Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 8, Pages 3065-3071Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b12254
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- Natural Sciences and Engineering Research Council of Canada (NSERC)
- GreenCentre Canada
- University of Alberta
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High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized alpha-phenoxy and related amides at room temperature under 4 atm H-2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.
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