Structure and function of Zika virus NS5 protein: perspectives for drug design

Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond

(2017) Veaceslav Boldescu et al.   NATURE REVIEWS DRUG DISCOVERY

The uncoupling of catalysis and translocation in the viral RNA-dependent RNA polymerase

(2017) Bo Shu et al.   RNA Biology

Inhibitors compounds of the flavivirus replication process

(2017) Leidy L. García et al.   Virology Journal

The structure of Zika virus NS5 reveals a conserved domain conformation

(2017) Boxiao Wang et al.   Nature Communications

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

(2017) Andre S. Godoy et al.   Nature Communications

Structure and function of the Zika virus full-length NS5 protein

(2017) Baoyu Zhao et al.   Nature Communications

Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae

(2017) André C. Ferreira et al.   Scientific Reports

TAM Receptors Are Not Required for Zika Virus Infection in Mice

(2017) Andrew K. Hastings et al.   Cell Reports

Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses

(2017) Laurent Meertens et al.   Cell Reports

Zika virus genome biology and molecular pathogenesis

(2017) Anyou Wang et al.   Emerging Microbes & Infections

AXL is not essential for Zika virus infection in the mouse brain

(2017) Feng Li et al.   Emerging Microbes & Infections

Crystal structure of full-lengthZika virusNS5 protein reveals a conformation similar toJapanese encephalitis virusNS5

(2017) Anup K. Upadhyay et al.   Acta Crystallographica Section F-Structural Biology Communications

Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase

(2017) Rinku Jain et al.   Scientific Reports

Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus

(2016) Jie Qing et al.   ANTIVIRAL RESEARCH

Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus

(2016) Luděk Eyer et al.   ANTIVIRAL RESEARCH

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

(2016) Chao Shan et al.   Cell Host & Microbe

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

(2016) Tomasz J. Nowakowski et al.   Cell Stem Cell

Nucleoside Inhibitors of Zika Virus

(2016) Luděk Eyer et al.   JOURNAL OF INFECTIOUS DISEASES

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

(2016) Fumiaki Yokokawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

(2016) Bruno Coutard et al.   JOURNAL OF VIROLOGY

The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling

(2016) Sonja M. Best   JOURNAL OF VIROLOGY

Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study

(2016) Van-Mai Cao-Lormeau et al.   LANCET

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

Zika Virus and Birth Defects — Reviewing the Evidence for Causality

(2016) Sonja A. Rasmussen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus

(2016) Lyle R. Petersen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models

(2016) Rodrigo Delvecchio et al.   Viruses-Basel

Structures of NS5 Methyltransferase from Zika Virus

(2016) Javier Coloma et al.   Cell Reports

The IFITMs Inhibit Zika Virus Replication

(2016) George Savidis et al.   Cell Reports

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

(2016) Marco Onorati et al.   Cell Reports

The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model

(2016) Joanna Zmurko et al.   PLoS Neglected Tropical Diseases

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

(2016) Federico A. De Maio et al.   PLoS Pathogens

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

(2016) Siew Pheng Lim et al.   PLoS Pathogens

Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus

(2016) Yong-Qiang Deng et al.   Open Forum Infectious Diseases

Nucleoside Inhibitors of Tick-Borne Encephalitis Virus

(2015) Luděk Eyer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The dengue virus NS5 protein as a target for drug discovery

(2015) Siew Pheng Lim et al.   ANTIVIRAL RESEARCH

Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression

(2015) Kirk J. Lubick et al.   Cell Host & Microbe

Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases

(2015) Paolo Vincetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biology of Zika Virus Infection in Human Skin Cells

(2015) Rodolphe Hamel et al.   JOURNAL OF VIROLOGY

Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance

(2015) Auda Eltahla et al.   Viruses-Basel

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase

(2015) Matthew Brecher et al.   ACS Infectious Diseases

Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

(2014) Angela M. Lam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon

(2014) Maudry Laurent-Rolle et al.   Cell Host & Microbe

Sofosbuvir: First Global Approval

(2014) Gillian M. Keating et al.   DRUGS

Flavivirus RNA methylation

(2014) H. Dong et al.   JOURNAL OF GENERAL VIROLOGY

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

(2014) Supanee Potisopon et al.   NUCLEIC ACIDS RESEARCH

Regulation of Flavivirus RNA synthesis and replication

(2014) Barbara Selisko et al.   Current Opinion in Virology

In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues

(2013) Grégory Chatelain et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state

(2013) Parag Surana et al.   NUCLEIC ACIDS RESEARCH

Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling

(2013) Juliet Morrison et al.   PLoS Pathogens

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution

(2012) Cécile Bussetta et al.   BIOCHEMISTRY

Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

(2012) Barbara Selisko et al.   PLoS Pathogens

Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

(2011) Gang Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis

(2011) N. G. Iglesias et al.   JOURNAL OF VIROLOGY

Mouse STAT2 Restricts Early Dengue Virus Replication

(2010) Joseph Ashour et al.   Cell Host & Microbe

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

(2010) Eisuke Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase

(2010) Hongping Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

(2010) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

(2010) Michael J. Sofia et al.   JOURNAL OF MEDICINAL CHEMISTRY

The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling

(2010) M. Laurent-Rolle et al.   JOURNAL OF VIROLOGY

Molecular mechanisms involved in the early steps of flavivirus cell entry

(2010) Bärbel Kaufmann et al.   MICROBES AND INFECTION

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2′-O methyltransferase activity in dengue virus

(2010) Ka Yan Chung et al.   VIROLOGY

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

RNA-dependent RNA polymerases from Flaviviridae

(2009) Kyung H Choi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides 7MeGpppACn and GpppACn

(2009) B. Selisko et al.   JOURNAL OF GENERAL VIROLOGY

Dengue Virus NS5 Inhibits Interferon‐α Signaling by Blocking Signal Transducer and Activator of Transcription 2 Phosphorylation

(2009) Michela Mazzon et al.   JOURNAL OF INFECTIOUS DISEASES

Mechanisms of Evasion of the Type I Interferon Antiviral Response by Flaviviruses

(2009) Michael S. Diamond   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

(2009) J. Ashour et al.   JOURNAL OF VIROLOGY

Nucleic acid polymerases use a general acid for nucleotidyl transfer

(2009) Christian Castro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

(2009) M. Issur et al.   RNA

A scintillation proximity assay for dengue virus NS5 2′-O-methyltransferase—kinetic and inhibition analyses

(2008) S LIM et al.   ANTIVIRAL RESEARCH

The flavivirus polymerase as a target for drug discovery

(2008) Hélène Malet et al.   ANTIVIRAL RESEARCH