Interactions among myeloid regulatory cells in cancer

How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions

(2018) Annika M. Bruger et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Myeloid cell heterogeneity in cancer: not a single cell alike

(2018) Mate Kiss et al.   CELLULAR IMMUNOLOGY

Clinical relevance and suppressive capacity of human MDSC subsets

(2018) Stephan Lang et al.   CLINICAL CANCER RESEARCH

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

(2017) Ting-Ting Cai et al.   PLoS Pathogens

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity

(2017) Louise A. Elliott et al.   Frontiers in Immunology

TIE-2 expressing monocytes in human cancers

(2017) Riccardo Turrini et al.   OncoImmunology

The Ontogeny and Microenvironmental Regulation of Tumor-Associated Macrophages

(2016) Kiavash Movahedi et al.   ANTIOXIDANTS & REDOX SIGNALING

Clinical Significance of Circulating CD33+CD11b+HLA-DR- Myeloid Cells in Patients with Stage IV Melanoma Treated with Ipilimumab

(2016) M. Sade-Feldman et al.   CLINICAL CANCER RESEARCH

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

(2016) Vinit Kumar et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Human neutrophils in the saga of cellular heterogeneity: insights and open questions

(2016) Patrizia Scapini et al.   IMMUNOLOGICAL REVIEWS

CD163 + M2-type tumor-associated macrophage support the suppression of tumor-infiltrating T cells in osteosarcoma

(2016) Qinglin Han et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Growing tumors induce a local STING dependent Type I IFN response in dendritic cells

(2016) Lisa Andzinski et al.   INTERNATIONAL JOURNAL OF CANCER

Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer

(2016) Maria Rosaria Galdiero et al.   INTERNATIONAL JOURNAL OF CANCER

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

(2016) Sebastian R. Nielsen et al.   NATURE CELL BIOLOGY

Myeloid-Derived Suppressor Cells in Cancers and Inflammatory Diseases: Angel or Demon?

(2016) Z. Su et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells

(2016) Katrin Moses et al.   SEMINARS IN IMMUNOLOGY

Myeloid-derived suppressor cells and tumor escape from immune surveillance

(2016) Viktor Umansky et al.   Seminars in Immunopathology

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

(2016) Damya Laoui et al.   Nature Communications

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

(2016) Robert L. Bowman et al.   Cell Reports

The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression

(2015) Chang-Ni Lin et al.   BMC CANCER

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis

(2015) Laura Strauss et al.   CANCER CELL

Myeloid-derived suppressor cells inhibit T cell proliferation in human extranodal NK/T cell lymphoma: a novel prognostic indicator

(2015) Han Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

(2015) E. Van Overmeire et al.   CANCER RESEARCH

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab

(2015) C. Gebhardt et al.   CLINICAL CANCER RESEARCH

Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy

(2015) Giuseppe Di Caro et al.   GUT

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung

(2015) Ching-Fang Wu et al.   INTERNATIONAL JOURNAL OF CANCER

Type IIFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human

(2015) Lisa Andzinski et al.   INTERNATIONAL JOURNAL OF CANCER

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis

(2015) Bin-Zhi Qian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The interaction of anticancer therapies with tumor-associated macrophages

(2015) Alberto Mantovani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Functions of Neutrophil in Cancer and Its Regulation

(2015) Zvi Granot et al.   MEDIATORS OF INFLAMMATION

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling

(2015) Michael Tang et al.   Cell Reports

Arming the Melanoma Sentinel Lymph Node through Local Administration of CpG-B and GM-CSF: Recruitment and Activation of BDCA3/CD141 + Dendritic Cells and Enhanced Cross-Presentation

(2015) Berbel J.R. Sluijter et al.   Cancer Immunology Research

How Neutrophils Shape Adaptive Immune Responses

(2015) Pieter H. C. Leliefeld et al.   Frontiers in Immunology

Prognostic Value of Tumor-Associated Macrophages According to Histologic Locations and Hormone Receptor Status in Breast Cancer

(2015) Jae Moon Gwak et al.   PLoS One

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

Circulating myeloid-derived suppressor cells correlate with clinical outcome in Hodgkin Lymphoma patients treated up-front with a risk-adapted strategy

(2014) Alessandra Romano et al.   BRITISH JOURNAL OF HAEMATOLOGY

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

The immune contexture of primary and metastatic human tumours

(2014) Nicolas A Giraldo et al.   CURRENT OPINION IN IMMUNOLOGY

In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors

(2014) Piotr Tymoszuk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients

(2014) Huanhuan Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGF -1

(2014) N. D. L. Savage et al.   JOURNAL OF IMMUNOLOGY

Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer

(2014) W. Cao et al.   JOURNAL OF IMMUNOLOGY

Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors

(2014) Daniel W. Beury et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis

(2014) Arnoud J. Templeton et al.   JNCI-Journal of the National Cancer Institute

Epstein-Barr Virus Infection Induces Indoleamine 2,3-Dioxygenase Expression in Human Monocyte-Derived Macrophages through p38/Mitogen-Activated Protein Kinase and NF- B Pathways: Impairment in T Cell Functions

(2014) W.-l. Liu et al.   JOURNAL OF VIROLOGY

The targeting of immunosuppressive mechanisms in hematological malignancies

(2014) M H Andersen   LEUKEMIA

Prognostic impact of preoperative monocyte counts in patients with resected lung adenocarcinoma

(2014) Shogo Kumagai et al.   LUNG CANCER

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Tumor-Associated Neutrophils as a New Prognostic Factor in Cancer: A Systematic Review and Meta-Analysis

(2014) Meixiao Shen et al.   PLoS One

Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes

(2014) F. H. W. Shand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils mediate antibody-induced antitumor effects in mice

(2013) M. Albanesi et al.   BLOOD

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients

(2013) Kimberly R. Jordan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD68+HLA-DR+ M1-like macrophages promote motility of HCC cells via NF-κB/FAK pathway

(2013) Hao Wang et al.   CANCER LETTERS

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Predict Survival of Patients with Advanced Melanoma: Comparison with Regulatory T Cells and NY-ESO-1- or Melan-A-Specific T Cells

(2013) B. Weide et al.   CLINICAL CANCER RESEARCH

CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-β

(2013) J. Jablonska et al.   INTERNATIONAL JOURNAL OF CANCER

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling

(2013) Nataša Obermajer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The metastasis-promoting roles of tumor-associated immune cells

(2013) Heath A. Smith et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Circulating and Tumor-Infiltrating Myeloid-Derived Suppressor Cells in Patients with Colorectal Carcinoma

(2013) Bin Zhang et al.   PLoS One

Neutrophils as effector cells for antibody-based immunotherapy of cancer

(2013) Marjolein van Egmond et al.   SEMINARS IN CANCER BIOLOGY

The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: Cousins, siblings or twins?

(2013) Sven Brandau et al.   SEMINARS IN CANCER BIOLOGY

Dendritic Cells in the Cancer Microenvironment

(2013) Yang Ma et al.   Journal of Cancer

Ipilimumab Treatment Results in an Early Decrease in the Frequency of Circulating Granulocytic Myeloid-Derived Suppressor Cells as well as Their Arginase1 Production

(2013) Y. P. de Coana et al.   Cancer Immunology Research

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

On the armament and appearances of human myeloid-derived suppressor cells

(2012) Isabel Poschke et al.   CLINICAL IMMUNOLOGY

Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression

(2012) M A López-Lago et al.   ONCOGENE

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into chronic inflammation-induced immunosuppression

(2012) Julia Kanterman et al.   SEMINARS IN CANCER BIOLOGY

Protumor and antitumor functions of neutrophil granulocytes

(2012) Sven Brandau et al.   Seminars in Immunopathology

Tumor conditioned media from colorectal cancer patients inhibits dendritic cell maturation

(2012) Adriana J. Michielsen et al.   OncoImmunology

Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma

(2011) Dirk Bausch et al.   ANGIOGENESIS

A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells

(2011) S. Solito et al.   BLOOD

Predictive clinical outcome of the intratumoral CD66b-positive neutrophil-to-CD8-positive T-cell ratio in patients with resectable nonsmall cell lung cancer

(2011) Marius Ilie et al.   CANCER

Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma

(2011) Trine O. Jensen et al.   CANCER

Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

(2011) Qing Chen et al.   CANCER CELL

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines

(2011) I. Poschke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients

(2011) Paola Filipazzi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Overcoming immunosuppression in the melanoma microenvironment induced by chronic inflammation

(2011) Viktor Umansky et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

(2011) T. R. Sippel et al.   CLINICAL CANCER RESEARCH

CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2011) C. Zoglmeier et al.   CLINICAL CANCER RESEARCH

Peripheral blood lymphocyte/monocyte ratio at diagnosis and survival in classical Hodgkin's lymphoma

(2011) L. F. Porrata et al.   HAEMATOLOGICA

The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis

(2011) Catherine E. Steding et al.   IMMUNOLOGY

Tumor-derived macrophage migration inhibitory factor modulates the biology of head and neck cancer cells via neutrophil activation

(2011) Claudia A. Dumitru et al.   INTERNATIONAL JOURNAL OF CANCER

CD15+/CD16low human granulocytes from terminal cancer patients: granulocytic myeloid-derived suppressor cells that have suppressive function

(2011) Jahyang Choi et al.   TUMOR BIOLOGY

TGF-  Receptor II Loss Promotes Mammary Carcinoma Progression by Th17-Dependent Mechanisms

(2011) S. V. Novitskiy et al.   Cancer Discovery

Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

(2011) Benjamin Toh et al.   PLOS BIOLOGY

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Targeting immune suppressing myeloid-derived suppressor cells in oncology

(2010) Johnny Kao et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Understanding the molecular mechanisms of the multifaceted IL-10-mediated anti-inflammatory response: Lessons from neutrophils

(2010) Flavia Bazzoni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model

(2010) Jadwiga Jablonska et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The expanding family of dendritic cell subsets

(2010) Hideki Ueno et al.   NATURE BIOTECHNOLOGY

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Up-regulated myeloid-derived suppressor cell contributes to hepatocellular carcinoma development by impairing dendritic cell function

(2010) Cheng-En Hu et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Type I interferons inhibit the generation of tumor-associated macrophages

(2009) Lance U’Ren et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer

(2009) P.-Y. Pan et al.   CANCER RESEARCH

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor

(2009) Bastian Hoechst et al.   HEPATOLOGY

Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma

(2009) Hanne Krogh Jensen et al.   JOURNAL OF CLINICAL ONCOLOGY

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

The role of chemokines in neutrophil biology

(2007) Yoshiro Kobayashi   Frontiers in Bioscience-Landmark