Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet–induced systemic inflammation, microglial activation, and reduced neuroplasticity

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

(2017) Maria Ines Pinto-Sanchez et al.   GASTROENTEROLOGY

The Gut Microbiota and Alzheimer’s Disease

(2017) Chunmei Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

(2017) Preeti Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti-Inflammatory Effects in Microglial Cells

(2017) Natalia Yanguas-Casás et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation

(2017) Lili Sheng et al.   JOURNAL OF PATHOLOGY

Bariatric surgery may reduce the risk of Alzheimer’s diseases through GLP-1 mediated neuroprotective effects

(2017) Hari B. Keshava et al.   MEDICAL HYPOTHESES

FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

(2017) Qingzhi Wang et al.   MOLECULAR NEUROBIOLOGY

Structure–Property Relationships in Sodium Muricholate Derivative (Bile Salts) Micellization: The Effect of Conformation of Steroid Skeleton on Hydrophobicity and Micelle Formation–Pattern Recognition and Potential Membranoprotective Properties

(2017) Mihalj Poša et al.   MOLECULAR PHARMACEUTICS

Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord

(2017) Irena Lavrnja et al.   Scientific Reports

Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain

(2017) Kendra L. Puig et al.   Scientific Reports

Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis

(2017) Sophie Ayciriex et al.   Frontiers in Molecular Neuroscience

Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation

(2017) Lili Sheng et al.   Scientific Reports

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

(2017) Laura Bonfili et al.   Scientific Reports

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

(2017) Kelly A. Fader et al.   Scientific Reports

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC

(2016) Ronald Schilderink et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of a ketogenic diet on adipose tissue, liver, and serum biomarkers in sedentary rats and rats that exercised via resisted voluntary wheel running

(2016) Angelia Maleah Holland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Differential Kv1.3, KCa3.1, and Kir2.1 expression in “classically” and “alternatively” activated microglia

(2016) Hai M. Nguyen et al.   GLIA

FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats

(2016) Piangkwan Sa-nguanmoo et al.   HORMONES AND BEHAVIOR

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis

(2016) Guoxiang Xie et al.   INTERNATIONAL JOURNAL OF CANCER

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

(2016) Francesca Pistollato et al.   NUTRITION REVIEWS

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

TGR5 signaling reduces neuroinflammation during hepatic encephalopathy

(2015) Matthew McMillin et al.   JOURNAL OF NEUROCHEMISTRY

Dysregulation of Glutamine Transporter SNAT1 in Rett Syndrome Microglia: A Mechanism for Mitochondrial Dysfunction and Neurotoxicity

(2015) L.-W. Jin et al.   JOURNAL OF NEUROSCIENCE

Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance

(2015) Mohamed Sham Shihabudeen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Proteobacteria: microbial signature of dysbiosis in gut microbiota

(2015) Na-Ri Shin et al.   TRENDS IN BIOTECHNOLOGY

Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior

(2015) Fei Huang et al.   Frontiers in Behavioral Neuroscience

Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding

(2014) Yuqi He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

All-trans retinoic acid regulates hepatic bile acid homeostasis

(2014) Fan Yang et al.   BIOCHEMICAL PHARMACOLOGY

Longitudinal Inflammation, Cognitive Decline, and Alzheimer’s Disease: A Mini-Review

(2014) B M Bettcher et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

(2014) Anusha Jayaraman et al.   Current Diabetes Reports

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer

(2014) Jessica Tsuei et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Retinoic acid regulates several genes in bile acid and lipid metabolism via upregulation of small heterodimer partner in hepatocytes

(2014) Abulkhair Mamoon et al.   GENE

Nutrient patterns and brain biomarkers of Alzheimer’s disease in cognitively normal individuals

(2014) V. Berti et al.   Journal of Nutrition Health & Aging

Correlation between the human fecal microbiota and depression

(2014) A. Naseribafrouei et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes

(2014) Le Zhan et al.   PLoS One

Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S

(2014) Vanitha Bala et al.   Frontiers in Physiology

IL-17A Synergistically Enhances Bile Acid–Induced Inflammation during Obstructive Cholestasis

(2013) Kate M. O'Brien et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profiling

(2013) Yuqi He et al.   BMC GENOMICS

Ion Channels as Drug Targets in Central Nervous System Disorders

(2013) A. M. Waszkielewicz et al.   CURRENT MEDICINAL CHEMISTRY

The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?

(2013) Stefan Trapp et al.   CURRENT OPINION IN PHARMACOLOGY

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

Nutrition and the Risk of Alzheimer's Disease

(2013) Nan Hu et al.   Biomed Research International

Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity

(2012) Akila De Silva et al.   Gut and Liver

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21

(2012) Holly A. Cyphert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

(2012) Juan C. García-Cañaveras et al.   JOURNAL OF LIPID RESEARCH

GLP-1 secretion by microglial cells and decreased CNS expression in obesity

(2012) Camilla Kappe et al.   Journal of Neuroinflammation

Waking Action of Ursodeoxycholic Acid (UDCA) Involves Histamine and GABAA Receptor Block

(2012) Yevgenij Yanovsky et al.   PLoS One

Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease

(2011) Charles Y. Shao et al.   ACTA NEUROPATHOLOGICA

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipid metabolism in mammalian tissues and its control by retinoic acid

(2011) M. Luisa Bonet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases

(2011) Gregor Lorbek et al.   FEBS Journal

An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

(2011) Ian B Jeffery et al.   GUT

Glucose and Insulin Induction of Bile Acid Synthesis

(2011) Tiangang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of short-term low- and high-fat diets on low-density lipoprotein particle size in normolipidemic subjects

(2011) Valérie Guay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Association of Alzheimer disease pathology with abnormal lipid metabolism: The Hisayama Study

(2011) T. Matsuzaki et al.   NEUROLOGY

The bile steroid chenodeoxycholate is a potent antagonist at NMDA and GABAA receptors

(2011) S.R. Schubring et al.   NEUROSCIENCE LETTERS

Diversity, biogenesis and function of microbial amyloids

(2011) Luz P. Blanco et al.   TRENDS IN MICROBIOLOGY

Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis

(2011) Shaun Mahony et al.   GENOME BIOLOGY

Review: Disruption of the Postsynaptic Density in Alzheimer’s Disease and Other Neurodegenerative Dementias

(2010) Yuesong Gong et al.   American Journal of Alzheimers Disease and Other Dementias

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Effect of Endogenous GLP-1 on Insulin Secretion in Type 2 Diabetes

(2010) M. Salehi et al.   DIABETES

Insulin Sensitivity and Glucose Tolerance Are Altered by Maintenance on a Ketogenic Diet

(2010) Kimberly P. Kinzig et al.   ENDOCRINOLOGY

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

(2010) Verena Keitel et al.   GLIA

Regulation of FGF21 Expression and Secretion by Retinoic Acid Receptor-related Orphan Receptor α

(2010) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Significance of vitamin A to brain function, behavior and learning

(2010) Christopher R. Olson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Sodium deoxycholate causes nitric oxide mediated DNA damage in oesophageal cells

(2009) Arthur J. Jolly et al.   FREE RADICAL RESEARCH

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

Rett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions

(2009) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Biphasic Regulation of Cell Death and Survival by Hydrophobic Bile Acids in HCT116 Cells

(2009) Satoko Yui et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Nuclear Receptors and Inflammatory Diseases

(2008) Kun Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

(2008) Denise M.O. Ramirez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Retinoic Acid Attenuates  -Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model

(2008) Y. Ding et al.   JOURNAL OF NEUROSCIENCE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Adipose tissue and skeletal muscle plasticity modulates metabolic health

(2008) Jozef Ukropec et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

(2003) Steven W. Barger et al.   JOURNAL OF NEUROCHEMISTRY