Article
Biology
Burcu Yuksel, Asuman Deveci Ozkan, Duygu Aydin, Zeynep Betts
Summary: This study evaluated the biochemical and genotoxic changes in cell death control caused by NaBu treatment in breast cancer cells. The results showed that NaBu inhibited cell proliferation and affected antioxidant enzymes and oxidative stress parameters, leading to increased DNA damage.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Oncology
Sarah Killcoyne, Rebecca C. Fitzgerald
Summary: Cancer cells evolve through DNA mutation, cell selection, and population expansion, driven by mutated driver genes and structural alterations to the genome. Early genomic instability in Barrett's esophagus (BE) may lead to esophageal adenocarcinoma (EAC). Understanding these patterns and genomic changes can improve early detection of EAC and provide insights into cancer evolution.
NATURE REVIEWS CANCER
(2021)
Article
Surgery
Alfredo Genco, Lidia Castagneto-Gissey, Loredana Gualtieri, Marcello Lucchese, Luca Leuratti, Emanuele Soricelli, Giovanni Casella
Summary: This study investigated the prevalence of GORD and associated oesophageal complications following different bariatric procedures. The findings showed that SG had the highest prevalence of erosive oesophagitis and Barrett's oesophagus, as well as a higher rate of biliary-like gastric stagnation and biliary-type reflux into the oesophagus compared to other procedures.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Nutrition & Dietetics
Sabrina E. Wang, Allison Hodge, S. Ghazaleh Dashti, Suzanne C. Dixon-Suen, Natalia Castano-Rodriguez, Robert Thomas, Graham Giles, Alex Boussioutas, Bradley Kendall, Dallas R. English
Summary: This study found that diet is a potential modifiable risk factor for Barrett's oesophagus (BE), the precursor of oesophageal adenocarcinoma. Higher intakes of leafy vegetables, fruit, dietary fiber, and carotenoids were inversely associated with BE risk, while higher intakes of discretionary food and total fat were positively associated with BE risk. No association was found for meat, protein, dairy products, or diet scores.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Environmental Sciences
Joao Luiz Coelho Ribas, Stefani Rossi, Gabrieli Limberger Galvan, William de Almeida, Marta Margarete Cestari, Helena C. Silva de Assis, Aleksander R. Zampronio
Summary: This study investigated the effects of Pb and TiO2 NPs alone or in combination on the macrophages of freshwater fish, naive or stimulated with LPS. Both Pb and TiO2 NPs reduced cell viability, but higher concentrations of NPs restored it. NO production was decreased by both substances, but the combination of Pb and TiO2 NPs prevented this reduction only at lower concentrations. Neither substance caused DNA fragmentation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Review
Gastroenterology & Hepatology
Rhonda F. Souza, Stuart J. Spechler
Summary: Barrett's esophagus, a precursor of esophageal adenocarcinoma, is characterized by metaplastic columnar mucosa lining a portion of the distal esophagus. It is believed to develop from progenitor cells at the esophagogastric junction that undergo epithelial-mesenchymal transition as part of a wound-healing process. Gastroesophageal reflux disease (GERD) plays a role in the development of Barrett's esophagus by inducing reprogramming of key transcription factors in the progenitor cells. Genome-wide association studies suggest a shared genetic susceptibility between Barrett's esophagus and its risk factors, such as GERD, obesity, and cigarette smoking.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, Rocco M. Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-oesophageal reflux is the main risk factor for Barrett's oesophagus, with alcohol consumption and hiatal hernia showing the strongest association with its development. Other potential risk factors such as smoking and obesity did not show significant correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Chemistry, Physical
Aida Jover, Jacobo Troncoso, Maria Chiara di Gregorio, Francisco Fraga Lopez
Summary: The thermodynamics of the transition between two supramolecular aggregates of sodium deoxycholate in aqueous solution were characterized in this study. The morphological transition between the two structures was observed using electron microscopy. The results indicated that the transition process was influenced by factors such as temperature, pH, and surfactant concentration.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Surgery
M. Yanes, G. Santoni, J. Maret-Ouda, E. Ness-Jensen, M. Farkkila, E. Lynge, E. Pukkala, P. Romundstad, L. Tryggvadottir, M. Von Euler Chelpin, J. Lagergren
Summary: The study showed that antireflux surgery with fundoplication is associated with lower mortality rates from all causes, cardiovascular disease, respiratory disease, laryngeal or pharyngeal cancer, and lung cancer in patients with reflux oesophagitis or Barrett's oesophagus, compared with antireflux medication. However, there was no difference in mortality rates from oesophageal cancer between the two treatment methods.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Biochemical Research Methods
M. Saravanan, S. Dhivakar, M. Mohapatra, S. Kutti Rani, K. Vijayakumaran
Summary: This study synthesized and characterized pyrene derivatives PM-PB and PM-TAB, and investigated their photophysical behavior in solvents. The sensitivity of these molecules towards the micellization process of bile salts was monitored using fluorescence methods, and they were effectively used to estimate the CMC of NaDC.
JOURNAL OF FLUORESCENCE
(2022)
Review
Gastroenterology & Hepatology
Yonne Peters, Evi van Grinsven, Peter D. Siersema
Summary: A positive family history of Barrett's oesophagus or oesophageal adenocarcinoma is a strong risk factor for both conditions, and can be a useful indicator for identifying high-risk individuals who may benefit from early detection strategies.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Surgery
L. Tullie, A. Kelay, G. S. Bethell, C. Major, N. J. Hall
Summary: Patients born with oesophageal atresia have a relatively high prevalence of Barrett's oesophagus, especially in those who undergo endoscopic screening or surveillance. Despite a limited number of cancers, there is a need to consider the necessity of screening and surveillance.
Article
Pharmacology & Pharmacy
Maomao Tang, Zhiping Gui, Xiao Liang, Chaoshuang Yan, Xiaoliang Li, Zhenbao Li, Ning He, Xiangwei Chang, Jian Guo, Shuangying Gui
Summary: The study improved the oral absorption of PF by preparing PF-loaded SDC-Lips, enhancing its pharmacokinetic parameters and showing potential in treating cardiovascular and cerebrovascular diseases.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Endocrinology & Metabolism
Vitalijs Borisovs, Jevgenijs Bodrenko, Jolanta Kalnina, Nikolajs Sjakste
Summary: Patients with multiple sclerosis have significantly higher levels of nitric oxide metabolites, oxidative stress biomarkers, modified DNA bases, nitrite, and nitrate in plasma and serum samples, while lower levels of malondialdehyde.
METABOLIC BRAIN DISEASE
(2021)
Article
Environmental Sciences
Sergey Petrovich Kukla, Valentina Vladimirovna Slobodskova, Elena Vladimirovna Zhuravel, Andrey Alexandrovich Mazur, Viktor Pavlovich Chelomin
Summary: The increase in the number of products containing nanoparticles (NPs) poses a real threat to the environment. Although the acute toxicity of most aquatic NPs has been well documented, there is relatively little research on the long-term effects of NPs on the reproductive system and gamete quality of aquatic organisms. In an experiment on the sand dollar, exposure to copper oxide nanoparticles (CuO NPs) resulted in copper accumulation in tissues, increased lipid peroxidation product concentrations, decreased fertilization rate, and increased sperm DNA damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Nutrition & Dietetics
Veronique Chajes, Lorna J. Gibson, Carine Biessy, Nadia Slimani, Gershim Asiki, Laure Dossus, Christopher P. Wild, Robert Newton
BRITISH JOURNAL OF NUTRITION
(2019)
Review
Oncology
Joachim Schuz, Carolina Espina, Christopher P. Wild
MOLECULAR ONCOLOGY
(2019)
Article
Nutrition & Dietetics
Charles J. P. Snart, Claire Keeble, Elizabeth Taylor, Janet E. Cade, Paul M. Stewart, Michael Zimmermann, Stephen Reid, Diane E. Threapleton, Lucilla Poston, Jenny E. Myers, Nigel A. B. Simpson, Darren C. Greenwood, Laura J. Hardie
Article
Cell Biology
Maimuna Mendy, Elodie Caboux, Christopher P. Wild, Rolando Herrero, Rosita Accardi-Gheit, Gary Clifford, Elisabeth Francon, Ausrele Kesminiene, James Mckay, Sabina Rinaldi, Augustin Scalbert, Ghislaine Scello, Eduardo Seleiro, Jiri Zavadil
BIOPRESERVATION AND BIOBANKING
(2019)
Article
Public, Environmental & Occupational Health
Darren C. Greenwood, Laura J. Hardie, Gary S. Frost, Nisreen A. Alwan, Kathryn E. Bradbury, Michelle Carter, Paul Elliott, Charlotte E. L. Evans, Heather E. Ford, Neil Hancock, Timothy J. Key, Bette Liu, Michelle A. Morris, Umme Z. Mulla, Katerina Petropoulou, Gregory D. M. Potter, Elio Riboli, Heather Young, Petra A. Wark, Janet E. Cade
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2019)
Review
Nutrition & Dietetics
Essra Noorwali, Laura Hardie, Janet Cade
Article
Oncology
Jonathan M. Samet, Weihsueh A. Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M. Lunn, Frederick A. Beland, Lisa Bero, Patience Browne, Lin Fritschi, Jun Kanno, Dirk W. Lachenmeier, Qing Lan, Gerard Lasfargues, Frank Le Curieux, Susan Peters, Pamela Shubat, Hideko Sone, Mary C. White, Jon Williamson, Marianna Yakubovskaya, Jack Siemiatycki, Paul A. White, Kathryn Z. Guyton, Mary K. Schubauer-Berigan, Amy L. Hall, Yann Grosse, Veronique Bouvard, Lamia Benbrahim-Tallaa, Fatiha El Ghissassi, Beatrice Lauby-Secretan, Bruce Armstrong, Rodolfo Saracci, Jiri Zavadil, Kurt Straif, Christopher P. Wild
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Article
Multidisciplinary Sciences
Jiyuan An, Puya Gharahkhani, Matthew H. Law, Jue-Sheng Ong, Xikun Han, Catherine M. Olsen, Rachel E. Neale, John Lai, Tom L. Vaughan, Anne C. Bohmer, Janusz Jankowski, Rebecca C. Fitzgerald, Johannes Schumacher, Claire Palles, David C. Whiteman, Stuart MacGregor, Marilie D. Gammon, Douglas A. Corley, Nicholas J. Shaheen, Nigel C. Bird, Laura J. Hardie, Liam J. Murray, Brian J. Reid, Wong-Ho Chow, Harvey A. Risch, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H. Wu, M. Agee, B. Alipanahi, A. Auton, R. K. Bell, K. Bryc, S. L. Elson, P. Fontanillas, N. A. Furlotte, D. A. Hinds, K. E. Huber, A. Kleinman, N. K. Litterman, M. H. McIntyre, J. L. Mountain, E. S. Noblin, C. A. M. Northover, S. J. Pitts, J. Fah Sathirapongsasuti, O. V. Sazonova, J. F. Shelton, S. Shringarpure, C. Tian, J. Y. Tung, V. Vacic, C. H. Wilson
NATURE COMMUNICATIONS
(2019)
Correction
Multidisciplinary Sciences
Jiyuan An, Puya Gharahkhani, Matthew H. Law, Jue-Sheng Ong, Xikun Han, Catherine M. Olsen, Rachel E. Neale, John Lai, Tom L. Vaughan, Ines Gockel, Rene Thieme, Anne C. Bohmer, Janusz Jankowski, Rebecca C. Fitzgerald, Johannes Schumacher, Claire Palles, Marilie D. Gammon, Douglas A. Corley, Nicholas J. Shaheen, Nigel C. Bird, Laura J. Hardie, Liam J. Murray, Brian J. Reid, Wong-Ho Chow, Harvey A. Risch, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H. Wu
NATURE COMMUNICATIONS
(2019)
Review
Nutrition & Dietetics
Huifeng Zhang, Laura Hardie, Areej O. Bawajeeh, Janet Cade
Article
Medicine, General & Internal
Charles Jonathan Peter Snart, Diane Erin Threapleton, Claire Keeble, Elizabeth Taylor, Dagmar Waiblinger, Stephen Reid, Nisreen A. Alwan, Dan Mason, Rafaq Azad, Janet Elizabeth Cade, Nigel A. B. Simpson, Sarah Meadows, Amanda McKillion, Gillian Santorelli, Amanda H. Waterman, Michael Zimmermann, Paul M. Stewart, John Wright, Mark Mon-Williams, Darren Charles Greenwood, Laura J. Hardie
Article
Nutrition & Dietetics
Diane E. Threapleton, Dagmar Waiblinger, Charles J. P. Snart, Elizabeth Taylor, Claire Keeble, Samina Ashraf, Shazia Bi, Ramzi Ajjan, Rafaq Azad, Neil Hancock, Dan Mason, Stephen Reid, Kirsten J. Cromie, Nisreen A. Alwan, Michael Zimmermann, Paul M. Stewart, Nigel A. B. Simpson, John Wright, Janet E. Cade, Laura J. Hardie, Darren C. Greenwood
Summary: This study in Bradford, UK, investigated the relationship between iodine intake in pregnant women and thyroid function, showing that intake was associated with markers such as urinary iodine concentration, thyroglobulin, and palpable goiter. High intake was linked to better thyroid health outcomes.
Meeting Abstract
Nutrition & Dietetics
Janet Cade, Petra Wark, Gary Frost, Nisreen Alwan, Michelle Carter, Paul Elliott, Heather Ford, Neil Hancock, Michelle Morris, Zeinab Mulla, Essra Noorwali, Aikaterini Petropoulou, Greg Potter, Elio Riboli, Laura Hardie, Darren Greenwood
PROCEEDINGS OF THE NUTRITION SOCIETY
(2020)
Meeting Abstract
Oncology
Christopher P. Wild
CANCER PREVENTION RESEARCH
(2020)
Meeting Abstract
Pathology
B. Abedi-Ardekani, D. Nasrollahzadeh, R. Njie, S. O. Bittaye, C. Carreira, M. Salieu Jallow, M. Almonte, C. P. Wild
