Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)

Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels

(2015) Bryan VanSchouwen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation

(2015) Jonggul Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR

(2014) Stephen Boulton et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Isomerase-Catalyzed Binding of Interleukin-1 Receptor-Associated Kinase 1 to the EVH1 Domain of Vasodilator-Stimulated Phosphoprotein

(2014) Alexander I. Greenwood et al.   BIOCHEMISTRY

Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design

(2014) Gilbert Y. Huang et al.   BIOCHEMISTRY

A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP

(2014) Madoka Akimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Roles of the RIIβ Linker and N-terminal Cyclic Nucleotide-binding Domain in Determining the Unique Structures of the Type IIβ Protein Kinase A

(2014) Donald K. Blumenthal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles of Allosteric Interactions in Cell Signaling

(2014) Ruth Nussinov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synchronous Opening and Closing Motions Are Essential for cAMP-Dependent Protein Kinase A Signaling

(2014) Atul K. Srivastava et al.   STRUCTURE

Unraveling structural mechanisms of allosteric drug action

(2014) Ruth Nussinov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis

(2014) Stephen Boulton et al.   Scientific Reports

Multiple conformational selection and induced fit events take place in allosteric propagation

(2013) Ruth Nussinov et al.   BIOPHYSICAL CHEMISTRY

Signaling through dynamic linkers as revealed by PKA

(2013) M. Akimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I

(2013) Gilbert Y. Huang et al.   STRUCTURE

Complete Thermodynamic and Kinetic Characterization of the Isomer-Specific Interaction between Pin1-WW Domain and the Amyloid Precursor Protein Cytoplasmic Tail Phosphorylated at Thr668

(2012) Soumya De et al.   BIOCHEMISTRY

The Projection Analysis of NMR Chemical Shifts Reveals Extended EPAC Autoinhibition Determinants

(2012) Rajeevan Selvaratnam et al.   BIOPHYSICAL JOURNAL

The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR

(2012) Rajeevan Selvaratnam et al.   PLoS One

Differential activation of cAMP- and cGMP-dependent protein kinases by cyclic purine and pyrimidine nucleotides

(2011) Sabine Wolter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Dynamics in the Autoinhibition and Activation of the Exchange Protein Directly Activated by Cyclic AMP (EPAC)

(2011) Bryan VanSchouwen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cAMP-Dependent Protein Kinase A Selects the Excited State of the Membrane Substrate Phospholamban

(2011) Larry R. Masterson et al.   JOURNAL OF MOLECULAR BIOLOGY

FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells

(2011) Sebastian Börner et al.   Nature Protocols

Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding

(2011) Jeong Joo Kim et al.   PLoS One

Mapping allostery through the covariance analysis of NMR chemical shifts

(2011) R. Selvaratnam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication

(2011) Brent W. Osborne et al.   STRUCTURE

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

Sensing Domain Dynamics in Protein Kinase A-Iα Complexes by Solution X-ray Scattering

(2009) Cecilia Y. Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains

(2009) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Probabilistic Interaction Network of Evidence Algorithm and its Application to Complete Labeling of Peak Lists from Protein NMR Spectroscopy

(2009) Arash Bahrami et al.   PLoS Computational Biology

Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP

(2008) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

(2008) Holger Rehmann et al.   NATURE

cGMP-binding Prepares PKG for Substrate Binding by Disclosing the C-terminal Domain

(2007) Vera Alverdi et al.   JOURNAL OF MOLECULAR BIOLOGY