期刊
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
卷 21, 期 6, 页码 1154-1162出版社
WILEY
DOI: 10.1111/1756-185X.13324
关键词
apoptosis; autophagy; endoplasmic reticulum stress; inflammation; lipid metabolism; ORMDL3; polymorphism
类别
资金
- Shandong Province Science and Technology Development Plan [2014GGH218016]
- Natural Science Foundation of Shandong Province [ZR2017BH017, ZR2018BH002]
- Natural Science Foundation of China [81560273, 81500375]
A growing body of evidence has suggested the genetic association of ORMDL3 gene (ORMDL Sphingolipid Biosynthesis Regulator 3) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL3 gene expression in inflammation. This mini-review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL3 in common inflammatory disorders.
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