CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1

A central role for ubiquitination within a circadian clock protein modification code

(2014) Katarina Stojkovic et al.   Frontiers in Molecular Neuroscience

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex

(2013) N. Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP2a Protein Deubiquitinates and Stabilizes the Circadian Protein CRY1 in Response to Inflammatory Signals

(2012) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRL4CDT2 Targets CHK1 for PCNA-Independent Destruction

(2012) J. Huh et al.   MOLECULAR AND CELLULAR BIOLOGY

CRL4–DDB1–VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10

(2012) Manpreet Kaur et al.   NUCLEIC ACIDS RESEARCH

CRL4Cdt2

(2011) Tarek Abbas et al.   CELL CYCLE

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions

(2011) Barbara Iovine et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Selective Ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G Ubiquitin-Conjugating Enzymes via the CRL4Cdt2 Ubiquitin Ligase Complex

(2011) E. Shibata et al.   MOLECULAR AND CELLULAR BIOLOGY

The circadian clock and metabolism: Figure 1

(2010) Oren Froy   CLINICAL SCIENCE

Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells

(2010) S. H. Choi et al.   GENES & DEVELOPMENT

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis

(2010) Masato Michishita et al.   GENES TO CELLS

Transcriptional Repressor E4-binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding

(2010) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation

(2010) Tarek Abbas et al.   MOLECULAR CELL

Ubiquitylation of the amino terminus of Myc by SCFβ-TrCP antagonizes SCFFbw7-mediated turnover

(2010) Nikita Popov et al.   NATURE CELL BIOLOGY

Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis

(2010) S. Yamaji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

CRL4s: the CUL4-RING E3 ubiquitin ligases

(2009) Sarah Jackson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Network Features of the Mammalian Circadian Clock

(2009) Julie E Baggs et al.   PLOS BIOLOGY

The Cullin 4B-Based UV-Damaged DNA-Binding Protein Ligase Binds to UV-Damaged Chromatin and Ubiquitinates Histone H2A

(2008) J. Guerrero-Santoro et al.   CANCER RESEARCH

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

A High-Throughput Assay for siRNA-Based Circadian Screens in Human U2OS Cells

(2008) Christopher Vollmers et al.   PLoS One