Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1

Tyrosine hydroxylase down-regulation after loss of Abelson helper integration site 1 (AHI1) promotes depression via the circadian clock pathway in mice

(2018) Dongkai Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

(2016) Xuan Zhao et al.   CELL

Molecular modulators of the circadian clock: lessons from flies and mice

(2016) Lucia Mendoza-Viveros et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Circadian Clock and Human Health

(2016) Till Roenneberg et al.   CURRENT BIOLOGY

Quantitative proteomics identifies myoferlin as a novel regulator of A Disintegrin and Metalloproteinase 12 in HeLa cells

(2016) Yanqing Zhou et al.   Journal of Proteomics

The intricate dance of post-translational modifications in the rhythm of life

(2016) Arisa Hirano et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The intricate dance of post-translational modifications in the rhythm of life

(2016) Arisa Hirano et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth

(2016) Bo Yang et al.   Oncotarget

Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function

(2016) Guangsen Shi et al.   Cell Reports

Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover

(2016) Hung Thanh Nguyen et al.   Cell Discovery

USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock

(2016) Arisa Hirano et al.   PLoS One

Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells

(2015) Xiao-ou Hou et al.   ACTA PHARMACOLOGICA SINICA

La FAM fatale: USP9X in development and disease

(2015) Mariyam Murtaza et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock

(2015) Jason P. DeBruyne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein C-terminal enzymatic labeling identifies novel caspase cleavages during the apoptosis of multiple myeloma cells induced by kinase inhibition

(2015) Wenwen Duan et al.   PROTEOMICS

CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock

(2015) Teruya Tamaru et al.   PLOS BIOLOGY

Seizures Are Regulated by Ubiquitin-specific Peptidase 9 X-linked (USP9X), a De-Ubiquitinase

(2015) Lily Paemka et al.   PLoS Genetics

CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1

(2015) Xin Tong et al.   PLoS One

USP2 Regulates the Intracellular Localization of PER1 and Circadian Gene Expression

(2014) Yaoming Yang et al.   JOURNAL OF BIOLOGICAL RHYTHMS

The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor

(2014) Nicole C. Gossan et al.   NUCLEIC ACIDS RESEARCH

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

PER1 Phosphorylation Specifies Feeding Rhythm in Mice

(2014) Zhiwei Liu et al.   Cell Reports

A central role for ubiquitination within a circadian clock protein modification code

(2014) Katarina Stojkovic et al.   Frontiers in Molecular Neuroscience

The role of ubiquitin modification in the regulation of p53

(2013) Andreas K. Hock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

p53 regulates Period2 expression and the circadian clock

(2013) Takao Miki et al.   Nature Communications

CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila

(2012) W. Luo et al.   GENES & DEVELOPMENT

USP2a Protein Deubiquitinates and Stabilizes the Circadian Protein CRY1 in Response to Inflammatory Signals

(2012) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CircaDB: a database of mammalian circadian gene expression profiles

(2012) Angel Pizarro et al.   NUCLEIC ACIDS RESEARCH

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2

(2012) Y. Yang et al.   Biology Open

Circadian dysfunction in a mouse model of Parkinson's disease

(2011) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

The De-Ubiquitinylating Enzyme, USP2, Is Associated with the Circadian Clockwork and Regulates Its Sensitivity to Light

(2011) Heather Dehlin Scoma et al.   PLoS One

USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly

(2010) Delphine Théard et al.   EMBO JOURNAL

E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb 

(2010) L. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

MdmX is a substrate for the deubiquitinating enzyme USP2a

(2009) N Allende-Vega et al.   ONCOGENE

The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2

(2008) Kanae Ohsaki et al.   JOURNAL OF BIOCHEMISTRY

 -Catenin Induces  -TrCP-Mediated PER2 Degradation Altering Circadian Clock Gene Expression in Intestinal Mucosa of ApcMin/+ Mice

(2008) X. Yang et al.   JOURNAL OF BIOCHEMISTRY

Dual Modification of BMAL1 by SUMO2/3 and Ubiquitin Promotes Circadian Activation of the CLOCK/BMAL1 Complex

(2008) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY