Tau Conformation as a Target for Disease-Modifying Therapy: The Role of Truncation

Tauons and Prions: Infamous Cousins?

(2018) Petr Novak et al.   JOURNAL OF ALZHEIMERS DISEASE

Hyperphosphorylated Truncated Protein Tau Induces Caspase-3 Independent Apoptosis-Like Pathway in the Alzheimer's Disease Cellular Model

(2018) Monika Zilkova et al.   JOURNAL OF ALZHEIMERS DISEASE

Intracellular Degradation of Misfolded Tau Protein Induced by Geldanamycin is Associated with Activation of Proteasome

(2018) Alena Opattova et al.   JOURNAL OF ALZHEIMERS DISEASE

Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study

(2018) Teodoro del Ser et al.   JOURNAL OF ALZHEIMERS DISEASE

Stress-Induced Activation of the Sympathoadrenal System is Determined by Genetic Background in Rat Models of Tauopathy

(2018) Katarina Lejavova et al.   JOURNAL OF ALZHEIMERS DISEASE

N-terminal Truncation of Microtubule Associated Protein Tau Dysregulates its Cellular Localization

(2018) Kristina Paholikova et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Expression of Truncated Tau Efficiently Promotes Neurodegeneration in Animal Models: Pitfalls of Toxic Oligomer Analysis

(2017) Rostislav Skrabana et al.   JOURNAL OF ALZHEIMERS DISEASE

Changes of Cerebrospinal Fluid Peptides due to Tauopathy

(2017) Petra Majerova et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

(2017) Youssra K. Al-Hilaly et al.   JOURNAL OF MOLECULAR BIOLOGY

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

(2017) Petr Novak et al.   LANCET NEUROLOGY

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications

(2017) Yiming Lei et al.   PROGRESS IN NEUROBIOLOGY

A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

(2017) Susanne Ostrowitzki et al.   Alzheimers Research & Therapy

Metabolic status of CSF distinguishes rats with tauopathy from controls

(2017) Radana Karlíková et al.   Alzheimers Research & Therapy

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

(2016) Marie K. Bondulich et al.   BRAIN

Introduction to Protein Ensembles and Allostery

(2016) Ruth Nussinov   CHEMICAL REVIEWS

Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy

(2016) Ivana Zimova et al.   JOURNAL OF ALZHEIMERS DISEASE

Pharmacological Agents Targeting γ-Secretase Increase Risk of Cancer and Cognitive Decline in Alzheimer’s Disease Patients: A Systematic Review and Meta-Analysis

(2016) Ross Penninkilampi et al.   JOURNAL OF ALZHEIMERS DISEASE

Tauopathy in transgenic (SHR72) rats impairs function of central noradrenergic system and promotes neuroinflammation

(2016) Boris Mravec et al.   Journal of Neuroinflammation

Quantitative analysis of phenylalanine, tyrosine, tryptophan and kynurenine in rat model for tauopathies by ultra-high performance liquid chromatography with fluorescence and mass spectrometry detection

(2016) Jaroslav Galba et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

Co-expression of truncated and full-length tau induces severe neurotoxicity

(2016) S Ozcelik et al.   MOLECULAR PSYCHIATRY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

(2016) YoungDoo Kim et al.   NEUROBIOLOGY OF DISEASE

The phenotypic spectrum of progressive supranuclear palsy

(2016) G. Respondek et al.   PARKINSONISM & RELATED DISORDERS

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

(2016) Tong Li et al.   Nature Communications

Clinicopathologic and11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum

(2015) Melissa E. Murray et al.   BRAIN

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Human secreted tau increases amyloid-beta production

(2015) Jessica Bright et al.   NEUROBIOLOGY OF AGING

Invited review: Prion-like transmission and spreading of tau pathology

(2015) Florence Clavaguera et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Truncated tau deregulates synaptic markers in rat model for human tauopathy

(2015) Santosh Jadhav et al.   Frontiers in Cellular Neuroscience

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

(2015) Maxime Derisbourg et al.   Scientific Reports

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease

(2014) Ludovic Collin et al.   BRAIN

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

(2014) V. Melis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Homocysteine in Rat Plasma: Application to the Study of a Rat Model for Tauopathies

(2014) A. Kovac et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam

(2014) M. Arif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s disease

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

Multisteric Regulation by Structural Disorder in Modular Signaling Proteins: An Extension of the Concept of Allostery

(2013) Peter Tompa   CHEMICAL REVIEWS

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Effects of Davunetide on N-acetylaspartate and Choline in Dorsolateral Prefrontal Cortex in Patients with Schizophrenia

(2013) L Fredrik Jarskog et al.   NEUROPSYCHOPHARMACOLOGY

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

(2013) Clara Theunis et al.   PLoS One

Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease

(2013) Jere E. Meredith Jr. et al.   PLoS One

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid chromatography–tandem mass spectrometry method for determination of panel of neurotransmitters in cerebrospinal fluid from the rat model for tauopathy

(2013) Andrej Kovac et al.   TALANTA

The self-perpetuating tau truncation circle

(2012) Norbert Zilka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation

(2012) G. Nübling et al.   EXPERIMENTAL NEUROLOGY

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

(2012) Norbert Zilka et al.   Journal of Neuroinflammation

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study

(2012) Jennifer L Whitwell et al.   LANCET NEUROLOGY

TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells

(2012) D. P. Fitzgerald et al.   MOLECULAR CANCER THERAPEUTICS

Neuropathological background of phenotypical variability in frontotemporal dementia

(2011) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Truncation of tau at E391 Promotes Early Pathologic Changes in Transgenic Mice

(2011) Pamela J. McMillan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

First transgenic rat model developing progressive cortical neurofibrillary tangles

(2011) Peter Filipcik et al.   NEUROBIOLOGY OF AGING

Classification of primary progressive aphasia and its variants

(2011) M. L. Gorno-Tempini et al.   NEUROLOGY

Tau Truncation is a Productive Posttranslational Modification of Neurofibrillary Degeneration in Alzheimers Disease

(2010) B. Kovacech et al.   Current Alzheimer Research

Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease

(2010) Zuzana Stozicka et al.   Journal of Neuroinflammation

Transition of Tau Protein from Disordered to Misordered in Alzheimer’s Disease

(2010) Branislav Kovacech et al.   Neurodegenerative Diseases

Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies

(2009) Norbert Zilka et al.   ACTA NEUROPATHOLOGICA

Truncated tau expression levels determine life span of a rat model of tauopathy without causing neuronal loss or correlating with terminal neurofibrillary tangle load

(2008) Peter Koson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE

NeuroScale, the battery of behavioral tests with novel scoring system for phenotyping of transgenic rat model of tauopathy

(2008) Miroslava Korenova et al.   JOURNAL OF NEUROSCIENCE METHODS