NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels

Phosphatidic acid-mediated activation and translocation to the cell surface of sialidase NEU3, promoting signaling for cell migration

(2015) Kazuhiro Shiozaki et al.   FASEB JOURNAL

GM3 and cancer

(2015) Sen-Itiroh Hakomori et al.   GLYCOCONJUGATE JOURNAL

Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer

(2013) D J Jonker et al.   BRITISH JOURNAL OF CANCER

Ganglioside GM3 inhibits hepatoma cell motility via down-regulating activity of EGFR and PI3K/AKT signaling pathway

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Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells

(2012) Jung-Jin Park et al.   BIOCHEMICAL PHARMACOLOGY

Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases

(2012) Hidekazu Kuramochi et al.   BMC CANCER

Sialidase significance for cancer progression

(2012) Taeko Miyagi et al.   GLYCOCONJUGATE JOURNAL

The Plasma Membrane Sialidase NEU3 Regulates the Malignancy of Renal Carcinoma Cells by Controlling β1 Integrin Internalization and Recycling

(2012) Cristina Tringali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEU3 Sialidase Is Activated under Hypoxia and Protects Skeletal Muscle Cells from Apoptosis through the Activation of the Epidermal Growth Factor Receptor Signaling Pathway and the Hypoxia-inducible Factor (HIF)-1α

(2012) Raffaella Scaringi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MmNEU3 sialidase over-expression in C2C12 myoblasts delays differentiation and induces hypertrophic myotube formation

(2012) Nadia Papini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibition of ganglioside GD1a synthesis suppresses the differentiation of human mesenchymal stem cells into osteoblasts

(2011) Hyo Jung Yang et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Impact of KRAS, BRAF, PIK3CA Mutations, PTEN, AREG, EREG Expression and Skin Rash in ≥2nd Line Cetuximab-Based Therapy of Colorectal Cancer Patients

(2011) Zacharenia Saridaki et al.   PLoS One

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

(2011) Y.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site-directed mutagenesis

(2010) Amgad Albohy et al.   GLYCOBIOLOGY

Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice

(2009) Kazuhiro Shiozaki et al.   CANCER SCIENCE

Sialic acids as regulators of molecular and cellular interactions

(2009) Roland Schauer   CURRENT OPINION IN STRUCTURAL BIOLOGY

EGFR fluorescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancer

(2009) M Varella-Garcia et al.   JOURNAL OF CLINICAL PATHOLOGY

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Structural insights into sialic acid enzymology

(2008) Alejandro Buschiazzo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Plasma Membrane-associated Sialidase as a Crucial Regulator of Transmembrane Signalling

(2008) T. Miyagi et al.   JOURNAL OF BIOCHEMISTRY

An overview of the epidermal growth factor receptor fluorescence in situ hybridisation challenge in tumour pathology

(2008) V Martin et al.   JOURNAL OF CLINICAL PATHOLOGY

Sialic acids in human health and disease

(2008) Ajit Varki   TRENDS IN MOLECULAR MEDICINE