Glycosylation as a Main Regulator of Growth and Death Factor Receptors Signaling

Inhibition of N-acetylglucosaminyltransferase V enhances the cetuximab-induced radiosensitivity of nasopharyngeal carcinoma cells likely through EGFR N-glycan alterations

(2017) Xiaomin Huang et al.   GLYCOBIOLOGY

Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor

(2017) Henrique Duarte et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression

(2017) Julio de-Freitas-Junior et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GALNT6 expression enhances aggressive phenotypes of ovarian cancer cells by regulating EGFR activity

(2017) Tzu-Chi Lin et al.   Oncotarget

α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells

(2017) Kuo-Chang Wen et al.   Oncotarget

Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype

(2017) Yuh-Jin Liang et al.   Oncotarget

Inhibitor of ppGalNAc-T3-mediated O-glycosylation blocks cancer cell invasiveness and lowers FGF23 levels

(2017) Lina Song et al.   eLife

miR-200b inhibits proliferation and metastasis of breast cancer by targeting fucosyltransferase IV and α1,3-fucosylated glycans

(2017) Q Zheng et al.   Oncogenesis

Metastatic Progression of Prostate Cancer Is Mediated by Autonomous Binding of Galectin-4- O -Glycan to Cancer Cells

(2016) Chin-Hsien Tsai et al.   CANCER RESEARCH

N-glycans of growth factor receptors: their role in receptor function and disease implications

(2016) M. Takahashi et al.   CLINICAL SCIENCE

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Inhibiting post-translational core fucosylation prevents vascular calcification in the model of uremia

(2016) Xinyu Wen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Disease-associated glycans on cell surface proteins

(2016) Motoko Takahashi et al.   MOLECULAR ASPECTS OF MEDICINE

Gestation-associated changes in the glycosylation of placental insulin and insulin-like growth factor receptors

(2016) Dragana Robajac et al.   PLACENTA

Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells

(2016) Chia Chu et al.   PLoS One

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

(2016) Wei-Sheng Chen et al.   Nature Communications

Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation

(2016) Shin-Yun Liu et al.   Oncotarget

Glycosylated Notch and Cancer

(2016) Shanmugasundaram Pakkiriswami et al.   Frontiers in Oncology

Loss of α1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating several cell signaling pathways

(2015) Yuqin Wang et al.   FASEB JOURNAL

Galectin-3 modulates the EGFR signalling-mediated regulation of Sox2 expression via c-Myc in lung cancer

(2015) Hong-Yi Kuo et al.   GLYCOBIOLOGY

NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels

(2015) Alessandra Mozzi et al.   GLYCOBIOLOGY

The role of N-Glycan modification of TNFR1 in inflammatory microglia activation

(2015) Lijian Han et al.   GLYCOCONJUGATE JOURNAL

Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression

(2015) XIU SHAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Lack of glucagon receptor signaling and its implications beyond glucose homeostasis

(2015) M. J. Charron et al.   JOURNAL OF ENDOCRINOLOGY

2-Deoxy-Glucose Downregulates Endothelial AKT and ERK via Interference with N-Linked Glycosylation, Induction of Endoplasmic Reticulum Stress, and GSK3  Activation

(2015) K. Kovacs et al.   MOLECULAR CANCER THERAPEUTICS

Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest

(2015) KIYOYUKI KOBAYASHI et al.   ONCOLOGY REPORTS

Galectin-9 suppresses the proliferation of gastric cancer cells in vitro

(2015) JITSUKO TAKANO et al.   ONCOLOGY REPORTS

Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition

(2015) Hsin-Yung Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new method for detection of tumor driver-dependent changes of protein sialylation in a colon cancer cell line reveals nectin-3 as TGFBR2 target

(2015) Jennifer Lee et al.   PROTEIN SCIENCE

Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression

(2015) Dong Tang et al.   TUMOR BIOLOGY

Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4

(2015) Lili Tian et al.   Oncotarget

Loss of α1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling

(2015) Yuqin Wang et al.   Scientific Reports

GALNT2 suppresses malignant phenotypes through IGF-1 receptor and predicts favorable prognosis in neuroblastoma

(2015) Wan-Ling Ho et al.   Oncotarget

C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2

(2015) Ji-Shiang Hung et al.   Oncotarget

Galectin-1 induces vascular permeability through the neuropilin-1/vascular endothelial growth factor receptor-1 complex

(2014) Ming-Heng Wu et al.   ANGIOGENESIS

Significance of glycosylation in Notch signaling

(2014) Hideyuki Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sialosignaling: Sialyltransferases as engines of self-fueling loops in cancer progression

(2014) Fabio Dall'Olio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Galectin-1 Pulls the Strings on VEGFR2

(2014) Pamela Stanley   CELL

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors

(2014) Diego O. Croci et al.   CELL

N-Glycan Remodeling on Glucagon Receptor Is an Effector of Nutrient Sensing by the Hexosamine Biosynthesis Pathway

(2014) Anita Johswich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Galactoside α2,6-Sialyltranferase 1 Promotes Transforming Growth Factor-β-mediated Epithelial-Mesenchymal Transition

(2014) Jishun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling

(2014) YING LI et al.   Molecular Medicine Reports

GD3 synthase regulates epithelial–mesenchymal transition and metastasis in breast cancer

(2014) T R Sarkar et al.   ONCOGENE

GALNT2 enhances migration and invasion of oral squamous cell carcinoma by regulating EGFR glycosylation and activity

(2014) Mei-Chun Lin et al.   ORAL ONCOLOGY

Mannose Phosphate Isomerase Regulates Fibroblast Growth Factor Receptor Family Signaling and Glioma Radiosensitivity

(2014) Aurélie Cazet et al.   PLoS One

Direct interaction between surface β1,4-galactosyltransferase 1 and epidermal growth factor receptor (EGFR) inhibits EGFR activation in hepatocellular carcinoma

(2013) Wenqing Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fucosylated TGF-β receptors transduces a signal for epithelial–mesenchymal transition in colorectal cancer cells

(2013) M Hirakawa et al.   BRITISH JOURNAL OF CANCER

C1GALT1 Enhances Proliferation of Hepatocellular Carcinoma Cells via Modulating MET Glycosylation and Dimerization

(2013) Y.-M. Wu et al.   CANCER RESEARCH

Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans

(2013) Kazuhiro Sugihara et al.   FEBS LETTERS

N-acetylglucosaminyltransferase V confers hepatoma cells with resistance to anoikis through EGFR/PAK1 activation

(2013) J. Liu et al.   GLYCOBIOLOGY

Analysis of Epithelial Growth Factor-Receptor (EGFR) Phosphorylation in Uterine Smooth Muscle Tumors: Correlation to Mucin-1 and Galectin-3 Expression

(2013) Tobias Weissenbacher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reduction of the ST6 β-Galactosamide α-2,6-Sialyltransferase 1 (ST6GAL1)-catalyzed Sialylation of Nectin-like Molecule 2/Cell Adhesion Molecule 1 and Enhancement of ErbB2/ErbB3 Signaling by MicroRNA-199a

(2013) Akihiro Minami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ganglioside GM3 Depletion Reverses Impaired Wound Healing in Diabetic Mice by Activating IGF-1 and Insulin Receptors

(2013) Xiao-Qi Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

New wrinkles in old receptors: core fucosylation is yet another target to inhibit TGF-β signaling

(2013) Manjeri A. Venkatachalam et al.   KIDNEY INTERNATIONAL

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

Transforming Growth Factor Beta Receptor 2 (TGFBR2) Changes Sialylation in the Microsatellite Unstable (MSI) Colorectal Cancer Cell Line HCT116

(2013) Jennifer Lee et al.   PLoS One

VEGFR1 and VEGFR2 Involvement in Extracellular Galectin-1- and Galectin-3-Induced Angiogenesis

(2013) Nicky D'Haene et al.   PLoS One

Expression of ST3GAL4 Leads to SLex Expression and Induces c-Met Activation and an Invasive Phenotype in Gastric Carcinoma Cells

(2013) Catarina Gomes et al.   PLoS One

N-Linked Glycosylation Supports Cross-Talk between Receptor Tyrosine Kinases and Androgen Receptor

(2013) Harri M. Itkonen et al.   PLoS One

Insulin/IGF-I Signaling Pathways Enhances Tumor Cell Invasion through Bisecting GlcNAc N-glycans Modulation. An Interplay with E-Cadherin

(2013) Julio Cesar Madureira de-Freitas-Junior et al.   PLoS One

TGF-β sensitivity is determined by N-linked glycosylation of the type II TGF-β receptor

(2012) Young-Woong Kim et al.   BIOCHEMICAL JOURNAL

Ganglioside GM3 participates in the TGF-β1-induced epithelial–mesenchymal transition of human lens epithelial cells

(2012) Seok-Jo Kim et al.   BIOCHEMICAL JOURNAL

Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells

(2012) Jung-Jin Park et al.   BIOCHEMICAL PHARMACOLOGY

The ganglioside GD2 induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the GD3 synthase

(2012) Aurélie Cazet et al.   GLYCOBIOLOGY

N-Acetylglucosaminyltransferase V regulates TGF-β response in hepatic stellate cells and the progression of steatohepatitis

(2012) Yoshihiro Kamada et al.   GLYCOBIOLOGY

Sialidase significance for cancer progression

(2012) Taeko Miyagi et al.   GLYCOCONJUGATE JOURNAL

Carbohydrate to carbohydrate interaction in development process and cancer progression

(2012) Kazuko Handa et al.   GLYCOCONJUGATE JOURNAL

Roles ofN-Acetylglucosaminyltransferase III in Epithelial-to-Mesenchymal Transition Induced by Transforming Growth Factor β1 (TGF-β1) in Epithelial Cell Lines

(2012) Qingsong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEU1 Sialidase Expressed in Human Airway Epithelia Regulates Epidermal Growth Factor Receptor (EGFR) and MUC1 Protein Signaling

(2012) Erik P. Lillehoj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Met function requires n-linked glycosylation modification of pro-Met

(2012) Run Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

β-1,4-Galactosyltransferase I involved in Schwann cells proliferation and apoptosis induced by tumor necrosis factor-alpha via the activation of MAP kinases signal pathways

(2012) Qin Yuan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Suppression of FUT1 attenuates cell proliferation in the HER2-overexpressing cancer cell line NCI-N87

(2012) SADAYUKI KAWAI et al.   ONCOLOGY REPORTS

Loss and Recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation Is a Mechanism Involved in Epithelial-Mesenchymal-Epithelial Transitions

(2012) Salomé S. Pinho et al.   PLoS One

Ganglioside GD1a negatively regulates hepatocyte growth factor expression through caveolin-1 at the transcriptional level in murine osteosarcoma cells

(2011) Lan Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mucin Glycosylating Enzyme GALNT2 Regulates the Malignant Character of Hepatocellular Carcinoma by Modifying the EGF Receptor

(2011) Y.-M. Wu et al.   CANCER RESEARCH

Engagement of I-Branching  -1, 6-N-Acetylglucosaminyltransferase 2 in Breast Cancer Metastasis and TGF-  Signaling

(2011) H. Zhang et al.   CANCER RESEARCH

Inhibition of ganglioside GD1a synthesis suppresses the differentiation of human mesenchymal stem cells into osteoblasts

(2011) Hyo Jung Yang et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Mechanisms of cancer-associated glycosylation changes

(2011) Fabio Dall'Olio   Frontiers in Bioscience-Landmark

Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability

(2011) J. Li et al.   GLYCOBIOLOGY

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

Sialylation regulates galectin-3/ligand interplay during mammary tumour progression - a case of targeted uncloaking

(2011) Joana-Tavares de Oliveira et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The Stimulation of IGF-1R Expression by Lewis(y) Antigen Provides a Powerful Development Mechanism of Epithelial Ovarian Carcinoma

(2011) Dawo Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lewis Y regulates signaling molecules of the transforming growth factor β pathway in ovarian carcinoma-derived RMG-I cells

(2011) FEI-FEI LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Galectin-3 Protein Modulates Cell Surface Expression and Activation of Vascular Endothelial Growth Factor Receptor 2 in Human Endothelial Cells

(2011) Anna I. Markowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ST6Gal-I Regulates Macrophage Apoptosis via α2-6 Sialylation of the TNFR1 Death Receptor

(2011) Zhongyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Regulation of Fibroblast Growth Factor 2 (FGF2)-mediated Cell Growth by Polysialic Acid

(2011) Sayaka Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-like growth factor 1 stimulation of androgen receptor activity requires β1A integrins

(2011) Aejaz Sayeed et al.   JOURNAL OF CELLULAR PHYSIOLOGY

β-1,4-Galactosyltransferase I Promotes Tumor Necrosis Factor-α Autocrine via the Activation of MAP Kinase Signal Pathways in Schwann Cells

(2011) Huiguang Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation

(2011) Birger Herzog et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Epidermal Growth Factor Receptor Through Interaction of Ganglioside GM3 with GlcNAc of N-Linked Glycan of the Receptor: Demonstration in ldlD Cells

(2011) Feng Guan et al.   NEUROCHEMICAL RESEARCH

Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells

(2011) J Merlin et al.   ONCOGENE

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

(2011) Y.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An overview of the c-MET signaling pathway

(2011) Shawna Leslie Organ et al.   Therapeutic Advances in Medical Oncology

Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify EGF-dependent ErbB2 phosphorylation

(2010) Simona Milani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Molecular Imaging of N-linked Glycosylation Suggests Glycan Biosynthesis Is a Novel Target for Cancer Therapy

(2010) J. N. Contessa et al.   CLINICAL CANCER RESEARCH

Desialylation of insulin receptors and IGF-1 receptors by neuraminidase-1 controls the net proliferative response of L6 myoblasts to insulin

(2010) M. Arabkhari et al.   GLYCOBIOLOGY

Lewis Y Promotes Growth and Adhesion of Ovarian Carcinoma-Derived RMG-I Cells by Upregulating Growth Factors

(2010) Feifei Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response

(2010) Anna I. Markowska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GD3 Synthase Expression Enhances Proliferation and Tumor Growth of MDA-MB-231 Breast Cancer Cells through c-Met Activation

(2010) A. Cazet et al.   MOLECULAR CANCER RESEARCH

α2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells

(2009) Jin Qian et al.   ACTA PHARMACOLOGICA SINICA

EGF-mediated migration signaling activated by N-acetylglucosaminyltransferase-V via receptor protein tyrosine phosphatase kappa

(2009) Can Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

GD3 synthase overexpression enhances proliferation and migration of MDA-MB-231 breast cancer cells

(2009) Aurélie Cazet et al.   BIOLOGICAL CHEMISTRY

Activation of ER stress and inhibition of EGFR N-glycosylation by tunicamycin enhances susceptibility of human non-small cell lung cancer cells to erlotinib

(2009) Yi-He Ling et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis

(2009) H.-B. Guo et al.   GLYCOBIOLOGY

VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo

(2009) Antonina Kolmakova et al.   GLYCOCONJUGATE JOURNAL

Structure and function of VEGF receptors

(2009) Edward Stuttfeld et al.   IUBMB LIFE

Requirement of Fut8 for the expression of vascular endothelial growth factor receptor-2: a new mechanism for the emphysema-like changes observed in Fut8-deficient mice

(2009) X. Wang et al.   JOURNAL OF BIOCHEMISTRY

Tyrosine Kinase Activity of Epidermal Growth Factor Receptor Is Regulated by GM3 Binding through Carbohydrate to Carbohydrate Interactions

(2009) Nagako Kawashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiton of RET and JAK2 Signals and Upregulation of VEGFR3 Phosphorylation in Vitro by Galectin-1 in Trophoblast Tumor Cells BeWo

(2009) I. Fischer et al.   PLACENTA

Adaptive Regulation at the Cell Surface byN-Glycosylation

(2009) James W. Dennis et al.   TRAFFIC

Effects of gangliosides on the differentiation of human mesenchymal stem cells into osteoblasts by modulating epidermal growth factor receptors

(2008) Sun-Mi Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of N-Linked Glycosylation Disrupts Receptor Tyrosine Kinase Signaling in Tumor Cells

(2008) J. N. Contessa et al.   CANCER RESEARCH

N-Glycan fucosylation of epidermal growth factor receptor modulates receptor activity and sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor

(2008) Kazuko Matsumoto et al.   CANCER SCIENCE

Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: Direct interaction of GM3 with VEGFR-2

(2008) T.-W. Chung et al.   GLYCOBIOLOGY

Ganglioside depletion and EGF responses of human GM3 synthase-deficient fibroblasts

(2008) Yihui Liu et al.   GLYCOBIOLOGY

Thematic Review Series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a

(2008) P. Mukherjee et al.   JOURNAL OF LIPID RESEARCH

Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells

(2008) S H Hsieh et al.   ONCOGENE

Human sialidase as a cancer marker

(2008) Taeko Miyagi et al.   PROTEOMICS

N-glycan of ErbB family plays a crucial role in dimer formation and tumor promotion

(2007) Motoko Takahashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth

(2007) Zhenbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH