OF PEDIATRICS

Relationship between cognitive function and regulation of cerebral blood flow

(2017) Shigehiko Ogoh   Journal of Physiological Sciences

Systemic inflammation and alterations to cerebral blood flow in obstructive sleep apnea

(2017) Hsiu-Ling Chen et al.   JOURNAL OF SLEEP RESEARCH

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study

(2017) Simon F. Eskildsen et al.   NEUROBIOLOGY OF AGING

CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients

(2017) Tobias Skillbäck et al.   NEUROBIOLOGY OF AGING

Vascular Contributions to Cognitive Impairment in Late Life

(2017) Helena C. Chui et al.   NEUROLOGIC CLINICS

Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer’s disease

(2017) Nan Zhang et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Nutrition in Stroke Prevention

(2017) J. Spence   SEMINARS IN NEUROLOGY

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease

(2016) Raj N. Kalaria   ACTA NEUROPATHOLOGICA

The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: A multicentre, randomized, double-blind, placebo-controlled trial

(2016) Jianping Jia et al.   Alzheimers & Dementia

Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI-Tuscany Study

(2016) Emilia Salvadori et al.   Alzheimers & Dementia

Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID)

(2016) Atticus H. Hainsworth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel imaging techniques in cerebral small vessel diseases and vascular cognitive impairment

(2016) Gargi Banerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Is the time ripe for new diagnostic criteria of cognitive impairment due to cerebrovascular disease? Consensus report of the International Congress on Vascular Dementia working group

(2016) Robert Perneczky et al.   BMC Medicine

Neuroimaging in vascular cognitive impairment: a state-of-the-art review

(2016) Wolf-Dieter Heiss et al.   BMC Medicine

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment

(2016) Olivia A. Skrobot et al.   BRAIN

Frontal Assessment Battery as a Useful Tool to Differentiate Mild Cognitive Impairment due to Subcortical Ischemic Vascular Disease from Alzheimer Disease

(2016) Yen-Hsuan Hsu et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort

(2016) Olivia Anna Skrobot et al.   JOURNAL OF ALZHEIMERS DISEASE

Neural Basis of Apathy in Patients with Amnestic Mild Cognitive Impairment

(2016) Hiroaki Kazui et al.   JOURNAL OF ALZHEIMERS DISEASE

Magnetic resonance imaging for assessment of cerebrovascular reactivity in cerebral small vessel disease: A systematic review

(2016) Gordon W Blair et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral blood flow in small vessel disease: A systematic review and meta-analysis

(2016) Yulu Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition

(2016) Lilah M. Besser et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Meta-analysis of apolipoprotein E levels in the cerebrospinal fluid of patients with Alzheimer's disease

(2016) Puneet Talwar et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL, and healthy brains

(2016) Fiyyaz Ahmed-Jushuf et al.   NEUROBIOLOGY OF AGING

Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias

(2016) Aiqing Chen et al.   NEUROBIOLOGY OF AGING

Advanced magnetic resonance imaging of neurodegenerative diseases

(2016) Federica Agosta et al.   NEUROLOGICAL SCIENCES

Early- vs late-onset subcortical vascular cognitive impairment

(2016) Young Kyoung Jang et al.   NEUROLOGY

Cortical cerebral microinfarcts on 3T MRI

(2016) Saima Hilal et al.   NEUROLOGY

Progression of small vessel disease correlates with cortical thinning in Parkinson’s disease

(2016) Heidi Foo et al.   PARKINSONISM & RELATED DISORDERS

Cerebral Blood Flow Alterations as Assessed by 3D ASL in Cognitive Impairment in Patients with Subcortical Vascular Cognitive Impairment: A Marker for Disease Severity

(2016) Yawen Sun et al.   Frontiers in Aging Neuroscience

Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits

(2016) Rita Moretti et al.   Frontiers in Aging Neuroscience

Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: A longitudinal arterial spin labeling study

(2016) Elise G.P. Dopper et al.   NeuroImage-Clinical

The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey

(2015) Martina Bocchetta et al.   Alzheimers & Dementia

Brain FDG PET and the Diagnosis of Dementia

(2015) Veeresh K. N. Shivamurthy et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1

(2015) Jung Min Ha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Brief Memory and Executive Test (BMET) for detecting vascular cognitive impairment in small vessel disease: a validation study

(2015) Rebecca L Brookes et al.   BMC Medicine

Differential relationships between apathy and depression with white matter microstructural changes and functional outcomes

(2015) Matthew J. Hollocks et al.   BRAIN

Cerebrospinal fluid tau and amyloid-β1-42in patients with dementia

(2015) Tobias Skillbäck et al.   BRAIN

Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation

(2015) Li-Hua Zhu et al.   CLINICAL SCIENCE

Consensus statement for diagnosis of subcortical small vessel disease

(2015) Gary A Rosenberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood and CSF biomarkers in brain subcortical ischemic vascular disease: Involved pathways and clinical applicability

(2015) A Vilar-Bergua et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alzheimer’s disease—subcortical vascular disease spectrum in a hospital-based setting: Overview of results from the Gothenburg MCI and dementia studies

(2015) Anders Wallin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cardiovascular risk factors and small vessel disease of the brain: Blood pressure, white matter lesions, and functional decline in older persons

(2015) Hazel Mae A Abraham et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Water Exchange across the Blood-Brain Barrier in Obstructive Sleep Apnea: An MRI Diffusion-Weighted Pseudo-Continuous Arterial Spin Labeling Study

(2015) Jose A. Palomares et al.   JOURNAL OF NEUROIMAGING

The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment

(2015) Geon Ha Kim et al.   JOURNAL OF NEUROLOGY

Validation of biomarkers in subcortical ischaemic vascular disease of the Binswanger type: approach to targeted treatment trials

(2015) G. A. Rosenberg et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Brain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936

(2015) Simon R. Cox et al.   NEUROBIOLOGY OF AGING

A neuroradiologist’s guide to arterial spin labeling MRI in clinical practice

(2015) M. Grade et al.   NEURORADIOLOGY

Chronic obstructive pulmonary disease and cerebrovascular disease: A comprehensive review

(2015) Lies Lahousse et al.   RESPIRATORY MEDICINE

What are White Matter Hyperintensities Made of? Relevance to Vascular Cognitive Impairment

(2015) Joanna M. Wardlaw et al.   Journal of the American Heart Association

Cerebral Small Vessel Disease and Chronic Kidney Disease

(2015) Kazunori Toyoda   Journal of Stroke

MCI of different etiologies differ on the Cognitive Assessment Battery

(2014) O. Nyström et al.   ACTA NEUROLOGICA SCANDINAVICA

Diagnostic Criteria for Vascular Cognitive Disorders

(2014) Perminder Sachdev et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Hydrocephalus Decreases Arterial Spin-Labeled Cerebral Perfusion

(2014) K.W. Yeom et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

Microvascular Pathology and Morphometrics of Sporadic and Hereditary Small Vessel Diseases of the Brain

(2014) Lucinda J.L. Craggs et al.   BRAIN PATHOLOGY

Age-Associated White Matter Lesions: The MRC Cognitive Function and Ageing Study

(2014) Stephen B. Wharton et al.   BRAIN PATHOLOGY

Cerebral Amyloid Angiopathy, Subcortical White Matter Disease and Dementia: Literature Review and Study in OPTIMA

(2014) Margaret Esiri et al.   BRAIN PATHOLOGY

Retinopathy and Progression of CKD: The CRIC Study

(2014) J. E. Grunwald et al.   Clinical Journal of the American Society of Nephrology

Blood-Brain Barrier Dysfunction and Cerebral Small Vessel Disease (Arteriolosclerosis) in Brains of Older People

(2014) Leslie R. Bridges et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The neuropsychological profile of vascular cognitive impairment not demented: A meta-analysis

(2014) Brandon P. Vasquez et al.   Journal of Neuropsychology

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia

(2014) David C. Alsop et al.   MAGNETIC RESONANCE IN MEDICINE

Plasma lipids and cerebral small vessel disease

(2014) S. Schilling et al.   NEUROLOGY

Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden

(2014) J. Staals et al.   NEUROLOGY

Hippocampal volume and white matter disease in the prediction of dementia in Parkinson's disease

(2014) Nagaendran Kandiah et al.   PARKINSONISM & RELATED DISORDERS

CSF Biomarkers and Neuropsychological Profiles in Patients with Cerebral Small-Vessel Disease

(2014) Peter Hermann et al.   PLoS One

Cerebral Subcortical Small Vessel Disease in Subjects With Pathologically Confirmed Alzheimer Disease

(2013) Margaret M. Esiri et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Do Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) progress differently?

(2013) Yun Jeong Hong et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Deterioration of Gait and Balance over Time: The Effects of Age-Related White Matter Change - The LADIS Study

(2013) Stefan H. Kreisel et al.   CEREBROVASCULAR DISEASES

Association of fasting glucose with subclinical cerebrovascular disease in older adults without Type 2 diabetes

(2013) R. C. Sims et al.   DIABETIC MEDICINE

Brief Screening for Mild Cognitive Impairment in Subcortical Ischemic Vascular Disease: A Comparison Study of the Montreal Cognitive Assessment with the Mini-Mental State Examination

(2013) Qun Xu et al.   EUROPEAN NEUROLOGY

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Cerebrospinal fluid biomarkers in Alzheimer’s disease, vascular dementia and ischemic stroke patients: a critical analysis

(2013) Lisa Kaerst et al.   JOURNAL OF NEUROLOGY

Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010

(2013) Valery L Feigin et al.   LANCET

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments

(2013) Hee Jin Kim et al.   NEUROBIOLOGY OF AGING

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

(2013) Sharon C Yates et al.   Acta Neuropathologica Communications

Metabolic syndrome and localization of white matter hyperintensities in the elderly population

(2012) Florence Portet et al.   Alzheimers & Dementia

Contribution of Neuroimaging to the Diagnosis of Alzheimer’s Disease and Vascular Dementia

(2012) Gustavo Román et al.   ARCHIVES OF MEDICAL RESEARCH

Neurobehavioral Dysfunction in Patients with Subcortical Vascular Mild Cognitive Impairment and Subcortical Vascular Dementia

(2012) Juhee Chin et al.   CLINICAL NEUROPSYCHOLOGIST

EFNS task force: the use of neuroimaging in the diagnosis of dementia

(2012) M. Filippi et al.   EUROPEAN JOURNAL OF NEUROLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Hereditary cerebral small vessel diseases: A review

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Role of Peripheral Inflammatory Markers in Dementia and Alzheimer's Disease: A Meta-Analysis

(2012) A. Koyama et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

White Matter Lesion Progression in LADIS

(2012) Reinhold Schmidt et al.   STROKE

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Cerebrovascular Consequences of Obstructive Sleep Apnea

(2012) David J. Durgan et al.   Journal of the American Heart Association

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Protecting against vascular disease in brain

(2011) Frank M. Faraci   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Mini-Mental State Examination and Montreal Cognitive Assessment in Persons With Mild Subacute Stroke: Relationship to Functional Outcome

(2011) Joan Toglia et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Average Daily Blood Pressure, Not Office Blood Pressure, Is Associated With Progression of Cerebrovascular Disease and Cognitive Decline in Older People

(2011) William B. White et al.   CIRCULATION

The Microvasculature in Chronic Kidney Disease

(2011) Q. L. Ooi et al.   Clinical Journal of the American Society of Nephrology

Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes

(2011) Emma L. Jones et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) study

(2011) Seong Hye Choi et al.   NEUROLOGICAL SCIENCES

Genetic associations with brain microbleeds: Systematic review and meta-analyses

(2011) S. S. Maxwell et al.   NEUROLOGY

Neuropathologic evidence of endothelial changes in cerebral small vessel disease

(2011) M. O. Giwa et al.   NEUROLOGY

Cerebral subcortical small vessel disease and its relation to cognition in elderly subjects: a pathological study in the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort

(2011) A. Smallwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

Genome-Wide Association Study of Vascular Dementia

(2011) Elisabeth M.C. Schrijvers et al.   STROKE

Association of intronic sequence variant in the gene encoding spleen tyrosine kinase with susceptibility to vascular dementia

(2011) Younyoung Kim et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

(2010) A. A. Gouw et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The relationship between blood pressure and cognitive function

(2010) Vera Novak et al.   Nature Reviews Cardiology

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Longitudinal Cognitive Decline in Subcortical Ischemic Vascular Disease – The LADIS Study

(2009) Hanna Jokinen et al.   CEREBROVASCULAR DISEASES

Subcortical Vascular Dementia Biomarker Pattern in Mild Cognitive Impairment

(2009) Maria Bjerke et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in Alzheimer’s disease

(2009) Chi-Wei Huang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Genetic Determinants of White Matter Hyperintensities on Brain Scans

(2009) Lavinia Paternoster et al.   STROKE

Living Beyond Our Physiological Means

(2009) Charlie S. Thompson et al.   STROKE

Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History

(2009) Carole Dufouil et al.   STROKE

Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology

(2008) A. A. Gouw et al.   BRAIN

Metabolic Syndrome and Risk for Incident Alzheimer's Disease or Vascular Dementia: The Three-City Study

(2008) C. Raffaitin et al.   DIABETES CARE

The Metabolic Syndrome

(2008) Marc-Andre Cornier et al.   ENDOCRINE REVIEWS

CSF biomarker profile and diagnostic value in vascular dementia

(2008) G. P. Paraskevas et al.   EUROPEAN JOURNAL OF NEUROLOGY

Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions

(2008) Hirokazu Bokura et al.   STROKE

Role of the renin–angiotensin system in vascular inflammation

(2008) Chiara Marchesi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pulse Pressure and Pulse Wave Velocity Are Related to Cognitive Decline in the Baltimore Longitudinal Study of Aging

(2007) Shari R. Waldstein et al.   HYPERTENSION

Behavioural and psychological symptoms are not related to white matter hyperintensities and medial temporal lobe atrophy in Alzheimer's disease

(2007) Salka S. Staekenborg et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Cerebral small vessel disease and C-reactive protein: Results of a cross-sectional study in community-based Japanese elderly

(2007) Manabu Wada et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

CSF cortisol in Alzheimer's disease and mild cognitive impairment

(2007) Julius Popp et al.   NEUROBIOLOGY OF AGING

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING

Action of Glucocorticoids on Survival of Nerve Cells: Promoting Neurodegeneration or Neuroprotection?1

(2003) I. M. Ábrahám et al.   JOURNAL OF NEUROENDOCRINOLOGY