Review
Cell Biology
Hanxiao Yin, Mingzheng Hu, Dengwen Li
Summary: The epidermis is a barrier in the outermost layer of the skin that protects against pathogens. Basal keratinocytes, acting as stem cells, are crucial for epidermal development and skin damage recovery. Understanding the molecular mechanism of basal keratinocytes in epidermal development and stratification is important for preventing and treating skin lesions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ana Lisica, Jonathan Fouchard, Manasi Kelkar, Tom P. J. Wyatt, Julia Duque, Anne-Betty Ndiaye, Alessandra Bonfanti, Buzz Baum, Alexandre J. Kabla, Guillaume T. Charras
Summary: Research shows that tissue tension plays a crucial role in the orientation of cell divisions, with decreased tension leading to out-of-plane divisions and increased tension helping to restore accurate in-plane cell divisions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Ana Lisica, Jonathan Fouchard, Manasi Kelkar, Tom P. J. Wyatt, Julia Duque, Anne-Betty Ndiaye, Alessandra Bonfanti, Buzz Baum, Alexandre J. Kabla, Guillaume T. Charras
Summary: The orientation of cell division plays a crucial role in determining cell fate, tissue shape, and tissue architecture. Divisions parallel to the epithelial plane sustain tissue expansion, while divisions perpendicular to the plane promote tissue stratification.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Amaris Guevara -Garcia, Matis Soleilhac, Nicolas Minc, Delphine Delacour
Summary: Epithelial cells play a key role in tissue organization in multicellular organisms. In developing epithelial tissues, cellular proliferation and differentiation are tightly regulated to ensure proper organ formation and function. This review focuses on the current understanding of cell division and regulatory mechanisms in the intestinal epithelial tissue, and their importance in developmental biology and physiopathology.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D. Simons, Hisham Bazzi
Summary: The study suggests that the orientation of cell division is linked to the stratification process of the skin epidermis, although it has less impact on epidermal differentiation in later stages. The data provide insights into tissue homeostasis and hyperproliferative diseases.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Veronica Gatti, Claudia Fierro, Mirco Compagnone, Veronica La Banca, Alessandro Mauriello, Manuela Montanaro, Stefano Scalera, Francesca De Nicola, Eleonora Candi, Francesco Ricci, Luca Fania, Gerry Melino, Angelo Peschiaroli
Summary: Delta Np63, a master regulator of epithelial biology, interacts with Senataxin (SETX) to sustain the expression of epidermal differentiation genes and regulate the differentiation of keratinocytes. SETX physically binds the p63 DNA-binding motifs present in early epidermal differentiation genes KRT1 and ZNF750, facilitating R-loop removal and promoting gene expression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Anthony Galenza, Paola Moreno-Roman, Yu-Han Su, Lehi Acosta-Alvarez, Alain Debec, Antoine Guichet, Jon-Michael Knapp, Caroline Kizilyaprak, Bruno M. Humbel, Irina Kolotuev, Lucy Erin O'Brien
Summary: Galenza et al. demonstrate that progeny of basal stem cells in the intestinal epithelium of adult Drosophila seamlessly integrate into a physiologically active barrier by gestating their future apical surface in a sheltering niche. They find that a transitional occluding junction creates a sublumenal niche where the differentiating cell develops a deep apical pit with microvilli-lined membrane, which is then integrated into the barrier through remodelling of the niche. This study highlights the importance of coordinating junctional remodelling with cell differentiation to ensure the integration of stem cell progeny into a functional epithelium without compromising barrier integrity.
NATURE CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Arad Soffer, Adnan Mahly, Krishnanand Padmanabhan, Jonathan Cohen, Orit Adir, Eidan Loushi, Yaron Fuchs, Scott E. Williams, Chen Luxenburg
Summary: This study identifies a novel regulator, BCAM, that guides self-organization (SO) in the developing epidermis by regulating apoptosis and epidermal architecture.
Article
Multidisciplinary Sciences
Sneha L. Koneru, Fu Xiang Quah, Ritobrata Ghose, Mark Hintze, Nicola Gritti, Jeroen Sebastiaan van Zon, Michalis Barkoulas
Summary: Research in Caenorhabditis elegans has shown that certain mutants, such as those with a null mutation in the fusogen eff-1, can introduce variability in the population of epidermal cells, particularly through uncoupling of cell fusion from the cell differentiation program. Despite mostly normal patterns, stochastic errors in seam cell division and differentiation can lead to changes in tissue structure, highlighting the importance of tissue homeostasis in suppressing phenotypic variability during development.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Gink N. Yang, Parinaz Ahangar, Xanthe L. Strudwick, Zlatko Kopecki, Allison J. Cowin
Summary: This study found that altering Flii affects the divisional orientation of EpSCs, influencing the formation and development of the epidermis and hair follicles. Flii(+/-) resulted in increased asymmetrical division of EpSCs, leading to more epidermal stratification, while Flii(Tg)(/Tg) led to increased symmetrical division of EpSCs, higher cell proliferation rate, thinner epidermis, but more hair follicles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Pia Polito, Grazia Marini, Michele Palamenghi, Elena Enzo
Summary: The epidermis is a protective tissue in the human body, consisting of proliferative basal cells and differentiating suprabasal layers. Understanding the molecular mechanisms and pathways involved in keratinocytes' organization and regeneration is crucial for therapeutic approaches. Single-cell techniques have identified disease-specific drivers and therapeutic targets, advancing personalized therapies. This review summarizes the latest findings on transcriptomic and epigenetic profiling of human epidermal cells under different skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Panpan Zhu, Pengfei Zheng, Xinlong Kong, Shuo Wang, Muqing Cao, Chengtian Zhao
Summary: This study reveals the important role of Rassf7a in spinal cord regeneration and neural progenitor cell proliferation after spinal cord injury. Rassf7a modulates spindle orientation and cell cycle progression to affect neurogenesis.
Review
Cell Biology
Tao Zhong, Xiaoxiao Gongye, Minglei Wang, Jinming Yu
Summary: Proper spindle orientation is crucial for cell fate determination and tissue morphogenesis. Various factors, including geometric, internal and external cues, regulate spindle orientation and abnormalities in these factors can lead to defects in organ functions and severe diseases. Establishing a precise model to elucidate the effects of spindle orientation alone could significantly enhance our understanding of this complex event.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Judit Danis, Mark Mellett
Summary: NLRs are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection, playing a critical role in the innate immune response. Functions and tissue expression of NLRs vary across species. Individual family members of NLRs are known to play important roles in the pathogenesis of skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dermatology
Victor Augusti Negri, Fiona M. Watt
Summary: This article discusses the existence of human epidermal stem cells and their clinical application in ex vivo expansion for tissue repair. It also mentions the increasing availability of single-cell RNA-sequencing datasets, which provides new opportunities for studying the nature of epidermal stem cells and testing in vitro experimental models.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
