Genetics of metastasis: melanoma and other cancers

Analysis of NRAS gain in 657 patients with melanoma and evaluation of its sensitivity to a MEK inhibitor

(2018) Junya Yan et al.   EUROPEAN JOURNAL OF CANCER

Comparative genomics reveals that loss of lunatic fringe (LFNG ) promotes melanoma metastasis

(2018) Martin Del Castillo Velasco-Herrera et al.   Molecular Oncology

Punctuated evolution of canonical genomic aberrations in uveal melanoma

(2018) Matthew G. Field et al.   Nature Communications

Focus on cutaneous and uveal melanoma specificities

(2017) Charlotte Pandiani et al.   GENES & DEVELOPMENT

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer

(2017) Shuan Rao et al.   GENES & DEVELOPMENT

Malignant melanoma of sun-protected sites: a review of clinical, histological, and molecular features

(2017) Emily A Merkel et al.   LABORATORY INVESTIGATION

Whole-genome landscapes of major melanoma subtypes

(2017) Nicholas K. Hayward et al.   NATURE

Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling

(2017) Ana Neto et al.   Pigment Cell & Melanoma Research

Systematic genomic and translational efficiency studies of uveal melanoma

(2017) Chelsea Place Johnson et al.   PLoS One

Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach

(2017) Rahul Metri et al.   Scientific Reports

Progression and metastasis of lung cancer

(2016) Helmut H. Popper   CANCER AND METASTASIS REVIEWS

Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas

(2016) Vinicius de Lima Vazquez et al.   MELANOMA RESEARCH

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

(2016) Amanda R Moore et al.   NATURE GENETICS

Metastasis as an evolutionary process

(2016) S. Turajlic et al.   SCIENCE

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

(2016) Yasmine A. Valentin-Vega et al.   Scientific Reports

Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen

(2015) G. N. Adams et al.   CANCER RESEARCH

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

RAC1 and Melanoma

(2015) Ruth Halaban   CLINICAL THERAPEUTICS

Driver KIT mutations in melanoma cluster in four hotspots

(2015) Nicolas Dumaz et al.   MELANOMA RESEARCH

Genetics of familial melanoma: 20 years afterCDKN2A

(2015) Lauren G. Aoude et al.   Pigment Cell & Melanoma Research

RAC1 P29S regulates PD-L1 expression in melanoma

(2015) Ha Linh Vu et al.   Pigment Cell & Melanoma Research

Functional screen identifies kinases driving prostate cancer visceral and bone metastasis

(2015) Claire M. Faltermeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination

(2015) J. Zachary Sanborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4

(2015) Peter Johansson et al.   Oncotarget

A highly recurrent RPS27 5’UTR mutation in melanoma

(2015) Ken Dutton-Regester et al.   Oncotarget

Pathways and therapeutic targets in melanoma

(2015) Emma Shtivelman et al.   Oncotarget

Acral Lentiginous Melanoma

(2014) Jin Yong Kim et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

(2014) J. Xu et al.   CANCER RESEARCH

Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair

(2014) I. H. Ismail et al.   CANCER RESEARCH

MITF in melanoma: mechanisms behind its expression and activity

(2014) Mariusz L. Hartman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TERTpromoter mutation is uncommon in acral lentiginous melanoma

(2014) Jau-Yu Liau et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Somatic Mutation of GRIN2A in Malignant Melanoma Results in Loss of Tumor Suppressor Activity via Aberrant NMDAR Complex Formation

(2014) Todd D. Prickett et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TERT and AURKA Gene Copy Number Gains Enhance the Detection of Acral Lentiginous Melanomas by Fluorescence in Situ Hybridization

(2014) Alba Diaz et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

The mutational burden of acral melanoma revealed by whole-genome sequencing and comparative analysis

(2014) Simon J. Furney et al.   Pigment Cell & Melanoma Research

Clonal Architectures and Driver Mutations in Metastatic Melanomas

(2014) Li Ding et al.   PLoS One

Regulation of invadopodia by the tumor microenvironment

(2014) Christine M Gould et al.   Cell Adhesion & Migration

BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma

(2013) Katie A Matatall et al.   BMC CANCER

Conjunctival Melanomas Harbor BRAF and NRAS Mutations and Copy Number Changes Similar to Cutaneous and Mucosal Melanomas

(2013) K. G. Griewank et al.   CLINICAL CANCER RESEARCH

Large-scale Analysis of PDGFRA Mutations in Melanomas and Evaluation of Their Sensitivity to Tyrosine Kinase Inhibitors Imatinib and Crenolanib

(2013) J. Dai et al.   CLINICAL CANCER RESEARCH

High rate of FGFR1 amplifications in brain metastases of squamous and non-squamous lung cancer

(2013) Matthias Preusser et al.   LUNG CANCER

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

(2013) Juxiang Cao et al.   MOLECULAR CELL

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

(2013) Marcel Martin et al.   NATURE GENETICS

Genome-Wide Identification of Bone Metastasis-Related MicroRNAs in Lung Adenocarcinoma by High-Throughput Sequencing

(2013) Lin Xie et al.   PLoS One

Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo

(2013) Ling Wang et al.   PLoS One

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications

(2013) Reuben S Harris   Genome Medicine

Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling

(2013) B. R. Achyut et al.   PLoS Genetics

Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma

(2012) Jared J Gartner et al.   BMC GENOMICS

Genomics screens for metastasis genes

(2012) Jinchun Yan et al.   CANCER AND METASTASIS REVIEWS

DNA methylome alterations in chemical carcinogenesis

(2012) Igor P. Pogribny et al.   CANCER LETTERS

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

(2012) L. C. W. Vredeveld et al.   GENES & DEVELOPMENT

Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression

(2012) Brian F. Zamarron et al.   International Journal of Biological Sciences

BRAF/NRASMutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma

(2012) Maria Colombino et al.   JOURNAL OF CLINICAL ONCOLOGY

Melanoma genome sequencing reveals frequent PREX2 mutations

(2012) Michael F. Berger et al.   NATURE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

MDM4 is a key therapeutic target in cutaneous melanoma

(2012) Agnieszka Gembarska et al.   NATURE MEDICINE

Collaborative Ocular Oncology Group Report Number 1: Prospective Validation of a Multi-Gene Prognostic Assay in Uveal Melanoma

(2012) Michael D. Onken et al.   OPHTHALMOLOGY

Novel Somatic Mutations to PI3K Pathway Genes in Metastatic Melanoma

(2012) Austin Y. Shull et al.   PLoS One

P-Cadherin Promotes Liver Metastasis and Is Associated with Poor Prognosis in Colon Cancer

(2011) Lichao Sun et al.   AMERICAN JOURNAL OF PATHOLOGY

NRAS mutation status is an independent prognostic factor in metastatic melanoma

(2011) John A. Jakob et al.   CANCER

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance

(2011) Yvonne Chao et al.   CLINICAL & EXPERIMENTAL METASTASIS

Comparison of 17,641 Patients With Right- and Left-Sided Colon Cancer: Differences in Epidemiology, Perioperative Course, Histology, and Survival

(2011) Frank Benedix et al.   DISEASES OF THE COLON & RECTUM

Whole genome sequencing of matched primary and metastatic acral melanomas

(2011) S. Turajlic et al.   GENOME RESEARCH

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(2011) Murielle Mimeault et al.   MOLECULAR MEDICINE

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

(2011) Satoru Yokoyama et al.   NATURE

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

(2011) Corine Bertolotto et al.   NATURE

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma

(2011) Todd D Prickett et al.   NATURE GENETICS

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Germline mutations in BAP1 predispose to melanocytic tumors

(2011) Thomas Wiesner et al.   NATURE GENETICS

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

The tumor microenvironment

(2011) Cynthia E. Weber et al.   SURGICAL ONCOLOGY-OXFORD

Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics

(2010) Scott E. Woodman et al.   BIOCHEMICAL PHARMACOLOGY

Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?

(2010) József Tímár et al.   CLINICAL & EXPERIMENTAL METASTASIS

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prognostic significance of BRMS1 expression in human melanoma and its role in tumor angiogenesis

(2010) J Li et al.   ONCOGENE

Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexes

(2010) S Tabariès et al.   ONCOGENE

Integrative Genome Comparison of Primary and Metastatic Melanomas

(2010) Omar Kabbarah et al.   PLoS One

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

(2009) Nathalie Dhomen et al.   CANCER CELL

Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility

(2009) Silvia Giampieri et al.   NATURE CELL BIOLOGY

Frequent mutations in the MITF pathway in melanoma

(2009) Julia C. Cronin et al.   Pigment Cell & Melanoma Research

A novel AKT3 mutation in melanoma tumours and cell lines

(2008) M A Davies et al.   BRITISH JOURNAL OF CANCER

Regulation of In Situ to Invasive Breast Carcinoma Transition

(2008) Min Hu et al.   CANCER CELL

A Novel Lung Cancer Signature Mediates Metastatic Bone Colonization by a Dual Mechanism

(2008) S. Vicent et al.   CANCER RESEARCH

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Molecular Pathways Mediating Liver Metastasis in Patients with Uveal Melanoma

(2008) S. Bakalian et al.   CLINICAL CANCER RESEARCH

Functions of Normal and Malignant Prostatic Stem/Progenitor Cells in Tissue Regeneration and Cancer Progression and Novel Targeting Therapies

(2008) Murielle Mimeault et al.   ENDOCRINE REVIEWS

Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells

(2008) E Spaeth et al.   GENE THERAPY

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE