LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway

Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness

(2017) Joshua C. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IQGAP1 Interaction with RHO Family Proteins Revisited

(2016) Kazem Nouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LGR5-Targeted Antibody–Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence

(2016) Xing Gong et al.   MOLECULAR CANCER THERAPEUTICS

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics

(2015) Takashi Watanabe et al.   CELL STRUCTURE AND FUNCTION

Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions

(2015) J. C. Snyder et al.   JOURNAL OF CELL SCIENCE

Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3

(2015) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

ZNRF3/RNF43 – A direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling

(2015) Matthias Zebisch et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

IQGAPs choreograph cellular signaling from the membrane to the nucleus

(2015) Jessica M. Smith et al.   TRENDS IN CELL BIOLOGY

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

(2014) Bernd Kinzel et al.   DEVELOPMENTAL BIOLOGY

Stem Cells Marked by the R-Spondin Receptor LGR5

(2014) Bon-Kyoung Koo et al.   GASTROENTEROLOGY

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

(2014) Laila Ritsma et al.   NATURE

Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness

(2014) X Gong et al.   ONCOGENE

RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

(2014) Kendra S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis of R-spondin recognition by LGR5 and RNF43

(2013) P.-H. Chen et al.   GENES & DEVELOPMENT

Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

(2013) Joshua C. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway

(2013) Mi So Kwon et al.   MOLECULES AND CELLS

Rho family GTPases

(2012) Alan Hall   BIOCHEMICAL SOCIETY TRANSACTIONS

Cadherin junctions and their cytoskeleton(s)

(2012) William M Brieher et al.   CURRENT OPINION IN CELL BIOLOGY

Functions of BMP signaling in embryonic stem cell fate determination

(2012) Zhongwei Li et al.   EXPERIMENTAL CELL RESEARCH

LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/ -Catenin Signaling

(2012) K. S. Carmon et al.   MOLECULAR AND CELLULAR BIOLOGY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

LGR6 Is a High Affinity Receptor of R-Spondins and Potentially Functions as a Tumor Suppressor

(2012) Xing Gong et al.   PLoS One

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

(2012) Heinz Ruffner et al.   PLoS One

IQGAP1 and its binding proteins control diverse biological functions

(2011) Colin D. White et al.   CELLULAR SIGNALLING

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

(2011) Roxana C Mustata et al.   EMBO REPORTS

MAPK Scaffold IQGAP1 Binds the EGF Receptor and Modulates Its Activation

(2011) Dean E. McNulty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

LGR5 Is a Negative Regulator of Tumourigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines

(2011) Francesca Walker et al.   PLoS One

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

(2010) Nick Barker et al.   GASTROENTEROLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

(2009) Bettye Hollins et al.   CELLULAR SIGNALLING

IQGAP1 regulation and roles in cancer

(2009) Michael Johnson et al.   CELLULAR SIGNALLING

LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine

(2009) Marie Isabelle Garcia et al.   DEVELOPMENTAL BIOLOGY

Quantification of Gi-Mediated Inhibition of Adenylyl Cyclase Activity Reveals That UDP Is a Potent Agonist of the Human P2Y14 Receptor

(2009) R. L. Carter et al.   MOLECULAR PHARMACOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

hGPR87 contributes to viability of human tumor cells

(2008) Sebastian Glatt et al.   INTERNATIONAL JOURNAL OF CANCER

Orphan G Protein-coupled Receptor GPR56 Regulates Neural Progenitor Cell Migration via a Gα12/13 and Rho Pathway

(2008) Tokuichi Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY