The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

(2013) Xuezhi Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Measuring the specific activity of the protein tyrosine phosphatase Lyp

(2012) Rachel Bayley et al.   JOURNAL OF IMMUNOLOGICAL METHODS

PTPN22 Alters the Development of Regulatory T Cells in the Thymus

(2012) C. J. Maine et al.   JOURNAL OF IMMUNOLOGY

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

(2012) R. J. Brownlie et al.   Science Signaling

Rheumatoid arthritis susceptibility genes associate with lipid levels in patients with rheumatoid arthritis

(2011) T. E. Toms et al.   ANNALS OF THE RHEUMATIC DISEASES

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

(2011) Garth L. Burn et al.   FEBS LETTERS

Receptor-like Tyrosine Phosphatases CD45 and CD148 Have Distinct Functions in Chemoattractant-Mediated Neutrophil Migration and Response to S. aureus

(2011) Jing W. Zhu et al.   IMMUNITY

Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant

(2011) T. Habib et al.   JOURNAL OF IMMUNOLOGY

Neutrophil function in inflammation and inflammatory diseases

(2010) H. L. Wright et al.   RHEUMATOLOGY

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

(2009) Michelle L. Hermiston et al.   IMMUNOLOGICAL REVIEWS

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

(2009) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polymorphisms of the Endothelin-1 Gene Associate with Hypertension in Patients with Rheumatoid Arthritis

(2008) Vasileios F. Panoulas et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

(2008) Johanna Aarnisalo et al.   JOURNAL OF AUTOIMMUNITY

Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration

(2008) H. M. McGettrick et al.   JOURNAL OF LEUKOCYTE BIOLOGY