Angiotensin II AT1receptor blockers as treatments for inflammatory brain disorders

Alzheimer's Disease and Peripheral Infections: The Possible Contribution from Periodontal Infections, Model and Hypothesis

(2017) Angela R. Kamer et al.   JOURNAL OF ALZHEIMERS DISEASE

Antihypertensive Treatments, Cognitive Decline, and Dementia

(2017) Emmanuelle Duron et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammatory Risk Factors and Pathologies Associated with Alzheimers Disease

(2012) M. Sastre et al.   Current Alzheimer Research

Update on Cardiovascular Safety of PPARgamma Agonists and Relevance to Medicinal Chemistry and Clinical Pharmacology

(2012) Andreea Ciudin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Renin-Angiotensin-Aldosterone System: The Forgotten Stress Hormone System: Relationship to Depression and Sleep

(2012) H. Murck et al.   PHARMACOPSYCHIATRY

Angiotensin II AT1 Receptor Blockers Ameliorate Inflammatory Stress: A Beneficial Effect for the Treatment of Brain Disorders

(2011) Juan M. Saavedra   CELLULAR AND MOLECULAR NEUROBIOLOGY

Lower Frequency of Antidepressant Use in Patients on Renin-Angiotensin-Aldosterone System Modifying Medications

(2011) Suhayl J. Nasr et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeting metabolic inflammation in Parkinson’s disease: Implications for prospective therapeutic strategies

(2011) Ming Lu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Pharmacotherapy and Prevention of Vascular Dementia

(2011) A. Moretti et al.   CNS & Neurological Disorders-Drug Targets

Delayed inhibition of angiotensin II receptor type 1 reduces secondary brain damage and improves functional recovery after experimental brain trauma*

(2011) Ralph Timaru-Kast et al.   CRITICAL CARE MEDICINE

The central nervous system and inflammation in hypertension

(2011) Paul J Marvar et al.   CURRENT OPINION IN PHARMACOLOGY

Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases

(2011) Paula Grammas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Angiotensin II and aldosterone-induced neuronal damage in neurons through an astrocyte-dependent mechanism

(2011) Li-Juan Min et al.   HYPERTENSION RESEARCH

Subchronic treatment with aldosterone induces depression-like behaviours and gene expression changes relevant to major depressive disorder

(2011) Natasa Hlavacova et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cerebral Microvascular Inflammation in DOCA Salt-Induced Hypertension: Role of Angiotensin II and Mitochondrial Superoxide

(2011) Stephen F Rodrigues et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

PROGRESS: Prevention of Recurrent Stroke

(2011) Hisatomi Arima et al.   Journal of Clinical Hypertension

Angiotensin-Converting Enzyme Inhibitors

(2011) Joseph L. Izzo Jr et al.   Journal of Clinical Hypertension

Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes

(2011) Tao Pang et al.   JOURNAL OF HYPERTENSION

Regulation of angiotensinogen by angiotensin II in mouse primary astrocyte cultures

(2011) E. L. O’Callaghan et al.   JOURNAL OF NEUROCHEMISTRY

Endothelial and inflammatory markers in relation to progression of ischaemic cerebral small-vessel disease and cognitive impairment: a 6-year longitudinal study in patients with type 2 diabetes mellitus

(2011) T. Umemura et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

A role for central nervous system PPAR-γ in the regulation of energy balance

(2011) Karen K Ryan et al.   NATURE MEDICINE

Neuroprotective mechanisms of peroxisome proliferator-activated receptor agonists in Alzheimer’s disease

(2011) Rupinder K. Sodhi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Neuroanatomical evidence demonstrating the existence of the vagal anti-inflammatory reflex in the intestine

(2011) C. Cailotto et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Experimental depression induces renal oxidative stress in rats

(2011) Adriana Pedreañez et al.   PHYSIOLOGY & BEHAVIOR

Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats

(2011) Donglin Zhu et al.   PLoS One

Age-associated chronic diseases require age-old medicine: Role of chronic inflammation

(2011) Sahdeo Prasad et al.   PREVENTIVE MEDICINE

The role of the brain renin–angiotensin system in hypertension: Implications for new treatment

(2011) Yannick Marc et al.   PROGRESS IN NEUROBIOLOGY

Mineralocorticoid receptors in the brain and cardiovascular regulation: minority rule?

(2011) Elise P. Gomez-Sanchez   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good

(2010) Ping Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Linking Molecules to Mood: New Insight Into the Biology of Depression

(2010) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy

(2010) Michael Bader   Annual Review of Pharmacology and Toxicology

A Randomized Pilot Clinical Trial of the Safety of Pioglitazone in Treatment of Patients With Alzheimer Disease

(2010) David S. Geldmacher et al.   ARCHIVES OF NEUROLOGY

Nutrient Modification of the Innate Immune Response

(2010) Eric A. Schwartz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Characterization of new PPARγ agonists: Benzimidazole derivatives—importance of positions 5 and 6, and computational studies on the binding mode

(2010) Matthias Goebel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acute management of acquired brain injury part II: An evidence-based review of pharmacological interventions

(2010) Matthew J. Meyer et al.   BRAIN INJURY

Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia

(2010) Yukiko Kasahara et al.   BRAIN RESEARCH

Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen-glucose depletion

(2010) X Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Pleiotropic Effects of Inhibitors of the RAAS in the Diabetic Population: Above and Beyond Blood Pressure Lowering

(2010) Haisam Ismail et al.   Current Diabetes Reports

Depression gets old fast: do stress and depression accelerate cell aging?

(2010) Owen M. Wolkowitz et al.   DEPRESSION AND ANXIETY

The angiotensin AT2 receptor in inflammation

(2010) F. Rompe et al.   DRUG NEWS & PERSPECTIVES

Angiotensin type 1 receptor antagonist inhibits lipopolysaccharide-induced stimulation of rat microglial cells by suppressing nuclear factor κB and activator protein-1 activation

(2010) Michio Miyoshi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Translational promise of the apelin-APJ system

(2010) G. Barnes et al.   HEART

Losartan inhibits LPS-induced inflammatory signaling through a PPARγ-dependent mechanism in human THP-1 macrophages

(2010) Jianbo An et al.   HYPERTENSION RESEARCH

The Angiotensin II Type 1 Receptor Antagonist Olmesartan Preserves Cerebral Blood Flow and Cerebrovascular Reserve Capacity, and Accelerates Rehabilitative Outcomes in Hypertensive Patients with a History of Stroke

(2010) Shuji Matsumoto et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

(2010) Teuntje M. J. C. Andriessen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Angiotensin II sustains brain inflammation in mice via TGF-β

(2010) Tobias V. Lanz et al.   JOURNAL OF CLINICAL INVESTIGATION

More indirect evidence of potential neuroprotective benefits of angiotensin receptor blockers

(2010) Craig Anderson   JOURNAL OF HYPERTENSION

Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-γ activation in diabetic mice

(2010) Jun Iwanami et al.   JOURNAL OF HYPERTENSION

Design, Synthesis, and Docking Studies of Novel Benzimidazoles for the Treatment of Metabolic Syndrome

(2010) Cassia S. Mizuno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies

(2010) Craig Anderson et al.   LANCET NEUROLOGY

A Generalist's Guide to Treating Patients With Depression With an Emphasis on Using Side Effects to Tailor Antidepressant Therapy

(2010) J. Michael Bostwick   MAYO CLINIC PROCEEDINGS

Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation

(2010) Julius Benicky et al.   NEUROPSYCHOPHARMACOLOGY

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors

(2010) M. Berk et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Clinical trials in traumatic brain injury: Past experience and current developments

(2010) Andrew I. R. Maas et al.   Neurotherapeutics

PPAR Modulation of Kinase-Linked Receptor Signaling in Physiology and Disease

(2010) Nicolas Rotman et al.   PHYSIOLOGY

Nuclear factor- B is a critical mediator of stress-impaired neurogenesis and depressive behavior

(2010) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications

(2010) Juan M. Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus

(2010) Kenneth A Jenrow et al.   Radiation Oncology

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Guidelines for the Primary Prevention of Stroke

(2010) Larry B. Goldstein et al.   STROKE

Effect of cilnidipine vs losartan on cerebral blood flow in hypertensive patients with a history of ischemic stroke: a randomized controlled trial

(2009) K.-S. Hong et al.   ACTA NEUROLOGICA SCANDINAVICA

Alzheimer's disease and infection: Do infectious agents contribute to progression of Alzheimer's disease?

(2009) Kie Honjo et al.   Alzheimers & Dementia

Association of Depressive Symptoms With All-Cause and Ischemic Heart Disease Mortality in Adults With Self-Reported Hypertension

(2009) R. N. Axon et al.   AMERICAN JOURNAL OF HYPERTENSION

Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen

(2009) Enrique Sánchez-Lemus et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The relationships among heart rate variability, inflammatory markers and depression in coronary heart disease patients

(2009) Nancy Frasure-Smith et al.   BRAIN BEHAVIOR AND IMMUNITY

In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland

(2009) Enrique Sánchez-Lemus et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation

(2009) A. Denes et al.   BRAIN BEHAVIOR AND IMMUNITY

Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery

(2009) Julius Benicky et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Crosstalk between peroxisome proliferator-activated receptor-γ and angiotensin II in renal tubular epithelial cells in IgA nephropathy

(2009) Jing Xiao et al.   CLINICAL IMMUNOLOGY

PPARγ and its ligands: therapeutic implications in cardiovascular disease

(2009) Luis Villacorta et al.   CLINICAL SCIENCE

Role of Infection in the Pathogenesis of Alzheimerʼs Disease

(2009) Clive Holmes et al.   CNS DRUGS

The potential role of the angiotensin subtype 2 receptor in cardiovascular protection

(2009) Helmy M. Siragy   CURRENT HYPERTENSION REPORTS

PPARs: the vasculature, inflammation and hypertension

(2009) Sheng Zhong Duan et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Mineralocorticoid receptors, inflammation and sympathetic drive in a rat model of systolic heart failure

(2009) Robert B. Felder   EXPERIMENTAL PHYSIOLOGY

Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors

(2009) Albert Fournier et al.   Expert Review of Neurotherapeutics

The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor

(2009) Enzo et al.   Frontiers in Bioscience-Landmark

Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation

(2009) Kana Tsukuda et al.   HYPERTENSION

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Angiotensin II Modulates BBB Permeability via Activation of the AT1 Receptor in Brain Endothelial Cells

(2009) Melissa A Fleegal-DeMotta et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Disruption of the Ang II type 1 receptor promotes longevity in mice

(2009) Ariela Benigni et al.   JOURNAL OF CLINICAL INVESTIGATION

The inflammatory response in the MPTP model of Parkinson’s disease is mediated by brain angiotensin: relevance to progression of the disease

(2009) Belen Joglar et al.   JOURNAL OF NEUROCHEMISTRY

Involvement of the AT1receptor subtype in the effects of angiotensin IV and LVV-haemorphin 7 on hippocampal neurotransmitter levels and spatial working memory

(2009) Dimitri De Bundel et al.   JOURNAL OF NEUROCHEMISTRY

Small but powerful: Short peptide hormones and their role in autoimmune inflammation

(2009) F. Lühder et al.   JOURNAL OF NEUROIMMUNOLOGY

Modulation of the mineralocorticoid receptor as add-on treatment in depression: A randomized, double-blind, placebo-controlled proof-of-concept study

(2009) Christian Otte et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Eplerenone, a selective mineralocorticoid receptor blocker, exerts anxiolytic effects accompanied by changes in stress hormone release

(2009) Natasa Hlavacova et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Supramaximal Dose of Candesartan in Proteinuric Renal Disease

(2009) E. Burgess et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

PPARγ agonist, rosiglitazone, regulates angiotensin II-induced vascular inflammation through the TLR4-dependent signaling pathway

(2009) Yuanyuan Ji et al.   LABORATORY INVESTIGATION

Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial

(2009) Marvin A Konstam et al.   LANCET

New aspects of rapid aldosterone signaling

(2009) C. Grossmann et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Gaining entry to an uninflamed brain

(2009) Robert C Axtell et al.   NATURE IMMUNOLOGY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Seven decades of angiotensin (1939–2009)

(2009) Ranko Skrbic et al.   PEPTIDES

A current view of brain renin–angiotensin system: Is the (pro)renin receptor the missing link?

(2009) Adolfo E. Cuadra et al.   PHARMACOLOGY & THERAPEUTICS

Catecholaminergic Systems in Stress: Structural and Molecular Genetic Approaches

(2009) Richard Kvetnansky et al.   PHYSIOLOGICAL REVIEWS

Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system

(2009) J. Stegbauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity

(2009) M. Platten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress, depression and cardiovascular dysregulation: A review of neurobiological mechanisms and the integration of research from preclinical disease models

(2009) Angela J. Grippo et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Angiotensins in Alzheimer's disease – friend or foe?

(2009) Patrick G. Kehoe et al.   TRENDS IN NEUROSCIENCES

Candesartan improves memory decline in mice: Involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin

(2008) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Angiotensin II AT1Receptor Blockade Decreases Lipopolysaccharide-Induced Inflammation in the Rat Adrenal Gland

(2008) Enrique Sanchez-Lemus et al.   ENDOCRINOLOGY

Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators

(2008) Bruce S. McEwen   EUROPEAN JOURNAL OF PHARMACOLOGY

The controversial effects of thiazolidinediones on cardiovascular morbidity and mortality

(2008) Panagiotis C. Stafylas et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The AT1 Receptor Antagonist, L-158,809, Prevents or Ameliorates Fractionated Whole-Brain Irradiation–Induced Cognitive Impairment

(2008) Mike E. Robbins et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Brain renin angiotensin in disease

(2008) M. Ian Phillips et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials

(2008) Nish Chaturvedi et al.   LANCET

Sartan–AT1 receptor interactions: In vitro evidence for insurmountable antagonism and inverse agonism

(2008) I. Van Liefde et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neuroinflammation Associated with Aging Sensitizes the Brain to the Effects of Infection or Stress

(2008) Nathan L. Sparkman et al.   NEUROIMMUNOMODULATION

Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells

(2008) J.J. Li et al.   NEUROSCIENCE

Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: Comorbidity between depression and neurodegenerative disorders

(2008) H ANISMAN et al.   PROGRESS IN NEUROBIOLOGY

Angiotensin II AT1receptor blockade selectively enhances brain AT2receptor expression, and abolishes the cold-restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneously hypertensive rats

(2008) C. Bregonzio et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic–pituitary–adrenal (HPA) axis and improves the affect of patients with diabetes mellitus type 2: Preliminary results

(2008) Maria G. Pavlatou et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

The HPA axis in major depression: classical theories and new developments

(2008) Carmine M. Pariante et al.   TRENDS IN NEUROSCIENCES

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

(2007) Maryse Letiembre et al.   NEUROBIOLOGY OF AGING

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING

Brain Angiotensin II Modulates Sympathoadrenal and Hypothalamic Pituitary Adrenocortical Activation during Stress

(2003) Daniela Jezova et al.   JOURNAL OF NEUROENDOCRINOLOGY