Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression

IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

(2017) Heming Li et al.   Molecular Cancer

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway

(2017) Zhi-hua Li et al.   Oncotarget

IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules

(2017) Nikolaos A. Afratis et al.   Scientific Reports

Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway

(2017) A Vasconcelos-dos-Santos et al.   Oncogenesis

TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells

(2017) Katie L. Bailey et al.   PLoS One

Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA/mRNA regulatory network analysis

(2017) Kuo-Hao Ho et al.   Scientific Reports

Lapatinib in Combination With Capecitabine Plus Oxaliplatin in Human Epidermal Growth Factor Receptor 2–Positive Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma: TRIO-013/LOGiC—A Randomized Phase III Trial

(2016) J. Randolph Hecht et al.   JOURNAL OF CLINICAL ONCOLOGY

Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells

(2016) K Tominaga et al.   ONCOGENE

IGF-I Induces Epithelial-to-Mesenchymal Transition via the IGF-IR-Src-MicroRNA-30a-E-Cadherin Pathway in Nasopharyngeal Carcinoma Cells

(2016) Ruoyu Wang et al.   ONCOLOGY RESEARCH

Gestation-associated changes in the glycosylation of placental insulin and insulin-like growth factor receptors

(2016) Dragana Robajac et al.   PLACENTA

IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation

(2016) Gerjon J. Ikink et al.   Nature Communications

O-mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer

(2016) Sandra Carvalho et al.   Oncotarget

Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer

(2016) R J Klement et al.   Oncogenesis

Activation of insulin-like growth factor 1 receptor regulates the radiation-induced lung cancer cell apoptosis

(2015) Heng Zhang et al.   IMMUNOBIOLOGY

Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer

(2015) S Carvalho et al.   ONCOGENE

The role of N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications

(2015) Julio Cesar Madureira de Freitas Junior et al.   Oncotarget

FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

(2015) LaTonia Taliaferro-Smith et al.   Oncotarget

Implication of epithelial-mesenchymal transition in IGF1R-induced resistance to EGFR-TKIs in advanced non-small cell lung cancer

(2015) Juan Zhou et al.   Oncotarget

Insulin-like Growth Factor-Dependent Proliferation and Survival of Triple-Negative Breast Cancer Cells: Implications for Therapy

(2015) Zoë Davison et al.   NEOPLASIA

Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial–mesenchymal transition in non-small cell lung cancer

(2014) Fariz Nurwidya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells

(2014) Ram K. Singh et al.   CANCER LETTERS

Functional Genetic Approach Identifies MET, HER3, IGF1R, INSR Pathways as Determinants of Lapatinib Unresponsiveness in HER2-Positive Gastric Cancer

(2014) Z. Zhang et al.   CLINICAL CANCER RESEARCH

Cancer Metabolism and ElevatedO-GlcNAc in Oncogenic Signaling

(2014) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells

(2014) Heming Li et al.   Molecular Cancer

The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells

(2014) Roberta Malaguarnera et al.   Frontiers in Endocrinology

ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer

(2013) Q Ye et al.   ONCOGENE

Increase of O-Glycosylated Oncofetal Fibronectin in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Epithelial Cells

(2013) Frederico Alisson-Silva et al.   PLoS One

Insulin/IGF-I Signaling Pathways Enhances Tumor Cell Invasion through Bisecting GlcNAc N-glycans Modulation. An Interplay with E-Cadherin

(2013) Julio Cesar Madureira de-Freitas-Junior et al.   PLoS One

IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells

(2013) Satoru Osuka et al.   STEM CELLS

Gastric cancer: adding glycosylation to the equation

(2013) Salomé S. Pinho et al.   TRENDS IN MOLECULAR MEDICINE

E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V

(2012) Salomé S. Pinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Branched N-glycans and their implications for cell adhesion, signaling and clinical applications for cancer biomarkers and in therapeutics

(2012) Naoyuki Taniguchi et al.   BMB Reports

Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence

(2012) J. A. Johnson et al.   DIABETOLOGIA

Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma

(2012) Juanjuan Shan et al.   HEPATOLOGY

N-glycan biosynthesis inhibitors induce in vitro anticancer activity in colorectal cancer cells

(2012) Julio Cesar Madureira de-Freitas-Junior et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Heterodimerization of Glycosylated Insulin-Like Growth Factor-1 Receptors and Insulin Receptors in Cancer Cells Sensitive to Anti-IGF1R Antibody

(2012) Jun Gyu Kim et al.   PLoS One

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

(2012) W. Yi et al.   SCIENCE

Insulin-Like Growth Factor Binding Proteins: A Structural Perspective

(2012) Briony E. Forbes et al.   Frontiers in Endocrinology

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

IGF-1 induces hypoxia-inducible factor 1α-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells

(2011) Jian Yu et al.   BRAIN RESEARCH

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Diabetes and Cancer: Is Diabetes Causally Related to Cancer?

(2011) Sunghwan Suh et al.   Diabetes & Metabolism Journal

Diabetogenic glucose and insulin concentrations modulate transcriptom and protein levels involved in tumour cell migration, adhesion and proliferation

(2010) K Masur et al.   BRITISH JOURNAL OF CANCER

Inhibition of N-linked glycosylation by tunicamycin induces E-cadherin-mediated cell–cell adhesion and inhibits cell proliferation in undifferentiated human colon cancer cells

(2010) Julio Cesar Madureira de Freitas Junior et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Molecular Imaging of N-linked Glycosylation Suggests Glycan Biosynthesis Is a Novel Target for Cancer Therapy

(2010) J. N. Contessa et al.   CLINICAL CANCER RESEARCH

Sialylation of Integrin β1 is Involved in Radiation-Induced Adhesion and Migration in Human Colon Cancer Cells

(2010) Minyoung Lee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Insulin Receptor Isoforms and Insulin-Like Growth Factor Receptor in Human Follicular Cell Precursors from Papillary Thyroid Cancer and Normal Thyroid

(2010) Roberta Malaguarnera et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

O-GlcNAc signaling: a metabolic link between diabetes and cancer?

(2010) C. Slawson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chemoresistant Colorectal Cancer Cells, the Cancer Stem Cell Phenotype, and Increased Sensitivity to Insulin-like Growth Factor-I Receptor Inhibition

(2009) N. A. Dallas et al.   CANCER RESEARCH

The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin

(2009) S. S. Pinho et al.   HUMAN MOLECULAR GENETICS

O-LinkedN-Acetylglucosamine Modification of Insulin Receptor Substrate-1 Occurs in Close Proximity to Multiple SH2 Domain Binding Motifs

(2009) Amanda L. Klein et al.   MOLECULAR & CELLULAR PROTEOMICS

Tumours with PI3K activation are resistant to dietary restriction

(2009) Nada Y. Kalaany et al.   NATURE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Insulin-like Growth Factor-I-Dependent Up-regulation of ZEB1 Drives Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells

(2008) T. R. Graham et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance

(2008) Angelo et al.   Frontiers in Bioscience-Landmark

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

(2008) R. Brooks Robey et al.   SEMINARS IN CANCER BIOLOGY

N-linked glycans of the human insulin receptor and their distribution over the crystal structure

(2007) Lindsay G. Sparrow et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS