Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia

NMR structure and conformational dynamics of AtPDFL2.1, a defensin-like peptide from Arabidopsis thaliana

(2016) Reza Omidvar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Protein Allostery and Conformational Dynamics

(2016) Jingjing Guo et al.   CHEMICAL REVIEWS

Introduction to Protein Ensembles and Allostery

(2016) Ruth Nussinov   CHEMICAL REVIEWS

Advances in NMR Methods To Map Allosteric Sites: From Models to Translation

(2016) Stephen Boulton et al.   CHEMICAL REVIEWS

Structural Basis of Tonic Inhibition by Dimers of Dimers in Hyperpolarization-Activated Cyclic-Nucleotide-Modulated (HCN) Ion Channels

(2016) Bryan VanSchouwen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Conformational footprints

(2016) Buyong Ma et al.   Nature Chemical Biology

Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A

(2016) Cong Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy

(2016) Ashok Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Signaling Roles of cIMP, cCMP, and cUMP

(2016) Roland Seifert   STRUCTURE

Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening

(2016) Leo C.T. Ng et al.   STRUCTURE

A Dynamic molecular basis for malfunction in disease mutants of p97/VCP

(2016) Anne K Schuetz et al.   eLife

Dynamically Driven Protein Allostery Exhibits Disparate Responses for Fast and Slow Motions

(2015) Jingjing Guo et al.   BIOPHYSICAL JOURNAL

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia

(2015) Mirko Baruscotti et al.   EUROPEAN HEART JOURNAL

Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels

(2015) Bryan VanSchouwen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)

(2015) Bryan VanSchouwen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation

(2015) Jonggul Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR

(2014) Stephen Boulton et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current

(2014) Arie O. Verkerk et al.   EUROPACE

A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP

(2014) Madoka Akimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding

(2014) Alessandro Cembran et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis

(2014) Stephen Boulton et al.   Scientific Reports

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

Funny channel gene mutations associated with arrhythmias

(2013) Dario DiFrancesco   JOURNAL OF PHYSIOLOGY-LONDON

HCN channels: Function and clinical implications

(2013) E. E. Benarroch   NEUROLOGY

Signaling through dynamic linkers as revealed by PKA

(2013) M. Akimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Projection Analysis of NMR Chemical Shifts Reveals Extended EPAC Autoinhibition Determinants

(2012) Rajeevan Selvaratnam et al.   BIOPHYSICAL JOURNAL

The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR

(2012) Rajeevan Selvaratnam et al.   PLoS One

Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel

(2012) Xinping Xu et al.   STRUCTURE

Tetramerization Dynamics of C-terminal Domain Underlies Isoform-specific cAMP Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels

(2011) Marco Lolicato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete determination of the Pin1 catalytic domain thermodynamic cycle by NMR lineshape analysis

(2011) Alexander I. Greenwood et al.   JOURNAL OF BIOMOLECULAR NMR

Mapping allostery through the covariance analysis of NMR chemical shifts

(2011) R. Selvaratnam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An introduction to NMR-based approaches for measuring protein dynamics

(2010) Ian R. Kleckner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate Control

(2010) Patrick A. Schweizer et al.   Circulation-Arrhythmia and Electrophysiology

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

(2010) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating

(2010) N. L. Wicks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains

(2009) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Mapping the structure and conformational movements of proteins with transition metal ion FRET

(2009) Justin W Taraska et al.   NATURE METHODS

Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP

(2008) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY