Focus on cutaneous and uveal melanoma specificities

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

(2017) Paola Falletta et al.   GENES & DEVELOPMENT

Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression

(2017) Caroline Bonet et al.   JNCI-Journal of the National Cancer Institute

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

(2017) Louise van der Weyden et al.   NATURE

Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression

(2017) Caroline Bonet et al.   JNCI-Journal of the National Cancer Institute

Anti-PD1 treatment in metastatic uveal melanoma in the Netherlands

(2016) M. K. van der Kooij et al.   ACTA ONCOLOGICA

Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing

(2016) Beryl Royer-Bertrand et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Uveal melanoma: From diagnosis to treatment and the science in between

(2016) Chandrani Chattopadhyay et al.   CANCER

Clinical outcomes in metastatic uveal melanoma treated with PD-1 and PD-L1 antibodies

(2016) Alain P. Algazi et al.   CANCER

ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma

(2016) Jae Hyuk Yoo et al.   CANCER CELL

PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma

(2016) M. G. Field et al.   CLINICAL CANCER RESEARCH

Ipilimumab Combined with Nivolumab: A Standard of Care for the Treatment of Advanced Melanoma?

(2016) Matteo S. Carlino et al.   CLINICAL CANCER RESEARCH

Survival of patients with advanced metastatic melanoma: The impact of novel therapies

(2016) Selma Ugurel et al.   EUROPEAN JOURNAL OF CANCER

The use of pembrolizumab for the treatment of metastatic uveal melanoma

(2016) Lisa A. Kottschade et al.   MELANOMA RESEARCH

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

(2016) Amanda R Moore et al.   NATURE GENETICS

Uveal Melanomas with SF3B1 Mutations

(2016) Serdar Yavuzyigitoglu et al.   OPHTHALMOLOGY

The genomic landscape of cutaneous melanoma

(2016) Tongwu Zhang et al.   Pigment Cell & Melanoma Research

Derepression ofhTERTgene expression promotes escape from oncogene-induced cellular senescence

(2016) Priyanka L. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

(2016) Samar Alsafadi et al.   Nature Communications

Genetic markers of pigmentation are novel risk loci for uveal melanoma

(2016) Robert Ferguson et al.   Scientific Reports

Driver Mutations in Uveal Melanoma

(2016) Christina L. Decatur et al.   JAMA Ophthalmology

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

New Strategies in Melanoma: Entering the Era of Combinatorial Therapy

(2015) R. J. Sullivan et al.   CLINICAL CANCER RESEARCH

The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma

(2015) Kathleen M. Mahoney et al.   CLINICAL THERAPEUTICS

Genetically modified T cells in cancer therapy: opportunities and challenges

(2015) M. Sharpe et al.   Disease Models & Mechanisms

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts

(2015) K. Kemper et al.   EMBO Molecular Medicine

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas

(2015) Michael Krauthammer et al.   NATURE GENETICS

Recurrent inactivating RASA2 mutations in melanoma

(2015) Rand Arafeh et al.   NATURE GENETICS

Anti-PD-1 therapies—a new first-line option in advanced melanoma

(2015) Ryan J. Sullivan et al.   Nature Reviews Clinical Oncology

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

(2015) A Sveen et al.   ONCOGENE

Genetics of familial melanoma: 20 years afterCDKN2A

(2015) Lauren G. Aoude et al.   Pigment Cell & Melanoma Research

Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism

(2015) Mark J. de Lange et al.   PLoS One

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity

(2015) Alejandro Conde-Perez et al.   Nature Communications

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

(2015) Annelien Verfaillie et al.   Nature Communications

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment

(2015) Stefanie Riesenberg et al.   Nature Communications

Clinical Characteristics of Uveal Melanoma in Patients With GermlineBAP1Mutations

(2015) Mrinali P. Gupta et al.   JAMA Ophthalmology

Digital PCR Validates 8q Dosage as Prognostic Tool in Uveal Melanoma

(2015) Mieke Versluis et al.   PLoS One

Pathways and therapeutic targets in melanoma

(2015) Emma Shtivelman et al.   Oncotarget

PD-1 and PD-L1 antibodies for melanoma

(2015) Katy K Tsai et al.   Human Vaccines & Immunotherapeutics

The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia

(2014) Boris C. Bastian   Annual Review of Pathology-Mechanisms of Disease

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair

(2014) I. H. Ismail et al.   CANCER RESEARCH

Recent developments in prognostic and predictive testing in uveal melanoma

(2014) Matthew G. Field et al.   CURRENT OPINION IN OPHTHALMOLOGY

Effect of Selumetinib vs Chemotherapy on Progression-Free Survival in Uveal Melanoma

(2014) Richard D. Carvajal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

(2014) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

(2014) Lise Boussemart et al.   NATURE

Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma

(2014) Georgina V. Long et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell gene expression signatures reveal melanoma cell heterogeneity

(2014) M Ennen et al.   ONCOGENE

Mimulone-Induced Autophagy through p53-Mediated AMPK/mTOR Pathway Increases Caspase-Mediated Apoptotic Cell Death in A549 Human Lung Cancer Cells

(2014) Hyun-Kyu An et al.   PLoS One

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

(2014) Judith Müller et al.   Nature Communications

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

(2014) D. J. Konieczkowski et al.   Cancer Discovery

BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma

(2013) Katie A Matatall et al.   BMC CANCER

Conjunctival Melanomas Harbor BRAF and NRAS Mutations and Copy Number Changes Similar to Cutaneous and Mucosal Melanomas

(2013) K. G. Griewank et al.   CLINICAL CANCER RESEARCH

The neural crest

(2013) R. Mayor et al.   DEVELOPMENT

A New KIT Mutation (N505I) in Acral Melanoma Confers Constitutive Signaling, Favors Tumorigenic Properties, and Is Sensitive to Imatinib

(2013) Maryline Allegra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma

(2013) Flore Nallet-Staub et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

(2013) Juxiang Cao et al.   MOLECULAR CELL

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

(2013) Cory M. Johannessen et al.   NATURE

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

(2013) Marcel Martin et al.   NATURE GENETICS

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma

(2013) J William Harbour et al.   NATURE GENETICS

The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma

(2013) Howard L. Kaufman et al.   Nature Reviews Clinical Oncology

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma

(2013) S. J. Furney et al.   Cancer Discovery

Misregulation of Pre-mRNA Alternative Splicing in Cancer

(2013) J. Zhang et al.   Cancer Discovery

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

(2013) E. M. Van Allen et al.   Cancer Discovery

Concurrent MEK2 Mutation and BRAF Amplification Confer Resistance to BRAF and MEK Inhibitors in Melanoma

(2013) Jessie Villanueva et al.   Cell Reports

Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications

(2013) Reuben S Harris   Genome Medicine

GNAQ and GNA11 mutations in melanocytomas of the central nervous system

(2012) Rajmohan Murali et al.   ACTA NEUROPATHOLOGICA

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Conjunctival melanoma and melanocytic intra-epithelial neoplasia

(2012) N Kenawy et al.   EYE

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

(2012) L. C. W. Vredeveld et al.   GENES & DEVELOPMENT

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

(2012) Jennifer Landsberg et al.   NATURE

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

(2012) Devarati Mitra et al.   NATURE

Melanoma genome sequencing reveals frequent PREX2 mutations

(2012) Michael F. Berger et al.   NATURE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Pathology and genetics of uveal melanoma

(2012) Klaus G. Griewank et al.   PATHOLOGY

Prevalence of the E318K MITF germline mutation in Italian melanoma patients: associations with histological subtypes and family cancer history

(2012) P. Ghiorzo et al.   Pigment Cell & Melanoma Research

Novel Somatic Mutations to PI3K Pathway Genes in Metastatic Melanoma

(2012) Austin Y. Shull et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

(2011) William E. Damsky et al.   CANCER CELL

Ipilimumab in pretreated patients with metastatic uveal melanoma: safety and clinical efficacy

(2011) Riccardo Danielli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Histone Deacetylase Inhibitors Induce Growth Arrest and Differentiation in Uveal Melanoma

(2011) S. Landreville et al.   CLINICAL CANCER RESEARCH

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

KIT as a Therapeutic Target in Metastatic Melanoma

(2011) Richard D. Carvajal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

(2011) Satoru Yokoyama et al.   NATURE

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

(2011) Corine Bertolotto et al.   NATURE

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

(2011) Xiaomu Wei et al.   NATURE GENETICS

Germline mutations in BAP1 predispose to melanocytic tumors

(2011) Thomas Wiesner et al.   NATURE GENETICS

Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

(2011) T Strub et al.   ONCOGENE

Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny

(2011) Y Cheli et al.   ONCOGENE

PIK3CA Mutations Frequently Coexist with RAS and BRAF Mutations in Patients with Advanced Cancers

(2011) Filip Janku et al.   PLoS One

Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT2) receptor

(2010) F Wunder et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microphthalmia-Associated Transcription Factor Controls the DNA Damage Response and a Lineage-Specific Senescence Program in Melanomas

(2010) Sandy Giuliano et al.   CANCER RESEARCH

Genotypic Profiling of 452 Choroidal Melanomas with Multiplex Ligation-Dependent Probe Amplification

(2010) B. Damato et al.   CLINICAL CANCER RESEARCH

Association between Gene Expression Profile, Proliferation and Metastasis in Uveal Melanoma

(2010) Michael D. Onken et al.   CURRENT EYE RESEARCH

An Accurate, Clinically Feasible Multi-Gene Expression Assay for Predicting Metastasis in Uveal Melanoma

(2010) Michael D. Onken et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influence of Immune Privilege on Ocular Tumor Development

(2010) Kyle C. McKenna et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo and correlates with poor survival in colorectal cancer patients

(2010) T Müller et al.   ONCOGENE

Prognosis of Uveal Melanoma in 500 Cases Using Genetic Testing of Fine-Needle Aspiration Biopsy Specimens

(2010) Carol L. Shields et al.   OPHTHALMOLOGY

Conjunctival Melanoma

(2010) Carol L. Shields et al.   OPHTHALMOLOGY

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

Time trends in the incidence of conjunctival melanoma in Sweden

(2009) E Triay et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

(2009) Nathalie Dhomen et al.   CANCER CELL

Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin

(2009) Igor Adameyko et al.   CELL

Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes

(2009) H. Aoki et al.   DEVELOPMENT

Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers

(2009) Mark D. Levin et al.   JOURNAL OF CLINICAL INVESTIGATION

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Genetics of human iris colour and patterns

(2009) Richard A. Sturm et al.   Pigment Cell & Melanoma Research

Fifteen-year quest for microphthalmia-associated transcription factor target genes

(2009) Yann Cheli et al.   Pigment Cell & Melanoma Research

MEK1 mutations confer resistance to MEK and B-RAF inhibition

(2009) C. M. Emery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

(2009) B. Fine et al.   SCIENCE

A novel AKT3 mutation in melanoma tumours and cell lines

(2008) M A Davies et al.   BRITISH JOURNAL OF CANCER

In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States

(2008) K. S. Hoek et al.   CANCER RESEARCH

Integrative Genomic Analysis of Aneuploidy in Uveal Melanoma

(2008) J. P. Ehlers et al.   CLINICAL CANCER RESEARCH

Molecular Pathways Mediating Liver Metastasis in Patients with Uveal Melanoma

(2008) S. Bakalian et al.   CLINICAL CANCER RESEARCH

KIT Gene Mutations and Copy Number in Melanoma Subtypes

(2008) C. Beadling et al.   CLINICAL CANCER RESEARCH

The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

(2008) E Wisse et al.   GENE THERAPY

Sunlight ultraviolet irradiation andBRAFV600 mutagenesis in human melanoma

(2008) Ahmad Besaratinia et al.   HUMAN MUTATION

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE

C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

(2008) D Zhuang et al.   ONCOGENE