ORMDL3 and its implication in inflammatory disorders

Neuronal autophagy and intercellular regulation of homeostasis in the brain

(2018) Aditi Kulkarni et al.   CURRENT OPINION IN NEUROBIOLOGY

Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca 2+ oscillations in asthma

(2018) Jun Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms and roles by which IRF-3 mediates the regulation of ORMDL3 transcription in respiratory syncytial virus infection

(2017) Xiao-Hua Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer

(2017) Sanguine Byun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α–Endoplasmic Reticulum Stress–Beclin1 Autophagy Regulatory Pathway

(2017) Jie Dang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate

(2017) Marina Miller et al.   JOURNAL OF IMMUNOLOGY

Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation

(2017) Dae Jin Song et al.   JOURNAL OF IMMUNOLOGY

ORMDL3 is associated with airway remodeling in asthma via the ERK/MMP-9 pathway

(2017) Fei Yu et al.   Molecular Medicine Reports

Upregulation of miR-665 promotes apoptosis and colitis in inflammatory bowel disease by repressing the endoplasmic reticulum stress components XBP1 and ORMDL3

(2017) Manying Li et al.   Cell Death & Disease

A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

(2017) Fang Qiu et al.   Nature Communications

Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis

(2017) Yuki Hitomi et al.   Scientific Reports

The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma

(2016) T. Paulenda et al.   ALLERGY

Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells

(2015) Viktor Bugajev et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

E3 ubiquitin ligase Cbl-b suppresses human ORMDL3 expression through STAT6 mediation

(2015) Wei-Xia Yang et al.   FEBS LETTERS

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis

(2015) Deanna Siow et al.   JOURNAL OF LIPID RESEARCH

ORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells

(2015) Xiaochun Ma et al.   Scientific Reports

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

(2014) Nathalie Acevedo et al.   HUMAN MOLECULAR GENETICS

Coordinated Regulation of the Orosomucoid-like Gene Family Expression Controlsde NovoCeramide Synthesis in Mammalian Cells

(2014) Kerstin Kiefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma

(2014) M. Miller et al.   JOURNAL OF IMMUNOLOGY

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress

(2013) Eveline Hoefkens et al.   Autophagy

Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression

(2013) Rongfang Qiu et al.   FEBS Journal

All-Trans Retinoic Acid Modulates ORMDL3 Expression via Transcriptional Regulation

(2013) Li-Li Zhuang et al.   PLoS One

Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population

(2013) R Qiu et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

(2013) Sung Gil Ha et al.   Nature Communications

Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12

(2012) Fina A.S. Kurreeman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ORMDL3 modulates store-operated calcium entry and lymphocyte activation

(2012) Amado Carreras-Sureda et al.   HUMAN MOLECULAR GENETICS

Mechanisms elevating ORMDL3 expression in recurrent wheeze patients: Role of Ets-1, p300 and CREB

(2012) Rui Jin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mammalian ORMDL Proteins Mediate the Feedback Response in Ceramide Biosynthesis

(2012) Deanna L. Siow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

(2012) M. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population

(2011) Rongfang Qiu et al.   BMC Medical Genetics

Characterization of a novel isoform of the human ORMDL3 gene

(2011) Rui Jin et al.   CELL AND TISSUE RESEARCH

Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze

(2011) E V Bräuner et al.   GENES AND IMMUNITY

New IBD genetics: common pathways with other diseases

(2011) C. W. Lees et al.   GUT

A sequence variant on 17q21 is associated with age at onset and severity of asthma

(2010) Eva Halapi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Allergy and glioma risk: Test of association by genotype

(2010) Sara E. Dobbins et al.   INTERNATIONAL JOURNAL OF CANCER

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Asthma and atopy are associated with chromosome 17q21 markers in Chinese children

(2009) T. F. Leung et al.   ALLERGY

Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma

(2009) H. Wu et al.   ALLERGY

Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease

(2009) Dominique J. Verlaan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

17q21 variants modify the association between early respiratory infections and asthma

(2009) L. A. M. Smit et al.   EUROPEAN RESPIRATORY JOURNAL

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

(2009) Gerard Cantero-Recasens et al.   HUMAN MOLECULAR GENETICS

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry

(2009) James H. Flory et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ORMDL3Gene Is Associated with Asthma in Three Ethnically Diverse Populations

(2008) Joshua Galanter et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry

(2008) Patrick M.A. Sleiman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications

(2008) Roger Tavendale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population

(2007) Tomomitsu Hirota et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY