Lack of glucagon receptor signaling and its implications beyond glucose homeostasis

Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion

(2014) Woo-Jin Song et al.   Cell Metabolism

Glucagon Is Essential for Adaptive Thermogenesis in Brown Adipose Tissue

(2014) Keita Kinoshita et al.   ENDOCRINOLOGY

Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism

(2014) Holly A. Cyphert et al.   PLoS One

Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes

(2014) R Piran et al.   Cell Death & Disease

Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism

(2013) Ferdinand von Meyenn et al.   Cell Metabolism

Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor-Deficient Mice

(2013) B. A. Omar et al.   DIABETES

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

(2013) K. M. Habegger et al.   DIABETES

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

(2013) F.P.M. O’Harte et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Hypothalamic glucagon signaling inhibits hepatic glucose production

(2013) Patricia I Mighiu et al.   NATURE MEDICINE

Liver-Specific Disruption of the Murine Glucagon Receptor Produces  -Cell Hyperplasia: Evidence for a Circulating  -Cell Growth Factor

(2012) C. Longuet et al.   DIABETES

Regulation of Mouse Intestinal L Cell Progenitors Proliferation by the Glucagon Family of Peptides

(2012) Marine Grigoryan et al.   ENDOCRINOLOGY

Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenance

(2011) Sophia Ouhilal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

(2011) Y. Lee et al.   DIABETES

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

(2011) Fabrizio Thorel et al.   DIABETES

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo

(2010) Eric D. Berglund et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucagon signaling modulates sweet taste responsiveness

(2010) Amanda E.T. Elson et al.   FASEB JOURNAL

The metabolic actions of glucagon revisited

(2010) Kirk M. Habegger et al.   Nature Reviews Endocrinology

Glucagon regulation of energy metabolism

(2010) Kristy M. Heppner et al.   PHYSIOLOGY & BEHAVIOR

Pancreatic β-cell overexpression of the glucagon receptor gene results in enhanced β-cell function and mass

(2009) Richard W. Gelling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Alpha Cells Beget Beta Cells

(2009) Zhengyu Liu et al.   CELL

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Hepatic energy state is regulated by glucagon receptor signaling in mice

(2009) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-Term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control, with Reversible  -Cell Hyperplasia and Hyperglucagonemia

(2009) W. Gu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mice Deficient for Glucagon Gene-Derived Peptides Display Normoglycemia and Hyperplasia of Islet α-Cells But Not of Intestinal L-Cells

(2009) Yoshitaka Hayashi et al.   MOLECULAR ENDOCRINOLOGY

The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

(2008) Christine Longuet et al.   Cell Metabolism

Glucagon increases contractility in ventricle but not in atrium of the rat heart

(2008) Carmen Gonzalez-Muñoz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucagon Receptor Signaling Is Essential for Control of Murine Hepatocyte Survival

(2008) Elaine M. Sinclair et al.   GASTROENTEROLOGY

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

(2008) Ivan Quesada et al.   JOURNAL OF ENDOCRINOLOGY