Targeting HDACs: A Promising Therapy for Alzheimer's Disease

Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

(2017) Yitshak I. Francis et al.   JOURNAL OF ALZHEIMERS DISEASE

A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase

(2011) David M. Taylor et al.   ACS Chemical Biology

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

(2011) S. C. McQuown et al.   JOURNAL OF NEUROSCIENCE

Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3 

(2011) F. H. Bardai et al.   JOURNAL OF NEUROSCIENCE

The role of histone acetylation in age-associated memory impairment and Alzheimer’s disease

(2011) Roman Manuel Stilling et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture

(2011) Sun Hee Kim et al.   PLoS One

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest

(2010) Yumiko Kawamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons

(2010) Zhaoxu Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Manipulating the brain with epigenetics

(2010) Edward Korzus   NATURE NEUROSCIENCE

Stress and the epigenetic landscape: a link to the pathobiology of human diseases?

(2010) Sarah E. Johnstone et al.   NATURE REVIEWS GENETICS

HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons

(2010) Sigeng Chen et al.   PLoS One

Histone Deacetylase 6 (HDAC6) Is an Independent Deacetylase for α-Tubulin

(2010) Zhiqiang Zhao et al.   PROTEIN AND PEPTIDE LETTERS

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Histone Deacetylases 1 and 2 Form a Developmental Switch That Controls Excitatory Synapse Maturation and Function

(2009) M. W. Akhtar et al.   JOURNAL OF NEUROSCIENCE

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

HDAC6 is a target for protection and regeneration following injury in the nervous system

(2009) M. A. Rivieccio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE