4.7 Review

The safety assessment of food ingredients derived from plant cell, tissue and organ cultures: A review

Journal

FOOD CHEMISTRY
Volume 176, Issue -, Pages 426-432

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2014.12.075

Keywords

Biosafety; Food ingredients; Phytochemicals; Plant cell tissue and organ culture products; Toxicological evaluation

Funding

  1. Korea healthcare technology R&D project, Ministry of Health and Welfare, Republic of Korea [A103017]
  2. Ministry of Education, Science and Technology, Republic of Korea for the award of Brain Pool Fellowship [131S-4-3-0523]
  3. Ministry of Science, ICT and Planning (MSIP)

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Plant cell, tissue and organ cultures (PCTOC) have become an increasingly attractive alternative for the production of various high molecular weight molecules which are used as flavourings, fragrances, colouring agents and food additives. Although PCTOC products are cultivated in vitro in a contamination free environment, the raw material produced from PCTOC may contain many components apart from the target compound. In some cases, PCTOC raw materials may also carry toxins, which may be naturally occurring or accumulated during the culture process. Assessment of the safety of PCTOC products is, therefore, a priority of the biotech industries involved in their production. The safety assessment involves the evaluation of starting material, production process and the end product. Before commercialisation, PCTOC products should be evaluated for their chemical and biological properties, as well as for their toxicity. In this review, measures and general criteria for biosafety evaluation of PCTOC products are addressed and thoroughly discussed. (C) 2014 Elsevier Ltd. All rights reserved.

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