Antinociception by the anti-oxidized phospholipid antibody E06

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

(2017) Gregory Corder et al.   NATURE MEDICINE

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Muscle Reactive Oxygen Species (ROS) Contribute to Post-Incisional Guarding via the TRPA1 Receptor

(2017) Daisuke Sugiyama et al.   PLoS One

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

(2017) Francesco De Logu et al.   Nature Communications

Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation

(2017) Beatrice Oehler et al.   Scientific Reports

TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization

(2017) Olivier Gouin et al.   Protein & Cell

Transient Receptor Potential Ankyrin 1 Channel Expression on Peripheral Blood Leukocytes from Rheumatoid Arthritic Patients and Correlation with Pain and Disability

(2017) Ione Pereira et al.   Frontiers in Pharmacology

Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction

(2016) Daniel J. DelloStritto et al.   BASIC RESEARCH IN CARDIOLOGY

TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress

(2016) Gabriela Trevisan et al.   BRAIN

What is the evidence for the role of TRP channels in inflammatory and immune cells?

(2016) A Parenti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sensing of redox status by TRP channels

(2016) Nozomi Ogawa et al.   CELL CALCIUM

Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids

(2016) S. Marra et al.   EMBO JOURNAL

Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation

(2016) Jin-Feng Zhao et al.   International Journal of Biological Sciences

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD

(2016) Arnab Chattopadhyay et al.   JOURNAL OF LIPID RESEARCH

TRPA1 channels: molecular sentinels of cellular stress and tissue damage

(2016) Félix Viana   JOURNAL OF PHYSIOLOGY-LONDON

The TRPM2 ion channel is required for sensitivity to warmth

(2016) Chun-Hsiang Tan et al.   NATURE

Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice

(2016) Boyi Liu et al.   PLoS One

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

(2016) Takahito Miyake et al.   Nature Communications

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular sensors and modulators of thermoreception

(2015) Xuming Zhang   Channels

Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study

(2015) Marcelo E Bigal et al.   LANCET NEUROLOGY

Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study

(2015) Marcelo E Bigal et al.   LANCET NEUROLOGY

Crosstalk between the nociceptive and immune systems in host defence and disease

(2015) Stephen B. McMahon et al.   NATURE REVIEWS NEUROSCIENCE

The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia

(2015) M.-K. Chung et al.   NEUROSCIENCE

Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals

(2015) Éva Sághy et al.   PHARMACOLOGICAL RESEARCH

CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine

(2015) Jacob D. Brown et al.   Science Translational Medicine

Studying ongoing and spontaneous pain in rodents - challenges and opportunities

(2014) Anke Tappe-Theodor et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Release and Capture of Bioactive Oxidized Phospholipids and Oxidized Cholesteryl Esters During Percutaneous Coronary and Peripheral Arterial Interventions in Humans

(2014) Amir Ravandi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fasinumab (REGN475), an antibody against nerve growth factor for the treatment of pain: Results from a double-blind, placebo-controlled exploratory study in osteoarthritis of the knee

(2014) Paul J. Tiseo et al.   PAIN

Nociception and inflammatory hyperalgesia evaluated in rodents using infrared laser stimulation after Trpv1 gene knockout or resiniferatoxin lesion

(2014) Kendall Mitchell et al.   PAIN

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Transient Receptor Potential Ankyrin 1 Receptor Stimulation by Hydrogen Peroxide Is Critical to Trigger Pain During Monosodium Urate-Induced Inflammation in Rodents

(2013) Gabriela Trevisan et al.   ARTHRITIS AND RHEUMATISM

TRPA1: A Transducer and Amplifier of Pain and Inflammation

(2013) Ari Koivisto et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

(2013) B Romano et al.   BRITISH JOURNAL OF PHARMACOLOGY

4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases

(2013) Mohammad Shoeb et al.   CURRENT MEDICINAL CHEMISTRY

WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs

(2013) Ulrich Matt et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Cholesterol Depletion on the Pore Dilation of TRPV1

(2013) Erik T Jansson et al.   Molecular Pain

Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain

(2013) Alan J. Kivitz et al.   PAIN

Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke

(2012) Rajesh K. Thimmulappa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein modification by aldehydophospholipids and its functional consequences

(2012) Ute Stemmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Transient opening of the perineurial barrier for analgesic drug delivery

(2012) D. Hackel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Oxidized Phospholipids by MALDI Mass Spectrometry Using 6-Aza-2-thiothymine Together with Matrix Additives and Disposable Target Surfaces

(2010) Gerald Stübiger et al.   ANALYTICAL CHEMISTRY

Short-Term Stimulation of Calcium-Permeable Transient Receptor Potential Canonical 5–Containing Channels by Oxidized Phospholipids

(2010) Eman AL-Shawaf et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPC5 Channel Sensitivities to Antioxidants and Hydroxylated Stilbenes

(2010) Jacqueline Naylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents

(2010) Amol M. Patwardhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidized Phospholipids Are More Potent Antagonists of Lipopolysaccharide than Inducers of Inflammation

(2010) O. V. Oskolkova et al.   JOURNAL OF IMMUNOLOGY

Roles of transient receptor potential channels in pain

(2009) Cheryl L. Stucky et al.   BRAIN RESEARCH REVIEWS

Regulation of Dendritic Cells and Macrophages by an Anti-Apoptotic Cell Natural Antibody that Suppresses TLR Responses and Inhibits Inflammatory Arthritis

(2009) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Mycobacteria Attenuate Nociceptive Responses by Formyl Peptide Receptor Triggered Opioid Peptide Release from Neutrophils

(2009) Heike L. Rittner et al.   PLoS Pathogens

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Targeted Molecular Probes for Imaging Atherosclerotic Lesions With Magnetic Resonance Using Antibodies That Recognize Oxidation-Specific Epitopes

(2008) Karen C. Briley-Saebo et al.   CIRCULATION

Activation of transient receptor potential ankyrin 1 by hydrogen peroxide

(2008) Yosuke Sawada et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms

(2008) Julie Elizabeth Keeble et al.   PAIN