Aberrant regulation of autophagy in mammalian diseases

Regulation of autophagy factors by oxidative stress and cardiac enzymes imbalance during arsenic or/and copper induced cardiotoxicity in Gallus gallus

(2018) Siwen Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Use of animal models for the imaging and quantification of angiogenesis

(2018) Min Liu et al.   EXPERIMENTAL ANIMALS

Non-mammalian Toll-like receptor 18 (Tlr18) recognizes bacterial pathogens in common carp ( Cyprinus carpio L.): Indications for a role of participation in the NF-κB signaling pathway

(2018) Shijuan Shan et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular characterization and expression pattern of X box-binding protein-1 (XBP1) in common carp ( Cyprinus carpio L.): Indications for a role of XBP1 in antibacterial and antiviral immunity

(2017) Ting Li et al.   FISH & SHELLFISH IMMUNOLOGY

Pathogen invasion changes the intestinal microbiota composition and induces innate immune responses in the zebrafish intestine

(2017) Hui-Ting Yang et al.   FISH & SHELLFISH IMMUNOLOGY

Oogenesis, vitellogenin-mediated ovarian degeneration and immune response in the annual fish Nothobranchius guentheri

(2017) Tingting Liu et al.   FISH & SHELLFISH IMMUNOLOGY

ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis

(2017) Abdo Mahli et al.   GUT

Regulation of mitotic spindle orientation during epidermal stratification

(2017) Wei Xie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The tumor suppressor CYLD controls epithelial morphogenesis and homeostasis by regulating mitotic spindle behavior and adherens junction assembly

(2017) Wei Xie et al.   Journal of Genetics and Genomics

Chloroquine and hydroxychloroquine inhibit bladder cancer cell growth by targeting basal autophagy and enhancing apoptosis

(2017) Yi-Chia Lin et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Overexpression of Populus tomentosa cytosolic ascorbate peroxidase enhances abiotic stress tolerance in tobacco plants

(2017) S. Cao et al.   RUSSIAN JOURNAL OF PLANT PHYSIOLOGY

A switch from canonical to noncanonical autophagy shapes B cell responses

(2017) Nuria Martinez-Martin et al.   SCIENCE

Role of autophagy in Zika virus infection and pathogenesis

(2017) Abhilash I. Chiramel et al.   VIRUS RESEARCH

Role of autophagy in the pathogenesis of inflammatory bowel disease

(2017) Tomoya Iida et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Harnessing Plant Biodiversity for the Discovery of Novel Anticancer Drugs Targeting Microtubules

(2017) Songbo Xie et al.   Frontiers in Plant Science

Autophagy induces apoptosis and death of T lymphocytes in the spleen of pigs infected with CSFV

(2017) Hongchao Gou et al.   Scientific Reports

Characterization of common carp (Cyprinus carpio L.) interferon regulatory factor 5 (IRF5) and its expression in response to viral and bacterial challenges

(2016) Yaoyao Zhu et al.   BMC Veterinary Research

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

(2016) Zhenyu Zhong et al.   CELL

Inflammatory Bowel Disease Drugs: A Focus on Autophagy

(2016) Kirsty M. Hooper et al.   Journal of Crohns & Colitis

Regulation of autophagy by Ca2+

(2016) Fang Sun et al.   TUMOR BIOLOGY

Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation

(2015) Ling-Yan Su et al.   Autophagy

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA

(2015) Wei Xie et al.   Autophagy

The role of the autophagy in myocardial ischemia/reperfusion injury

(2015) Sai Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

(2015) Ksenya Shchors et al.   CANCER CELL

Autophagy is involved in high glucose-induced heart tube malformation

(2015) Guang Wang et al.   CELL CYCLE

Transcriptional regulation of autophagy in RAS-driven cancers

(2015) Ravi K. Amaravadi   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Improves Palmitate-Induced ER Stress/NFκB Pathways Associated with Stimulating Autophagy in Adipocytes

(2015) Jiajing Yin et al.   MEDIATORS OF INFLAMMATION

Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

(2015) Jihoon Nah et al.   MOLECULES AND CELLS

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

Characterization of IgM-binding protein: A pIgR-like molecule expressed by intestinal epithelial cells in the common carp (Cyprinus carpio L.)

(2015) Fumiao Zhang et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice

(2014) Li-qing Weng et al.   ACTA PHARMACOLOGICA SINICA

The autophagy geneATG5plays an essential role in B lymphocyte development

(2014) Brian C. Miller et al.   Autophagy

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

(2014) M. Schiebler et al.   EMBO Molecular Medicine

Adaptive immune responses at mucosal surfaces of teleost fish

(2014) Jan H.W.M. Rombout et al.   FISH & SHELLFISH IMMUNOLOGY

Was low CO2 a driving force of C4 evolution: Arabidopsis responses to long-term low CO2 stress

(2014) Yuanyuan Li et al.   JOURNAL OF EXPERIMENTAL BOTANY

Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

(2014) Saurabh V. Laddha et al.   MOLECULAR CANCER RESEARCH

Expression of autophagy-related protein beclin-1 in malignant canine mammary tumors

(2013) Jing-Lan Liu et al.   BMC Veterinary Research

Fluorescence Tomography of Rapamycin-Induced Autophagy and Cardioprotection In Vivo

(2013) Howard H. Chen et al.   Circulation-Cardiovascular Imaging

Autophagy in the immune system

(2013) Daniel J. Puleston et al.   IMMUNOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats

(2013) K Sun et al.   Cell Death & Disease

Autophagy: an affair of the heart

(2012) Roberta A. Gottlieb et al.   HEART FAILURE REVIEWS

The contribution of autophagy to lymphocyte survival and homeostasis

(2012) Ian X. McLeod et al.   IMMUNOLOGICAL REVIEWS

Autophagy and Neuronal Cell Death in Neurological Disorders

(2012) R. A. Nixon et al.   Cold Spring Harbor Perspectives in Biology

Macroautophagy in T Lymphocyte Development and Function

(2012) Ming-Xiao He et al.   Frontiers in Immunology

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Autophagy Enhanced by Microtubule- and Mitochondrion-Associated MAP1S Suppresses Genome Instability and Hepatocarcinogenesis

(2011) R. Xie et al.   CANCER RESEARCH

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Golgi Apparatus-Localized Synaptotagmin 2 Is Required for Unconventional Secretion in Arabidopsis

(2011) Haiyan Zhang et al.   PLoS One

Age at onset in Huntington’s disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7

(2010) Silke Metzger et al.   HUMAN GENETICS

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

TRAF6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

(2010) C. S. Shi et al.   Science Signaling

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis

(2009) Mehrdad Alirezaei et al.   Autophagy

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

(2009) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in Ischemic Heart Disease

(2009) Åsa B. Gustafsson et al.   CIRCULATION RESEARCH

TOR-mediated autophagy regulates cell death inDrosophilaneurodegenerative disease

(2009) Tao Wang et al.   JOURNAL OF CELL BIOLOGY

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Autophagy in neurodegeneration and development

(2008) Ashley R. Winslow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic Efficacy of ABT-737, a Selective Inhibitor of BCL-2, in Small Cell Lung Cancer

(2008) C. L. Hann et al.   CANCER RESEARCH