Complement Activation in Liver Transplantation: Role of Donor Macrosteatosis and Implications in Delayed Graft Function

A phase I/II, double-blind, placebo-controlled study assessing safety and efficacy of C1 esterase inhibitor for prevention of delayed graft function in deceased donor kidney transplant recipients

(2018) Stanley C. Jordan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

OPTN/SRTR 2016 Annual Data Report: Liver

(2018) W. R. Kim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

STIM1 deficiency protects the liver from ischemia/reperfusion injury in mice

(2018) Yanyang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A prospective randomized, controlled trial of eculizumab to prevent ischemia-reperfusion injury in pediatric kidney transplantation

(2018) Michael Kaabak et al.   PEDIATRIC TRANSPLANTATION

Natural immunoglobulin M initiates an inflammatory response important for both hepatic ischemia reperfusion injury and regeneration in mice

(2017) Keely Marshall et al.   HEPATOLOGY

Complement-mediated inflammation and injury in brain dead organ donors

(2017) Felix Poppelaars et al.   MOLECULAR IMMUNOLOGY

Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease

(2016) Tim Hendrikx et al.   BMC Medicine

The complement component C5 promotes liver steatosis and inflammation in murine non-alcoholic liver disease model

(2016) Lorena Bavia et al.   IMMUNOLOGY LETTERS

Excellent outcomes of liver transplantation using severely steatotic grafts from brain-dead donors

(2016) Tiffany C. L. Wong et al.   LIVER TRANSPLANTATION

Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis

(2016) Perinur Bozaykut et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application

(2016) George Hajishengallis et al.   SEMINARS IN IMMUNOLOGY

The role of extended criteria donors in liver transplantation for nonalcoholic steatohepatitis

(2016) Francesca M. Dimou et al.   SURGERY

Post reperfusion syndrome during liver transplantation: From pathophysiology to therapy and preventive strategies

(2016) Antonio Siniscalchi   WORLD JOURNAL OF GASTROENTEROLOGY

Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia–reperfusion injury

(2016) Q Zhao et al.   Cell Death & Disease

Serum complement C3 levels are associated with nonalcoholic fatty liver disease independently of metabolic features in Chinese population

(2016) Chengfu Xu et al.   Scientific Reports

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Donor Hepatic Steatosis and Outcome After Liver Transplantation: a Systematic Review

(2015) Michael J. J. Chu et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Mitochondrial dysfunction in steatotic rat livers occurs because a defect in complex i makes the liver susceptible to prolonged cold ischemia

(2015) Michael J. J. Chu et al.   LIVER TRANSPLANTATION

Donor Hepatic Steatosis Induce Exacerbated Ischemia-Reperfusion Injury Through Activation of Innate Immune Response Molecular Pathways

(2015) Ricardo C. Gehrau et al.   TRANSPLANTATION

Hypoxia and Complement-and-Coagulation Pathways in the Deceased Organ Donor as the Major Target for Intervention to Improve Renal Allograft Outcome

(2015) Jeffrey Damman et al.   TRANSPLANTATION

A Phase I/II Placebo-Controlled Trial of C1-Inhibitor for Prevention of Antibody-Mediated Rejection in HLA Sensitized Patients

(2015) Ashley A. Vo et al.   TRANSPLANTATION

Steroid Anti-Inflammatory Effects Did Not Improve Organ Quality in Brain-Dead Rats

(2015) Rolando A. Rebolledo et al.   Biomed Research International

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

The occurrence of postreperfusion syndrome in orthotopic liver transplantation and its significance in terms of complications and short-term survival

(2015) Barbara Bukowicka et al.   Annals of Transplantation

Association between Complement C3 and Prevalence of Fatty Liver Disease in an Adult Population: A Cross-Sectional Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study

(2015) Qiyu Jia et al.   PLoS One

ATF6 Mediates a Pro-Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia-Reperfusion Injury

(2014) J. Rao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Immunoglobulin M, C-Reactive Protein and Complement Activation in Rat Hepatic Ischemia-Reperfusion Injury

(2014) Gwendolyn M.P. Diepenhorst et al.   EUROPEAN SURGICAL RESEARCH

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies

(2014) Dimitrios Tsiantoulas et al.   JOURNAL OF LIPID RESEARCH

Prednisolone has a positive effect on the kidney but not on the liver of brain dead rats: a potencial role in complement activation

(2014) Rolando Rebolledo et al.   Journal of Translational Medicine

Elevated sensitivity of macrosteatotic hepatocytes to hypoxia/reoxygenation stress is reversed by a novel defatting protocol

(2014) Nir I. Nativ et al.   LIVER TRANSPLANTATION

Effect of pure microsteatosis on transplant outcomes after living donor liver transplantation: A matched case-control study

(2014) Sangbin Han et al.   LIVER TRANSPLANTATION

Complement Alternative Pathway Activation in Human Nonalcoholic Steatohepatitis

(2014) Filip M. Segers et al.   PLoS One

Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease

(2014) Xue-Qun Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner

(2013) Netanya Y. Spencer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

Safe use of highly steatotic livers by utilizing a donor/recipient clinical algorithm

(2013) Kenneth D. Chavin et al.   CLINICAL TRANSPLANTATION

Activated complement factor 3 is associated with liver fat and liver enzymes: the CODAM study

(2013) Nick Wlazlo et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

TIFA upregulation after hypoxia–reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release

(2013) Ning Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice

(2013) Gary W. Nace et al.   HEPATOLOGY

Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular high-mobility group box 1 in cellular protection

(2013) Hai Huang et al.   HEPATOLOGY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Human C1 inhibitor attenuates liver ischemia-reperfusion injury and promotes liver regeneration

(2013) Reza F. Saidi et al.   JOURNAL OF SURGICAL RESEARCH

Liver Defatting: An Alternative Approach to Enable Steatotic Liver Transplantation

(2012) N. I. Nativ et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Use of Fatty Liver Grafts in Modern Allocation Systems

(2012) Philipp Dutkowski et al.   ANNALS OF SURGERY

Endoplasmic Reticulum Stress in Nonalcoholic Fatty Liver Disease

(2012) Michael J. Pagliassotti   Annual Review of Nutrition

The role of molecular chaperonins in warm ischemia and reperfusion injury in the steatotic liver: A proteomic study

(2012) Venkataswarup Tiriveedhi et al.   BMC BIOCHEMISTRY

An Examination of Liver Offers to Candidates on the Liver Transplant Wait-List

(2012) Jennifer Cindy Lai et al.   GASTROENTEROLOGY

Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein

(2012) Mario Hebecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins

(2012) Sofie M.A. Walenbergh et al.   JOURNAL OF HEPATOLOGY

Ischemia–reperfusion injury in rat steatotic liver is dependent on NFκB P65 activation

(2012) Sabarinathan Ramachandran et al.   TRANSPLANT IMMUNOLOGY

The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury

(2012) M. Elias-Miró et al.   PPAR Research

The Protective Role of CD59 and Pathogenic Role of Complement in Hepatic Ischemia and Reperfusion Injury

(2011) Jinyan Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Incidence and predictors of post-reperfusion syndrome in living donor liver transplantation

(2011) In S. Chung et al.   CLINICAL TRANSPLANTATION

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

Grade of deceased donor liver macrovesicular steatosis impacts graft and recipient outcomes more than the Donor Risk Index

(2011) Esther L de Graaf et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice

(2011) Michal Aharoni-Simon et al.   LABORATORY INVESTIGATION

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Systemic Complement Activation in Deceased Donors Is Associated With Acute Rejection After Renal Transplantation in the Recipient

(2011) Jeffrey Damman et al.   TRANSPLANTATION

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

(2010) L. Camous et al.   BLOOD

Emerging role of the mannose-binding lectin-dependent pathway of complement activation in clinical organ transplantation

(2010) Stefan P Berger et al.   Current Opinion in Organ Transplantation

The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction

(2010) Claire E. Bamberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Siglec-G Regulates B1 Cell Survival and Selection

(2010) J. Jellusova et al.   JOURNAL OF IMMUNOLOGY

Early diagnosis of primary nonfunction and indication for reoperation after liver transplantation

(2010) Johan Friso Lock et al.   LIVER TRANSPLANTATION

Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts

(2010) Christopher D. Anderson et al.   LIVER TRANSPLANTATION

Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation

(2010) J. Damman et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia–reperfusion

(2010) I Ben Mosbah et al.   Cell Death & Disease

Reactive Oxygen Species Mediate Liver Injury Through Parenchymal Nuclear Factor-κB Inactivation in Prolonged Ischemia/Reperfusion

(2009) Laura Llacuna et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of the complement system in human nonalcoholic fatty liver disease

(2009) Sander S. Rensen et al.   HEPATOLOGY

Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans

(2009) Meng-Yun Chou et al.   JOURNAL OF CLINICAL INVESTIGATION

A Role for Complement in the Enhanced Susceptibility of Steatotic Livers to Ischemia and Reperfusion Injury

(2009) S. He et al.   JOURNAL OF IMMUNOLOGY

Expression of Complement Components Differs Between Kidney Allografts from Living and Deceased Donors

(2009) M. Naesens et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury

(2009) Justin D. Ellett et al.   LIVER TRANSPLANTATION

Quantification of Degree of Steatosis in Extended Criteria Donor Grafts With Standardized Histologic Techniques: Implications for Graft Survival

(2009) F. Frongillo et al.   TRANSPLANTATION PROCEEDINGS

Successful Use of Extended Criteria Donor Grafts With Low to Moderate Steatosis in Patients With Model for End-Stage Liver Disease Scores Below 27

(2009) A.W. Avolio et al.   TRANSPLANTATION PROCEEDINGS

Steatosis Reversibly Increases Hepatocyte Sensitivity to Hypoxia-Reoxygenation Injury

(2008) François Berthiaume et al.   JOURNAL OF SURGICAL RESEARCH

The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury

(2008) Constantino Fondevila et al.   LIVER TRANSPLANTATION

Impact of the donor liver with steatosis in patients with hepatitis C virus: Not so FAst

(2008) Nevin Yilmaz et al.   LIVER TRANSPLANTATION

Consequences of Cold-Ischemia Time on Primary Nonfunction and Patient and Graft Survival in Liver Transplantation: A Meta-Analysis

(2008) James E. Stahl et al.   PLoS One

Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice

(2007) Sabina Paglialunga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM