The structure of the apo cAMP-binding domain of HCN4 - a stepping stone toward understanding the cAMP-dependent modulation of the hyperpolarization-activated cyclic-nucleotide-gated ion channels

Role of Dimers in the cAMP-Dependent Activation of Hyperpolarization-Activated Cyclic-Nucleotide-Modulated (HCN) Ion Channels

(2018) Bryan VanSchouwen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia

(2017) Stephen Boulton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of cGMP-dependent protein kinase Iβ cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation

(2016) James C. Campbell et al.   FEBS LETTERS

Structural Basis of Tonic Inhibition by Dimers of Dimers in Hyperpolarization-Activated Cyclic-Nucleotide-Modulated (HCN) Ion Channels

(2016) Bryan VanSchouwen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Distinct Signaling Roles of cIMP, cCMP, and cUMP

(2016) Roland Seifert   STRUCTURE

Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening

(2016) Leo C.T. Ng et al.   STRUCTURE

Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?

(2016) Gareth R. Tibbs et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors

(2015) Geoffrey C. Li et al.   BIOCHEMISTRY

Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels

(2015) Bryan VanSchouwen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)

(2015) Bryan VanSchouwen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of State-Specific Association Constants in Allosteric Sensors through Molecular Stapling and NMR

(2015) Kody J. Moleschi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric linkers in cAMP signalling

(2014) Madoka Akimoto et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP

(2014) Madoka Akimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using Markov State Models to Develop a Mechanistic Understanding of Protein Kinase A Regulatory Subunit RIα Activation in Response to cAMP Binding

(2014) Britton W. Boras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synchronous Opening and Closing Motions Are Essential for cAMP-Dependent Protein Kinase A Signaling

(2014) Atul K. Srivastava et al.   STRUCTURE

HCN channels: Function and clinical implications

(2013) E. E. Benarroch   NEUROLOGY

Signaling through dynamic linkers as revealed by PKA

(2013) M. Akimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I

(2013) Gilbert Y. Huang et al.   STRUCTURE

cAMP-dependent allostery and dynamics in Epac: an NMR view

(2012) Rajeevan Selvaratnam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Projection Analysis of NMR Chemical Shifts Reveals Extended EPAC Autoinhibition Determinants

(2012) Rajeevan Selvaratnam et al.   BIOPHYSICAL JOURNAL

Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP

(2012) Xiangang Zong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR

(2012) Rajeevan Selvaratnam et al.   PLoS One

Role of Dynamics in the Autoinhibition and Activation of the Exchange Protein Directly Activated by Cyclic AMP (EPAC)

(2011) Bryan VanSchouwen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetramerization Dynamics of C-terminal Domain Underlies Isoform-specific cAMP Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels

(2011) Marco Lolicato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels

(2011) Jana Kusch et al.   Nature Chemical Biology

Mapping allostery through the covariance analysis of NMR chemical shifts

(2011) R. Selvaratnam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate Control

(2010) Patrick A. Schweizer et al.   Circulation-Arrhythmia and Electrophysiology

Communication between Tandem cAMP Binding Domains in the Regulatory Subunit of Protein Kinase A-Iα as Revealed by Domain-silencing Mutations

(2010) E. Tyler McNicholl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

(2010) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction of Epac1 and Ran Promotes Rap1 Activation at the Nuclear Envelope

(2010) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating

(2010) N. L. Wicks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains

(2009) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function

(2009) Manabu Niimura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mapping the structure and conformational movements of proteins with transition metal ion FRET

(2009) Justin W Taraska et al.   NATURE METHODS

Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP

(2008) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY