Journal
PPAR RESEARCH
Volume 2012, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2012/802384
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Funding
- Ministerio de Ciencia e Innovacion Madrid, Spain [BFU2009-07410]
- ACC1O Barcelona, Spain [VALTEC08-2-0033]
- CAPES Foundation, Ministry of Education of Brazilia, Brasilia
- SETH Foundation (Sociedad Espanola de Transplante Hepatico), Spain
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Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. The data suggest that further investigations are required to elucidate whether PPAR could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate PPAR with minor side effects.
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