Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation

Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis

(2016) Bo Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Microbiota-induced obesity requires farnesoid X receptor

(2016) Ava Parséus et al.   GUT

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

(2016) Yang Xu et al.   HEPATOLOGY

Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of liver regeneration

(2016) Hui-Xin Liu et al.   JOURNAL OF HEPATOLOGY

Tumor-associated macrophage or chemokine ligand CCL17 positively regulates the tumorigenesis of hepatocellular carcinoma

(2016) Fangyu Zhu et al.   MEDICAL ONCOLOGY

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

(2016) Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisit dietary fiber on colorectal cancer: butyrate and its role on prevention and treatment

(2015) J. C. Encarnação et al.   CANCER AND METASTASIS REVIEWS

Bile acids as metabolic regulators

(2015) Tiangang Li et al.   CURRENT OPINION IN GASTROENTEROLOGY

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

MiR-22-silenced Cyclin A Expression in Colon and Liver Cancer Cells Is Regulated by Bile Acid Receptor

(2015) Fan Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implications of microbiota and bile acid in liver injury and regeneration

(2015) Hui-Xin Liu et al.   JOURNAL OF HEPATOLOGY

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Fat, fibre and cancer risk in African Americans and rural Africans

(2015) Stephen J. D. O’Keefe et al.   Nature Communications

Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration

(2015) Hui-Xin Liu et al.   Oncotarget

Diet shapes the gut microbiome of pigs during nursing and weaning

(2015) Steven A. Frese et al.   Microbiome

FXR and liver carcinogenesis

(2014) Xiong-fei Huang et al.   ACTA PHARMACOLOGICA SINICA

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer

(2014) Jessica Tsuei et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Desulfovibrio desulfuricansisolates from the gut of a single individual: Structural and biological lipid A characterization

(2014) Wei Zhang-Sun et al.   FEBS LETTERS

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis

(2014) Ying Hu et al.   MOLECULAR CANCER RESEARCH

Bacterial Bile Metabolising Gene Abundance in Crohn's, Ulcerative Colitis and Type 2 Diabetes Metagenomes

(2014) Alain Labbé et al.   PLoS One

Urinary Bile Acids as Biomarkers for Liver Diseases I. Stability of the Baseline Profile in Healthy Subjects

(2014) Sai Praneeth R. Bathena et al.   TOXICOLOGICAL SCIENCES

Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data

(2014) M. Vital et al.   mBio

A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

(2014) D. R. Donohoe et al.   Cancer Discovery

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance

(2013) Yongjie Ma et al.   PHARMACEUTICAL RESEARCH

Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice

(2013) Guodong Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma

(2012) Hongying Su et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

(2012) Juan C. García-Cañaveras et al.   JOURNAL OF LIPID RESEARCH

Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis inob/obMice

(2012) Yanqiao Zhang et al.   MOLECULAR ENDOCRINOLOGY

Hepatocarcinogenesis in FXR−/−Mice Mimics Human HCC Progression That Operates through HNF1α Regulation of FXR Expression

(2012) Nian Liu et al.   MOLECULAR ENDOCRINOLOGY

High Expression of CCL20 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma after Curative Resection

(2011) Xiangjiu Ding et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Increased Activation of the Wnt/ -Catenin Pathway in Spontaneous Hepatocellular Carcinoma Observed in Farnesoid X Receptor Knockout Mice

(2011) A. Wolfe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Age-Related Topographical Metabolic Signatures for the Rat Gastrointestinal Contents

(2011) Yuan Tian et al.   JOURNAL OF PROTEOME RESEARCH

Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

(2011) Roberto Berni Canani   WORLD JOURNAL OF GASTROENTEROLOGY

Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors

(2010) Hui Yang et al.   HEPATOLOGY

Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis

(2009) Sung Wook Seo et al.   BONE

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

ERK1/2 Activation Induced by Inflammatory Cytokines Compromises Effective Host Tissue Integration of Engineered Cartilage

(2009) Farida Djouad et al.   TISSUE ENGINEERING PART A

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA