A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

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AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

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The dynamic organization of fungal acetyl-CoA carboxylase

(2016) Moritz Hunkeler et al.   Nature Communications

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism

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Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer

(2015) Jia Wei et al.   NATURE

Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase

(2015) Ashley R. Jurado et al.   Nature Communications

Improving polyketide and fatty acid synthesis by engineering of the yeast acetyl-CoA carboxylase

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Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase

(2014) Timothy H. Tran et al.   NATURE

Structure and function of biotin-dependent carboxylases

(2012) Liang Tong   CELLULAR AND MOLECULAR LIFE SCIENCES

Crystal Structure of Urea Carboxylase Provides Insights into the Carboxyltransfer Reaction

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The enzymes of biotin dependent CO2metabolism: What structures reveal about their reaction mechanisms

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Iterative Stable Alignment and Clustering of 2D Transmission Electron Microscope Images

(2012) Zhengfan Yang et al.   STRUCTURE

Structure, function and selective inhibition of bacterial acetyl-coa carboxylase

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The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

An unanticipated architecture of the 750-kDa α6β6 holoenzyme of 3-methylcrotonyl-CoA carboxylase

(2011) Christine S. Huang et al.   NATURE

Crystal structure of the α6β6 holoenzyme of propionyl-coenzyme A carboxylase

(2010) Christine S. Huang et al.   NATURE

Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK

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Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

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Fatty acid metabolism: target for metabolic syndrome

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Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction

(2008) Song Xiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SNF1/AMPK pathways in yeast

(2007) Kristina Hedbacker   Frontiers in Bioscience-Landmark