What is the evidence for the role of TRP channels in inflammatory and immune cells?

The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages

(2014) Sumeet Solanki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Transient Receptor Potential Melastatin 2 Protects Mice against Polymicrobial Sepsis by Enhancing Bacterial Clearance

(2014) XiaoWei Qian et al.   ANESTHESIOLOGY

Transient receptor potential cation channels in visceral sensory pathways

(2014) L Ashley Blackshaw   BRITISH JOURNAL OF PHARMACOLOGY

TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions

(2014) Katherine Brandao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout

(2014) Gabriela Trevisan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of TRPM7 Channels Reduces Degranulation and Release of Cytokines in Rat Bone Marrow-Derived Mast Cells

(2014) Linjie Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Secretogranin III Directs Secretory Vesicle Biogenesis in Mast Cells in a Manner Dependent upon Interaction with Chromogranin A

(2014) P. Prasad et al.   JOURNAL OF IMMUNOLOGY

Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line

(2014) H.-T. Ma et al.   JOURNAL OF IMMUNOLOGY

Ion Channels Modulating Mouse Dendritic Cell Functions

(2014) N. Matzner et al.   JOURNAL OF IMMUNOLOGY

TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected withPlasmodium bergheiANKA

(2014) Elizabeth S. Fernandes et al.   MEDIATORS OF INFLAMMATION

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells

(2014) Samuel Bertin et al.   NATURE IMMUNOLOGY

Modulation of oxidative stress, apoptosis, and calcium entry in leukocytes of patients with multiple sclerosis byHypericum perforatum

(2014) Mustafa Naziroglu et al.   NUTRITIONAL NEUROSCIENCE

Upregulation of the Transient Receptor Potential Ankyrin 1 Ion Channel in the Inflamed Human and Mouse Colon and Its Protective Roles

(2014) József Kun et al.   PLoS One

The Transient Receptor Potential Vanilloid 2 Cation Channel Is Abundant in Macrophages Accumulating at the Peri-Infarct Zone and May Enhance Their Migration Capacity towards Injured Cardiomyocytes following Myocardial Infarction

(2014) Michal Entin-Meer et al.   PLoS One

TRPM2 channels mediate acetaminophen-induced liver damage

(2014) E. Kheradpezhouh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Receptor Potential Melastatin Subfamily Member 2 Cation Channel Regulates Detrimental Immune Cell Invasion in Ischemic Stroke

(2014) Mathias Gelderblom et al.   STROKE

Inactivation of TRPM7 kinase activity does not impair its channel function in mice

(2014) Taku Kaitsuka et al.   Scientific Reports

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

(2014) Guillermo Arango Duque et al.   Frontiers in Immunology

Transient Receptor Potential Ion Channels

(2013) Adrian T. Billeter et al.   ANNALS OF SURGERY

Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain

(2013) S Kelly et al.   ANNALS OF THE RHEUMATIC DISEASES

Transient Receptor Potential Ankyrin 1 Receptor Stimulation by Hydrogen Peroxide Is Critical to Trigger Pain During Monosodium Urate-Induced Inflammation in Rodents

(2013) Gabriela Trevisan et al.   ARTHRITIS AND RHEUMATISM

Ca2+ dynamics correlates with phenotype and function in primary human neutrophils

(2013) Katrin Hübner et al.   BIOPHYSICAL CHEMISTRY

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

(2013) B Romano et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient receptor potential (TRP) channels in the airway: role in airway disease

(2013) M S Grace et al.   BRITISH JOURNAL OF PHARMACOLOGY

New insights into pharmacological tools to TR(i)P cancer up

(2013) M Gautier et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRP channels in the skin

(2013) Balázs I Tóth et al.   BRITISH JOURNAL OF PHARMACOLOGY

The TRPA1 channel in migraine mechanism and treatment

(2013) S Benemei et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRP channels in lower urinary tract dysfunction

(2013) J Franken et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bone marrow deficiency of TRPC3 channel reduces early lesion burden and necrotic core of advanced plaques in a mouse model of atherosclerosis

(2013) Jean-Yves Tano et al.   CARDIOVASCULAR RESEARCH

Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production

(2013) Nevenka Medic et al.   CELL CALCIUM

Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells

(2013) Attila Gábor Szöllősi et al.   FEBS LETTERS

TRPC6 Regulates CXCR2-Mediated Chemotaxis of Murine Neutrophils

(2013) O. Lindemann et al.   JOURNAL OF IMMUNOLOGY

TRPV1 and TRPA1 Antagonists Prevent the Transition of Acute to Chronic Inflammation and Pain in Chronic Pancreatitis

(2013) E. S. Schwartz et al.   JOURNAL OF NEUROSCIENCE

TRPV3: time to decipher a poorly understood family member!

(2013) Bernd Nilius et al.   JOURNAL OF PHYSIOLOGY-LONDON

Unknown

(2013) Geoffrey Paltser et al.   MOLECULAR MEDICINE

Neurological and cellular regulation of visceral hypersensitivity induced by chronic stress and colonic inflammation in rats

(2013) J. Chen et al.   NEUROSCIENCE

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

TRPM2 contributes to antigen-stimulated Ca2+ influx in mucosal mast cells

(2013) Satoshi Oda et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Orai-1 and STIM-1 Complex Controls Human Dendritic Cell Maturation

(2013) Romain Félix et al.   PLoS One

TRPM8 activation attenuates inflammatory responses in mouse models of colitis

(2013) R. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Cells: Master Regulators of the Immune Response

(2013) I. Mellman   Cancer Immunology Research

The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses

(2013) Giorgio Santoni et al.   Frontiers in Immunology

Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofin

(2012) Noriyuki Hatano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine

(2012) Toru Kono et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in Mice

(2012) Valérie Hox et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice

(2012) Angelo A Izzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient Receptor Potentials (TRPs) and Anaphylaxis

(2012) Peter K. Smith et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Cleavage of TRPM7 Releases the Kinase Domain from the Ion Channel and Regulates Its Participation in Fas-Induced Apoptosis

(2012) Bimal N. Desai et al.   DEVELOPMENTAL CELL

TRP channels as therapeutic targets in airway disorders: a patent review

(2012) Delia Preti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The role of Mg2+ in immune cells

(2012) Katherine Brandao et al.   IMMUNOLOGIC RESEARCH

The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation

(2012) Heather Knowles et al.   IMMUNOLOGIC RESEARCH

NAD+Levels Control Ca2+Store Replenishment and Mitogen-induced Increase of Cytosolic Ca2+by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes

(2012) Mirko Magnone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TRPM4 Channel Controls Monocyte and Macrophage, but Not Neutrophil, Function for Survival in Sepsis

(2012) N. Serafini et al.   JOURNAL OF IMMUNOLOGY

TRPV1 Deletion Enhances Local Inflammation and Accelerates the Onset of Systemic Inflammatory Response Syndrome

(2012) E. S. Fernandes et al.   JOURNAL OF IMMUNOLOGY

Expression of Transient Receptor Potential Vanilloid Channels TRPV5 and TRPV6 in Human Blood Lymphocytes and Jurkat Leukemia T Cells

(2012) Irina O. Vassilieva et al.   JOURNAL OF MEMBRANE BIOLOGY

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

(2012) Benjamin Schattling et al.   NATURE MEDICINE

Transient Receptor Potential Vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment?

(2012) J. Fichna et al.   NEUROGASTROENTEROLOGY AND MOTILITY

TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation

(2012) Nico Melzer et al.   PLoS One

Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions

(2012) M. Kashio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient receptor potential ankyrin 1 activation enhances hapten sensitization in a T-helper type 2-driven fluorescein isothiocyanate-induced contact hypersensitivity mouse model

(2012) Takahiro Shiba et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Role of TRP Proteins in Mast Cells

(2012) Marc Freichel et al.   Frontiers in Immunology

Roles for Ca2+ Mobilization and Its Regulation in Mast Cell Functions

(2012) David Holowka et al.   Frontiers in Immunology

Ca2+ signaling in the regulation of dendritic cell functions

(2011) Ekaterina Shumilina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Disruption of the Transient Receptor Potential Vanilloid 1 Can Affect Survival, Bacterial Clearance, and Cytokine Gene Expression during Murine Sepsis

(2011) Virginia Guptill et al.   ANESTHESIOLOGY

Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages

(2011) Jean-Yves Tano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRP expression pattern and the functional importance of TRPC3 in primary human T-cells

(2011) Anna S. Wenning et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria

(2011) Nevenka Medic et al.   CELL CALCIUM

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release

(2011) Adriana Sumoza-Toledo et al.   FASEB JOURNAL

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons

(2011) Matthias A. Engel et al.   JOURNAL OF GASTROENTEROLOGY

An Essential Role of STIM1, Orai1, and S100A8-A9 Proteins for Ca2+ Signaling and Fc R-Mediated Phagosomal Oxidative Activity

(2011) N. Steinckwich et al.   JOURNAL OF IMMUNOLOGY

Characterization of TRPM8-Like Channels Activated by the Cooling Agent Icilin in the Macrophage Cell Line RAW 264.7

(2011) Sheng-Nan Wu et al.   JOURNAL OF MEMBRANE BIOLOGY

Functional Expression of TRPV4 Cation Channels in Human Mast Cell Line (HMC-1)

(2011) Kyung Soo Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

(2011) Anke Di et al.   NATURE IMMUNOLOGY

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-α and of IL-1β in experimental autoimmune encephalomyelitis

(2011) Gabriele Musumeci et al.   NEUROBIOLOGY OF DISEASE

A novel role for TRPM8 in visceral afferent function

(2011) Andrea M. Harrington et al.   PAIN

Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system

(2011) Peter Holzer   PHARMACOLOGY & THERAPEUTICS

Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes

(2011) H. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfur mustard primes human neutrophils for increased degranulation and stimulates cytokine release via TRPM2/p38 MAPK signaling

(2011) Hwa-Yong Ham et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages

(2010) Kenji Yamashiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRPM8 mediates cold and menthol allergies associated with mast cell activation

(2010) Yeongyo Cho et al.   CELL CALCIUM

Transient Receptor Potential Vanilloid 4 Activated Inflammatory Signals by Intestinal Epithelial Cells and Colitis in Mice

(2010) Emilie D'Aldebert et al.   GASTROENTEROLOGY

Pharmacology of receptor operated calcium entry in human neutrophils

(2010) Michael D. Salmon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ca 2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells

(2010) Takuro Numaga et al.   JOURNAL OF CELL SCIENCE

Lysophosphatidylcholine Increases Neutrophil Bactericidal Activity by Enhancement of Azurophil Granule-Phagosome Fusion via Glycine{middle dot}GlyR 2/TRPM2/p38 MAPK Signaling

(2010) C. W. Hong et al.   JOURNAL OF IMMUNOLOGY

Trpm4 Differentially Regulates Th1 and Th2 Function by Altering Calcium Signaling and NFAT Localization

(2010) K. S. Weber et al.   JOURNAL OF IMMUNOLOGY

Transient Receptor Potential Melastatin 2 Is Required for Lipopolysaccharide-Induced Cytokine Production in Human Monocytes

(2010) Janine Wehrhahn et al.   JOURNAL OF IMMUNOLOGY

Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells

(2010) Ryo Suzuki et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification

(2010) John G. Starkus et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

(2010) Tiffany M Link et al.   NATURE IMMUNOLOGY

Expression of Transient Receptor Potential C6 Channels in Human Lung Macrophages

(2009) Tricia K. Finney-Hayward et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Physiology and pathophysiology of canonical transient receptor potential channels

(2009) Joel Abramowitz et al.   FASEB JOURNAL

Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells

(2009) Balázs I. Tóth et al.   FEBS LETTERS

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Mechanism and Regulatory Function of CpG Signaling via Scavenger Receptor B1 in Primary B Cells

(2009) Peimin Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Native Store-operated Ca2+Influx Requires the Channel Function of Orai1 and TRPC1

(2009) Min Seuk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

A Transient Receptor Potential-Like Channel Mediates Synaptic Transmission in Rod Bipolar Cells

(2009) Y. Shen et al.   JOURNAL OF NEUROSCIENCE

Protein Profiling of Plasma Membranes Defines Aberrant Signaling Pathways in Mantle Cell Lymphoma

(2009) Robert S. Boyd et al.   MOLECULAR & CELLULAR PROTEOMICS

Tumor Necrosis Factor-Alpha (TNF-α) Enhances Functional Thermal and Chemical Responses of TRP Cation Channels in Human Synoviocytes

(2009) Mikhail Y Kochukov et al.   Molecular Pain

Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes

(2009) Elena Pantaler et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

(2009) A. I. Caceres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM1 Forms Ion Channels Associated with Melanin Content in Melanocytes

(2009) E. Oancea et al.   Science Signaling

The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils

(2008) N. Damann et al.   Acta Physiologica

The concept of neurogenic inflammation

(2008) Pierangelo Geppetti et al.   BJU INTERNATIONAL

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils

(2008) Ingo Lange et al.   CELL CALCIUM

Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes

(2008) S. Bréchard et al.   CELL CALCIUM

TRPM4 regulates migration of mast cells in mice

(2008) Takahiro Shimizu et al.   CELL CALCIUM

Calcium signaling in lymphocytes

(2008) Masatsugu Oh-hora et al.   CURRENT OPINION IN IMMUNOLOGY

The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes

(2008) Ben Buelow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytes

(2008) K. Gavenis et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TRPC channel activation by extracellular thioredoxin

(2008) Shang-Zhong Xu et al.   NATURE

The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells

(2008) Gaëtan Barbet et al.   NATURE IMMUNOLOGY

Calcium signaling in immune cells

(2008) Monika Vig et al.   NATURE IMMUNOLOGY

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation

(2008) M. I. Lioudyno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis

(2008) J. Jin et al.   SCIENCE