Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

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Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif

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α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA B receptors

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Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

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Experimental design and analysis and their reporting: new guidance for publication in BJP

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Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

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Irritable Bowel Syndrome

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Activation of GABAB receptors potentiates inward rectifying potassium currents in satellite glial cells from rat trigeminal ganglia: In vivo patch-clamp analysis

(2015) M. Takeda et al.   NEUROSCIENCE

Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1

(2015) Rilei Yu et al.   Scientific Reports

Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?

(2015) Sarasa Mohammadi et al.   Toxins

Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity

(2014) Annemie Deiteren et al.   GUT

Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABABreceptor activation

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Neuroplasticity and dysfunction after gastrointestinal inflammation

(2014) Stuart M. Brierley et al.   Nature Reviews Gastroenterology & Hepatology

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

(2014) Aline Dantas de Araujo et al.   Nature Communications

Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels

(2013) David J. Adams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

(2013) Joel Castro et al.   GASTROENTEROLOGY

Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity

(2013) Patrick A Hughes et al.   GUT

Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor

(2013) Rilei Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

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Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)

(2012) Irina Vetter et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Therapeutic potential of conopeptides

(2012) Christina I Schroeder et al.   Future Medicinal Chemistry

Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes

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Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity

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Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels

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TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity

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The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

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Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice

(2010) Brid Callaghan et al.   Channels

A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain

(2010) Harry Klimis et al.   PAIN

Visceral afferents — Determinants and modulation of excitability

(2009) Michael J. Beyak   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Alpha9 nicotinic acetylcholine receptors and the treatment of pain

(2009) J. Michael McIntosh et al.   BIOCHEMICAL PHARMACOLOGY

Structure of the Analgesic μ-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion†‡

(2009) Keith K. Khoo et al.   BIOCHEMISTRY

Post-inflammatory modification of colonic afferent mechanosensitivity

(2009) PA Hughes et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli

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Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses

(2009) P A Hughes et al.   GUT

Selective Role for TRPV4 Ion Channels in Visceral Sensory Pathways

(2008) Stuart M. Brierley et al.   GASTROENTEROLOGY

Analgesic  -Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation

(2008) B. Callaghan et al.   JOURNAL OF NEUROSCIENCE