Ligand libraries for high throughput screening of homogeneous catalysts

Evolving artificial metalloenzymes via random mutagenesis

(2018) Hao Yang et al.   Nature Chemistry

A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow

(2018) Damith Perera et al.   SCIENCE

Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature

(2017) Loorthuraja Rasu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective, Enzymatic C–H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor

(2017) Paweł Dydio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction

(2017) Patrick S. Fier et al.   ORGANIC LETTERS

Nickel-Catalyzed Synthesis of Quinazolinediones

(2017) Gregory L. Beutner et al.   ORGANIC LETTERS

Combinatorial Nickel-Catalyzed Monofluoroalkylation of Aryl Boronic Acids with Unactivated Fluoroalkyl Iodides

(2017) Jie Sheng et al.   ORGANIC LETTERS

An Evaluation of Multiple Catalytic Systems for the Cyanation of 2,3-Dichlorobenzoyl Chloride: Application to the Synthesis of Lamotrigine

(2017) David C. Leitch et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Snap deconvolution: An informatics approach to high-throughput discovery of catalytic reactions

(2017) Konstantin Troshin et al.   SCIENCE

High-Throughput Automation in Chemical Process Development

(2017) Joshua A. Selekman et al.   Annual Review of Chemical and Biomolecular Engineering

Reaction discovery using acetylene gas as the chemical feedstock accelerated by the “stop-flow” micro-tubing reactor system

(2017) Fei Xue et al.   Chemical Science

Practical High-Throughput Experimentation for Chemists

(2017) Michael Shevlin   ACS Medicinal Chemistry Letters

Regioselective Synthesis of 2-Substituted Indoles from Benzotriazoles and Alkynes by Photoinitiated Denitrogenation

(2017) Michael Teders et al.   ACS Catalysis

Iron-Catalyzed Reductive Cyclization of o-Nitrostyrenes Using Phenylsilane as the Terminal Reductant

(2017) Michael Shevlin et al.   ACS Catalysis

High-throughput evaluation of in situ-generated cobalt(iii) catalysts for acyl fluoride synthesis

(2017) Graham M. Lee et al.   Catalysis Science & Technology

Small-Molecule Systems Chemistry

(2017) Ognjen Š. Miljanić   Chem

Catalyst selection by transition state affinity chromatography—An assessment

(2017) Anh T. Tran et al.   Molecular Catalysis

The Development of Multidimensional Analysis Tools for Asymmetric Catalysis and Beyond

(2016) Matthew S. Sigman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology: Challenges and Opportunities

(2016) Tillmann Heinisch et al.   ACCOUNTS OF CHEMICAL RESEARCH

Feedback in Flow for Accelerated Reaction Development

(2016) Brandon J. Reizman et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Mixed Ligand Approach for the Asymmetric Hydrogenation of 2-Substituted Pyridinium Salts

(2016) Marc Renom-Carrasco et al.   ADVANCED SYNTHESIS & CATALYSIS

Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions

(2016) Todd K. Hyster et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Accelerated Discovery in Photocatalysis using a Mechanism-Based Screening Method

(2016) Matthew N. Hopkinson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Riding the Wave of Monodentate Ligand Revival: From the A/B Concept to Noncovalent Interactions

(2016) Luca Pignataro et al.   CHEMICAL RECORD

Asymmetric Hydrogenation of 3-Substituted Pyridinium Salts

(2016) Marc Renom-Carrasco et al.   CHEMISTRY-A EUROPEAN JOURNAL

Modular solid-phase synthesis, catalytic application and efficient recycling of supported phosphine–phosphite ligand libraries

(2016) Frank J. L. Heutz et al.   DALTON TRANSACTIONS

Advances in high-throughput and high-efficiency chiral liquid chromatographic separations

(2016) Darshan C. Patel et al.   JOURNAL OF CHROMATOGRAPHY A

Nickel-Catalyzed Asymmetric Alkene Hydrogenation of α,β-Unsaturated Esters: High-Throughput Experimentation-Enabled Reaction Discovery, Optimization, and Mechanistic Elucidation

(2016) Michael Shevlin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiroptical Asymmetric Reaction Screening via Multicomponent Self-Assembly

(2016) Zeus A. De los Santos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Abiological catalysis by artificial haem proteins containing noble metals in place of iron

(2016) Hanna M. Key et al.   NATURE

Directed evolution of artificial metalloenzymes for in vivo metathesis

(2016) Markus Jeschek et al.   NATURE

New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries

(2016) Eric C. Hansen et al.   Nature Chemistry

High-Throughput Screening Protocol for the Coupling Reactions of Aryl Halides Using a Colorimetric Chemosensor for Halide Ions

(2016) Min Sik Eom et al.   ORGANIC LETTERS

Optimizing the Heck–Matsuda Reaction in Flow with a Constraint-Adapted Direct Search Algorithm

(2016) Daniel Cortés-Borda et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

An artificial metalloenzyme with the kinetics of native enzymes

(2016) P. Dydio et al.   SCIENCE

Reaction screening in continuous flow reactors

(2016) Dara Khairunnisa Binte Mohamed et al.   TETRAHEDRON LETTERS

Solid-Phase Synthesis and Catalytic Screening of Polystyrene Supported Diphosphines

(2016) M. C. Samuels et al.   TOPICS IN CATALYSIS

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods

(2016) Peter S. Kutchukian et al.   Chemical Science

Chirality imprinting and direct asymmetric reaction screening using a stereodynamic Brønsted/Lewis acid receptor

(2016) Keith W. Bentley et al.   Nature Communications

Miniature high-throughput chemosensing of yield, ee, and absolute configuration from crude reaction mixtures

(2016) K. W. Bentley et al.   Science Advances

Fast colorimetric screening for visible light photocatalytic oxidation and reduction reactions

(2016) Michal Poznik et al.   Reaction Chemistry & Engineering

Mass Spectrometric Screening of Racemic Amine Catalysts for Enantioselective Michael Additions

(2015) Florian Bächle et al.   ADVANCED SYNTHESIS & CATALYSIS

Artificial Metalloenzymes in Asymmetric Catalysis: Key Developments and Future Directions

(2015) Oscar Pàmies et al.   ADVANCED SYNTHESIS & CATALYSIS

Combinatorial Strategies to find New Catalysts for Asymmetric Hydrogenation Based on the Versatile Coordination Chemistry of METAMORPhos Ligands

(2015) Frédéric G. Terrade et al.   ChemCatChem

Enzyme immunoassays as screening tools for catalysts and reaction discovery

(2015) Christophe Créminon et al.   CHEMICAL COMMUNICATIONS

DNA-based hybrid catalysis

(2015) Ana Rioz-Martínez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides

(2015) Hongming Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic, Asymmetric, and Stereodivergent Synthesis of Non-Symmetric β,β-Diaryl-α-Amino Acids

(2015) Carmela Molinaro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simultaneous Chirality Sensing of Multiple Amines by 19F NMR

(2015) Yanchuan Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast screening of analytes for chemical reactions by reactive low-temperature plasma ionization mass spectrometry

(2015) Wei Zhang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

A data-intensive approach to mechanistic elucidation applied to chiral anion catalysis

(2015) A. Milo et al.   SCIENCE

Design of supramolecular chiral ligands for asymmetric metal catalysis

(2015) Kohsuke Ohmatsu et al.   TETRAHEDRON LETTERS

Identifying lead hits in catalyst discovery by screening and deconvoluting complex mixtures of catalyst components

(2015) Eléna Wolf et al.   Chemical Science

Automatic discovery and optimization of chemical processes

(2015) Claudia Houben et al.   Current Opinion in Chemical Engineering

DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

(2014) Raphael M. Franzini et al.   ACCOUNTS OF CHEMICAL RESEARCH

Late-Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

(2014) Daniel A. DiRocco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Hydrogenation of Pyridinium Salts with an Iridium Phosphole Catalyst

(2014) Mingxin Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Design: Toward Functional Metalloenzymes

(2014) Fangting Yu et al.   CHEMICAL REVIEWS

Combinatorial Approach to Chiral Tris-ligated Carbophilic Platinum Complexes: Application to Asymmetric Catalysis

(2014) Alexandre Pradal et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mixed-Ligand Catalysts: A Powerful Tool in Transition-Metal-Catalyzed Cross-Coupling Reactions

(2014) Yuting Fan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Impact of High Throughput Experimentation on Homogeneous Catalysis Research

(2014) David D. Devore et al.   COMMENTS ON INORGANIC CHEMISTRY

Neutralizing the Detrimental Effect of Glutathione on Precious Metal Catalysts

(2014) Yvonne M. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Contemporary screening approaches to reaction discovery and development

(2014) Karl D. Collins et al.   Nature Chemistry

Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications

(2014) Steven A. Weissman et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

(2014) A. Buitrago Santanilla et al.   SCIENCE

A tripodal peptide ligand for asymmetric Rh(ii) catalysis highlights unique features of on-bead catalyst development

(2014) Ramya Sambasivan et al.   Chemical Science

In situ generation of ion-paired chiral ligands: rapid identification of the optimal ligand for palladium-catalyzed asymmetric allylation

(2014) Kohsuke Ohmatsu et al.   Chemical Science

Rhodium(I)-Catalyzed Enantioselective Hydrogenation of Substituted Acrylic Acids with Sterically Similar β,β-Diaryls

(2013) Yang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Supramolecular catalysis. Part 1: non-covalent interactions as a tool for building and modifying homogeneous catalysts

(2013) Matthieu Raynal et al.   CHEMICAL SOCIETY REVIEWS

Supramolecular catalysis. Part 2: artificial enzyme mimics

(2013) Matthieu Raynal et al.   CHEMICAL SOCIETY REVIEWS

Studies of Asymmetric StyreneCyclopropanation with a Rhodium(II) Metallopeptide Catalyst Developed with a High-Throughput Screen

(2013) Ramya Sambasivan et al.   CHIRALITY

Dynamic Combinatorial Chemistry in Chemical Catalysis

(2013) Paweł Dydio et al.   ISRAEL JOURNAL OF CHEMISTRY

High-Throughput Optimization of Ir-Catalyzed C–H Borylation: A Tutorial for Practical Applications

(2013) Sean M. Preshlock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry

(2013) Jianwei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Label-assisted mass spectrometry for the acceleration of reaction discovery and optimization

(2013) Jaime R. Cabrera-Pardo et al.   Nature Chemistry

In vitro evolution of a Friedel–Crafts deoxyribozyme

(2013) Utpal Mohan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

(2013) Cheol K. Chung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts

(2013) M. R. Friedfeld et al.   SCIENCE

Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis

(2013) Jared C. Lewis   ACS Catalysis

Evolutionary Catalyst Screening: Iridium-Catalyzed Imine Hydrogenation

(2012) Alexander M. Kluwer et al.   ADVANCED SYNTHESIS & CATALYSIS

Screening Rhodium Metallopeptide Libraries “On Bead”: Asymmetric Cyclopropanation and a Solution to the Enantiomer Problem

(2012) Ramya Sambasivan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric catalysis based on tropos ligands

(2012) Kohsuke Aikawa et al.   CHEMICAL COMMUNICATIONS

A simple, fast, and easy assay for transition metal-catalyzed coupling reactions using a paper-based colorimetric iodide sensor

(2012) Sudeok Kim et al.   CHEMICAL COMMUNICATIONS

Directed evolution: tailoring biocatalysts for industrial applications

(2012) Ashwani Kumar et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Supramolecular Self-Assembled Ligands in Asymmetric Transition Metal Catalysis

(2012) Rosalba Bellini et al.   ISRAEL JOURNAL OF CHEMISTRY

Application of rapidly generated bidentate ligand libraries to zinc catalyzed reductions

(2012) Tariq Zaman et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

The power of pairing

(2012) Hajime Ito   Nature Chemistry

Artificial chirogenesis: a gateway to new opportunities in material science and catalysis

(2012) Martha V. Escárcega-Bobadilla et al.   Chemical Science

Ligand Scaffold Optimization of a Supramolecular Hydrogenation Catalyst: Analyzing the Influence of Key Structural Subunits on Reactivity and Selectivity

(2012) Nathan C. Thacker et al.   ACS Catalysis

Selection of Chiral Zinc Catalysts for the Kinetic Resolution of Esters via Dynamic Templating

(2012) R. Kannappan et al.   ACS Combinatorial Science

The application of “backdoor induction” in bioinspired asymmetric catalysis

(2012) Zoran Kokan et al.   RSC Advances

Two-stage optimization of a supramolecular catalyst for catalytic asymmetric hydroboration

(2011) Shin A. Moteki et al.   CHEMICAL COMMUNICATIONS

Rapid determination of enantiomeric excess: a focus on optical approaches

(2011) Diana Leung et al.   CHEMICAL SOCIETY REVIEWS

Supramolecular ligand–ligand and ligand–substrate interactions for highly selective transition metal catalysis

(2011) Stefano Carboni et al.   DALTON TRANSACTIONS

New chiral Schiff base–zinc complexes and their esterolytic catalytic activity

(2011) Ramu Kannappan et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

“Cofactor”-Controlled Enantioselective Catalysis

(2011) Paweł Dydio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Supramolecular Catalysis Induced by Remote Chiral Diols

(2011) Piet W. N. M. van Leeuwen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Determining the Enantioselectivity of Chiral Catalysts by Mass Spectrometric Screening of Their Racemic Forms

(2011) Christian Ebner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid, in situ synthesis of bidentate ligands: chromatography-free generation of catalyst libraries

(2011) Robin Frauenlob et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Discovery of an  -Amino C-H Arylation Reaction Using the Strategy of Accelerated Serendipity

(2011) A. McNally et al.   SCIENCE

A Simple, Multidimensional Approach to High-Throughput Discovery of Catalytic Reactions

(2011) D. W. Robbins et al.   SCIENCE

Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions

(2010) Manfred T. Reetz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High Throughput Screening and Evolution of a Library of Ligands in Asymmetric H-Transfer Reduction of Acetophenone

(2010) Radwan Abdallah et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Evolution of Metal Complex-Catalysts by Dynamic Templating with Transition State Analogs

(2010) Masaomi Matsumoto et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Dynamic Approaches towards Catalyst Discovery

(2010) Giulio Gasparini et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers

(2010) Jennifer L. Treece et al.   JOURNAL OF ORGANIC CHEMISTRY

Rapid Catalyst Screening by a Continuous-Flow Microreactor Interfaced with Ultra-High-Pressure Liquid Chromatography

(2010) Hui Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Alkyl Halides

(2010) Daniel A. Everson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A combinatorial approach to the identification of self-assembled ligands for rhodium-catalysed asymmetric hydrogenation

(2010) Joerg Wieland et al.   Nature Chemistry

Supramolecular catalysis beyond enzyme mimics

(2010) Jurjen Meeuwissen et al.   Nature Chemistry

Enantioselective Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of (E)-N-Phenylmethyleneglycine Ethyl Ester

(2010) Kevin M. Belyk et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Experimental design in chemistry: A tutorial

(2009) Riccardo Leardi   ANALYTICA CHIMICA ACTA

Application of a Supramolecular-Ligand Library for the Automated Search for Catalysts for the Asymmetric Hydrogenation of Industrially Relevant Substrates

(2009) Jurjen Meeuwissen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Combinations of Acidic and Basic Monodentate Binaphtholic Phosphites as Supramolecular Bidentate Ligands for Enantioselective Rh-Catalyzed Hydrogenations

(2009) Luca Pignataro et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

High-Throughput Experimentation Platform: Parallel Microwave Chemistry in HPLC/GC Vials

(2009) Markus Damm et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds

(2009) John R. Goodell et al.   JOURNAL OF ORGANIC CHEMISTRY

Combinatorial Transition-Metal Catalysis: Mixing Monodentate Ligands to Control Enantio-, Diastereo-, and Regioselectivity

(2008) Manfred T. Reetz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic effect of binary component ligands in chiral catalyst library engineering for enantioselective reactions

(2008) Kuiling Ding   CHEMICAL COMMUNICATIONS

Supramolecular Bidentate Ligands by Metal-Directed in situ Formation of Antiparallel β-Sheet Structures and Application in Asymmetric Catalysis

(2008) Andy C. Laungani et al.   CHEMISTRY-A EUROPEAN JOURNAL

Libraries of Bidentate Phosphorus Ligands; Synthesis Strategies and Application in Catalysis

(2008) P. Elsbeth Goudriaan et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Synthesis of Building Blocks for the Development of the SUPRAPhos Ligand Library and Examples of Their Application in Catalysis

(2008) P. Elsbeth Goudriaan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Efficient Cross-Coupling of Secondary Alkyltrifluoroborates with Aryl ChloridesReaction Discovery Using Parallel Microscale Experimentation

(2008) Spencer D. Dreher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA-Based Asymmetric Catalysis: Sequence-Dependent Rate Acceleration and Enantioselectivity

(2008) Arnold J. Boersma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Click-Connected Ligand Scaffolds:  Macrocyclic Chelates for Asymmetric Hydrogenation

(2008) Qing Zhang et al.   ORGANIC LETTERS

Solid-Phase Parallel Synthesis of Phosphite Ligands

(2008) Bert H. G. Swennenhuis et al.   ORGANIC LETTERS

Exploiting Self-Assembly for Ligand-Scaffold Optimization: Substrate-Tailored Ligands for Efficient Catalytic Asymmetric Hydroboration

(2007) Shin A. Moteki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Supramolecular PhanePhos-analogous ligands through hydrogen-bonding for asymmetric hydrogenation

(2007) Andy Ch. Laungani et al.   CHEMICAL COMMUNICATIONS