Transcriptional analysis reveals distinct subtypes in amyotrophic lateral sclerosis: implications for personalized therapy

Eszopiclone Prevents Excitotoxicity and Neurodegeneration in the Hippocampus Induced by Experimental Apnea

(2017) Simon J. Fung et al.   SLEEP

Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex

(2015) Eleonora Aronica et al.   NEUROBIOLOGY OF DISEASE

Neuronal-Specific Overexpression of a Mutant Valosin-Containing Protein Associated with IBMPFD Promotes Aberrant Ubiquitin and TDP-43 Accumulation and Cognitive Dysfunction in Transgenic Mice

(2013) Carlos J. Rodriguez-Ortiz et al.   AMERICAN JOURNAL OF PATHOLOGY

Benzoate, a D-Amino Acid Oxidase Inhibitor, for the Treatment of Early-Phase Alzheimer Disease: A Randomized, Double-Blind, Placebo-Controlled Trial

(2013) Chieh-Hsin Lin et al.   BIOLOGICAL PSYCHIATRY

IGF-1 receptor antagonism inhibits autophagy

(2013) Maurizio Renna et al.   HUMAN MOLECULAR GENETICS

JAK2 inhibition is neuroprotective and reduces astrogliosis after quinolinic acid striatal lesion in adult mice

(2013) Raffaela Silvestre Ignarro et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Different actions of endothelin-1 on chemokine production in rat cultured astrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 and CXCL1/CINC-1

(2013) Yutaka Koyama et al.   Journal of Neuroinflammation

Pre- and postsynaptic mechanisms underlying inhibition of hypoglossal motor neuron excitability by riluzole

(2013) Mark C. Bellingham   JOURNAL OF NEUROPHYSIOLOGY

Calcium Channel Agonists Protect against Neuromuscular Dysfunction in a Genetic Model of TDP-43 Mutation in ALS

(2013) G. A. B. Armstrong et al.   JOURNAL OF NEUROSCIENCE

Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial

(2013) Merit E Cudkowicz et al.   LANCET NEUROLOGY

Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1

(2013) Jinbum Bae et al.   MOLECULES AND CELLS

Effect of chronic treatment with angiotensin type 1 receptor antagonists on striatal dopamine levels in normal rats and in a rat model of Parkinson's disease treated with l-DOPA

(2013) Antonio Dominguez-Meijide et al.   NEUROPHARMACOLOGY

ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions

(2013) M Mizuno et al.   Translational Psychiatry

Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein

(2012) Yukiko Sasazawa et al.   ACS Chemical Biology

Syntheses of Xanthofulvin and Vinaxanthone, Natural Products Enabling Spinal Cord Regeneration

(2012) Abram Axelrod et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Delayed Administration of VEGF Rescues Spinal Motor Neurons from Death with a Short Effective Time Frame in Excitotoxic Experimental Models in Vivo

(2012) Luis B Tovar-y-Romo et al.   ASN Neuro

Angiotensin II AT1receptor blockers as treatments for inflammatory brain disorders

(2012) Juan M. Saavedra   CLINICAL SCIENCE

Involvement of Immune Response in the Pathogenesis of Amyotrophic Lateral Sclerosis: A Therapeutic Opportunity?

(2012) A. Calvo et al.   CNS & Neurological Disorders-Drug Targets

Sigma-1 Receptor Agonists as Therapeutic Drugs for Cognitive Impairment in Neuropsychiatric Diseases

(2012) Tomihisa Niitsu et al.   CURRENT PHARMACEUTICAL DESIGN

Glatiramer Acetate Treatment Increases Stability of Spinal Synapses and Down Regulates MHC I during the Course of EAE

(2012) Juliana M. Scorisa et al.   International Journal of Biological Sciences

Neuroprotective Effects of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), in Ischemic Stroke of Rats

(2012) Ting-Lin Yen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Ataxin-1 and ataxin-2 intermediate-length PolyQ expansions in amyotrophic lateral sclerosis

(2012) F. L. Conforti et al.   NEUROLOGY

Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosis

(2012) P. Gonzalez-Perez et al.   NEUROLOGY

Decreased motor cortex  -aminobutyric acid in amyotrophic lateral sclerosis

(2012) B. R. Foerster et al.   NEUROLOGY

Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model

(2012) C. Sunyach et al.   NEUROPHARMACOLOGY

Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice

(2012) Renzo Mancuso et al.   Neurotherapeutics

Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

(2012) Ernesto Miquel et al.   PLoS One

Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease

(2012) Samuel O. Adeosun et al.   PLoS One

Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically

(2011) Melinda Paizs et al.   Amyotrophic Lateral Sclerosis

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment

(2011) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Regulation of Gene Expression by TDP-43 and FUS/TLS in Frontotemporal Lobar Degeneration

(2011) M. Budini et al.   Current Alzheimer Research

The Role of Immune and Inflammatory Mechanisms in ALS

(2011) P. A. McCombe et al.   CURRENT MOLECULAR MEDICINE

Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis

(2011) Kazunori Tanaka et al.   EXPERIMENTAL NEUROLOGY

Novel thyrotropin-releasing hormone analogs: a patent review

(2011) Kailas S Khomane et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The paradigm of personalized therapy in oncology

(2011) Giampietro Gasparini et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Testing the Therapeutic Potential of Doxycycline in aDrosophila melanogasterModel of Alzheimer Disease

(2011) Rita Costa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

(2011) Maxime Cazorla et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential effect of oxidative or excitotoxic stress on the transcriptional profile of amyotrophic lateral sclerosis-linked mutant SOD1 cultured neurons

(2011) Nadia Boutahar et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse

(2011) Michele Nutini et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel

(2011) Or A. Shemesh et al.   NEUROBIOLOGY OF DISEASE

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Targeting HDACs: A Promising Therapy for Alzheimer's Disease

(2011) Ke Xu et al.   Oxidative Medicine and Cellular Longevity

Simvastatin Prevents Dopaminergic Neurodegeneration in Experimental Parkinsonian Models: The Association with Anti-Inflammatory Responses

(2011) Junqiang Yan et al.   PLoS One

Chlorpromazine Protects Against Apoptosis Induced by Exogenous Stimuli in the Developing Rat Brain

(2011) Jing Wu et al.   PLoS One

D-Amino acid oxidase controls motoneuron degeneration through D-serine

(2011) J. Sasabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in ALS

(2011) Mauro Cozzolino et al.   PROGRESS IN NEUROBIOLOGY

Paraoxonase 2 (PON2) in the mouse central nervous system: A neuroprotective role?

(2011) Gennaro Giordano et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation?

(2010) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice

(2010) Daniel J. Amante et al.   Amyotrophic Lateral Sclerosis

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection

(2010) Junping Xin et al.   BRAIN BEHAVIOR AND IMMUNITY

Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen-glucose depletion

(2010) X Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis

(2010) Claas Janssen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats

(2010) H. Kalonia et al.   NEUROSCIENCE

Cyclotraxin-B, the First Highly Potent and Selective TrkB Inhibitor, Has Anxiolytic Properties in Mice

(2010) Maxime Cazorla et al.   PLoS One

Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase

(2010) J. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Moving toward a predictive and personalized clinical approach in amyotrophic lateral sclerosis: novel developments and future directions in diagnosis, genetics, pathogenesis and therapies

(2010) Beatrice Nefussy et al.   EPMA Journal

Efficacy of thalidomide for the treatment of amyotrophic lateral sclerosis: A phase II open label clinical trial

(2009) Elijah W. Stommel et al.   Amyotrophic Lateral Sclerosis

A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis

(2009) Robert M. Pascuzzi et al.   Amyotrophic Lateral Sclerosis

Rethinking ALS: The FUS about TDP-43

(2009) Clotilde Lagier-Tourenne et al.   CELL

Use of Protein Tyrosine Phosphatase Inhibitors as Promising Targeted Therapeutic Drugs

(2009) P. Heneberg   CURRENT MEDICINAL CHEMISTRY

Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis

(2009) I. Niebroj-Dobosz et al.   EUROPEAN JOURNAL OF NEUROLOGY

Lenalidomide (Revlimid®) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis

(2009) Arie Neymotin et al.   EXPERIMENTAL NEUROLOGY

Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation

(2009) Kana Tsukuda et al.   HYPERTENSION

Differential effects of simvastatin and pravastatin on expression of Alzheimer’s disease-related genes in human astrocytes and neuronal cells

(2009) Weijiang Dong et al.   JOURNAL OF LIPID RESEARCH

Agonist-induced restoration of hippocampal neurogenesis and cognitive improvement in a model of cholinergic denervation

(2009) Jackalina M. Van Kampen et al.   NEUROPHARMACOLOGY

Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

(2009) H. Jarvelainen et al.   PHARMACOLOGICAL REVIEWS

Neural cell cycle dysregulation and central nervous system diseases

(2009) Wei Wang et al.   PROGRESS IN NEUROBIOLOGY

Review: A review of the use of zonisamide in Parkinson’s disease

(2009) Pedro Emilio Bermejo et al.   Therapeutic Advances in Neurological Disorders

Reduced angiotensin II levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

(2008) M. Kawajiri et al.   ACTA NEUROLOGICA SCANDINAVICA

A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS

(2008) Paul H. Gordon et al.   Amyotrophic Lateral Sclerosis

Phase 2 study of sodium phenylbutyrate in ALS

(2008) Merit E. Cudkowicz et al.   Amyotrophic Lateral Sclerosis

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: Therapeutic implications for amyotrophic lateral sclerosis

(2008) William Boston-Howes et al.   EXPERIMENTAL NEUROLOGY

Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model

(2008) H.-L. Feng et al.   NEUROSCIENCE

Regulation of glial inflammatory mediators synthesis: Possible role of endothelins

(2008) Talia Filipovich et al.   PEPTIDES

In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties

(2007) Tiziana Adage et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY