Molecular modulators of the circadian clock: lessons from flies and mice

The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway

(2016) Weiliang Jiang et al.   CANCER LETTERS

Chromatin remodeling effects on enhancer activity

(2016) Estela García-González et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Circadian Clock and Human Health

(2016) Till Roenneberg et al.   CURRENT BIOLOGY

miR-124 Regulates the Phase of Drosophila Circadian Locomotor Behavior

(2016) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

The mammalian circadian clock and its entrainment by stress and exercise

(2016) Yu Tahara et al.   Journal of Physiological Sciences

Post-transcriptional control of the mammalian circadian clock: implications for health and disease

(2016) Marco Preußner et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

GSK-3 and CK2 Kinases Converge on Timeless to Regulate the Master Clock

(2016) Deniz Top et al.   Cell Reports

NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators

(2016) Dominic Landgraf et al.   PLoS Genetics

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis

(2015) Michael J. Parsons et al.   CELL

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

Rhythmic control of mRNA stability modulates circadian amplitude of mousePeriod3mRNA

(2015) Sung-Hoon Kim et al.   JOURNAL OF NEUROCHEMISTRY

Association of the circadian factor Period 2 to p53 influences p53's function in DNA-damage signaling

(2015) Tetsuya Gotoh et al.   MOLECULAR BIOLOGY OF THE CELL

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

(2015) Ruifeng Cao et al.   NATURE NEUROSCIENCE

NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1

(2015) Lorena Aguilar-Arnal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1

(2015) Lorena Aguilar-Arnal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Changes in poly(A) tail length dynamics from the loss of the circadian deadenylase Nocturnin

(2015) Shihoko Kojima et al.   Scientific Reports

EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription

(2015) Weiwei Tao et al.   Scientific Reports

GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins

(2015) Neel Mehta et al.   Cell Reports

Daytime CLOCK Dephosphorylation Is Controlled by STRIPAK Complexes in Drosophila

(2015) Simonetta Andreazza et al.   Cell Reports

Drosophila TIM Binds Importin α1, and Acts as an Adapter to Transport PER to the Nucleus

(2015) A. Reum Jang et al.   PLoS Genetics

KPNB1 mediates PER/CRY nuclear translocation and circadian clock function

(2015) Yool Lee et al.   eLife

DEC2–E4BP4 Heterodimer Represses the Transcriptional Enhancer Activity of the EE Element in the Per2 Promoter

(2015) Shintaro Tanoue et al.   Frontiers in Neurology

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

(2014) Selma Masri et al.   CELL

MicroRNAs function as cis- and trans-acting modulators of peripheral circadian clocks

(2014) Vikram R. Shende et al.   FEBS LETTERS

CLOCK:BMAL1 is a pioneer-like transcription factor

(2014) J. S. Menet et al.   GENES & DEVELOPMENT

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

(2014) Rui Ye et al.   GENES & DEVELOPMENT

Glucagon-CREB/CRTC2 Signaling Cascade Regulates Hepatic BMAL1 Protein

(2014) Xiujie Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells

(2014) Tetsuya Gotoh et al.   MOLECULAR BIOLOGY OF THE CELL

Specificity in Circadian Clock Feedback from Targeted Reconstitution of the NuRD Corepressor

(2014) Jin Young Kim et al.   MOLECULAR CELL

Rhythmic U2af26 Alternative Splicing Controls PERIOD1 Stability and the Circadian Clock in Mice

(2014) Marco Preußner et al.   MOLECULAR CELL

Circadian behavior is light-reprogrammed by plastic DNA methylation

(2014) Abdelhalim Azzi et al.   NATURE NEUROSCIENCE

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

(2014) Hao A Duong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor

(2014) Nicole C. Gossan et al.   NUCLEIC ACIDS RESEARCH

Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling

(2014) Pin-Tse Lee et al.   NUCLEIC ACIDS RESEARCH

Regulation of Drosophila circadian rhythms by miRNA let-7 is mediated by a regulatory cycle

(2014) Wenfeng Chen et al.   Nature Communications

The MAP Kinase p38 Is Part of Drosophila melanogaster's Circadian Clock

(2014) Verena Dusik et al.   PLoS Genetics

The Proteomic Landscape of the Suprachiasmatic Nucleus Clock Reveals Large-Scale Coordination of Key Biological Processes

(2014) Cheng-Kang Chiang et al.   PLoS Genetics

Translational Regulation of the DOUBLETIME/CKIδ/ε Kinase by LARK Contributes to Circadian Period Modulation

(2014) Yanmei Huang et al.   PLoS Genetics

MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale

(2014) Ngoc-Hien Du et al.   eLife

O-GlcNAcylation of BMAL1 regulates circadian rhythms in NIH3T3 fibroblasts

(2013) Yan-Tao Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Egr1 regulates lithium-induced transcription of the Period 2 (PER2) gene

(2013) Se Hyun Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Long and Short of MicroRNA

(2013) Luke A. Yates et al.   CELL

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock

(2013) Aarti Jagannath et al.   CELL

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination

(2013) Min-Dian Li et al.   Cell Metabolism

miRNAs Are Required for Generating a Time Delay Critical for the Circadian Oscillator

(2013) Rongmin Chen et al.   CURRENT BIOLOGY

Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length

(2013) Peng Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clock and Light Regulation of the CREB Coactivator CRTC1 in the Suprachiasmatic Circadian Clock

(2013) K. Sakamoto et al.   JOURNAL OF NEUROSCIENCE

MicroRNA-185 oscillation controls circadian amplitude of mouse Cryptochrome 1 via translational regulation

(2013) Kyung-Ha Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Alternative cleavage and polyadenylation: extent, regulation and function

(2013) Ran Elkon et al.   NATURE REVIEWS GENETICS

Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by mTOR/4E-BP1 Signaling

(2013) Ruifeng Cao et al.   NEURON

Role of miR-142-3p in the Post-Transcriptional Regulation of the Clock Gene Bmal1 in the Mouse SCN

(2013) Vikram R. Shende et al.   PLoS One

Histone methyltransferase MLL3 contributes to genome-scale circadian transcription

(2013) Utham K. Valekunja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

(2013) D. Mauvoisin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATAXIN-2 Activates PERIOD Translation to Sustain Circadian Rhythms in Drosophila

(2013) C. Lim et al.   SCIENCE

A Role for Drosophila ATX2 in Activation of PER Translation and Circadian Behavior

(2013) Y. Zhang et al.   SCIENCE

p53 regulates Period2 expression and the circadian clock

(2013) Takao Miki et al.   Nature Communications

Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation

(2013) Yuting Liu et al.   Scientific Reports

Translational Profiling of Clock Cells Reveals Circadianly Synchronized Protein Synthesis

(2013) Yanmei Huang et al.   PLOS BIOLOGY

The CK2 Kinase Stabilizes CLOCK and Represses Its Activity in the Drosophila Circadian Oscillator

(2013) Áron Szabó et al.   PLOS BIOLOGY

The Circadian Clock Coordinates Ribosome Biogenesis

(2013) Céline Jouffe et al.   PLOS BIOLOGY

Clock-controlled mir-142-3p can target its activator, Bmal1

(2012) Xiaochao Tan et al.   BMC MOLECULAR BIOLOGY

Regulation of Circadian Behavioral Output via a MicroRNA-JAK/STAT Circuit

(2012) Wenyu Luo et al.   CELL

The RelB subunit of NFκB acts as a negative regulator of circadian gene expression

(2012) Marina M. Bellet et al.   CELL CYCLE

The Oscillating miRNA 959-964 Cluster Impacts Drosophila Feeding Time and Other Circadian Outputs

(2012) Sadanand Vodala et al.   Cell Metabolism

PML regulates PER2 nuclear localization and circadian function

(2012) Takao Miki et al.   EMBO JOURNAL

CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila

(2012) W. Luo et al.   GENES & DEVELOPMENT

A role for O-GlcNAcylation in setting circadian clock speed

(2012) E. Y. Kim et al.   GENES & DEVELOPMENT

Circadian control of mRNA polyadenylation dynamics regulates rhythmic protein expression

(2012) S. Kojima et al.   GENES & DEVELOPMENT

A quantitative atlas of polyadenylation in five mammals

(2012) Adnan Derti et al.   GENOME RESEARCH

The C-terminal Kinase and ERK-binding Domains ofDrosophilaS6KII (RSK) Are Required for Phosphorylation of the Protein and Modulation of Circadian Behavior

(2012) Michelle M. Tangredi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP2a Protein Deubiquitinates and Stabilizes the Circadian Protein CRY1 in Response to Inflammatory Signals

(2012) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Micro-Managing the Circadian Clock: The Role of microRNAs in Biological Timekeeping

(2012) Neel Mehta et al.   JOURNAL OF MOLECULAR BIOLOGY

Time of Day Regulates Subcellular Trafficking, Tripartite Synaptic Localization, and Polyadenylation of the Astrocytic Fabp7 mRNA

(2012) J. R. Gerstner et al.   JOURNAL OF NEUROSCIENCE

Natural Variation in the Drosophila melanogaster Clock Gene Period Modulates Splicing of Its 3′-Terminal Intron and Mid-Day Siesta

(2012) Kwang Huei Low et al.   PLoS One

PKC  participates in food entrainment by regulating BMAL1

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cold-Inducible RNA-Binding Protein Modulates Circadian Gene Expression Posttranscriptionally

(2012) J. Morf et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Regulation of alternative splicing by the circadian clock and food related cues

(2012) Nicholas J McGlincy et al.   GENOME BIOLOGY

A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation

(2011) Mary L. Spengler et al.   CELL CYCLE

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Cytoplasmic polyadenylation and translational control

(2011) Ana Villalba et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

An RNA-protein complex links enhanced nuclear 3′ processing with cytoplasmic mRNA stabilization

(2011) Xinjun Ji et al.   EMBO JOURNAL

The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila

(2011) Angélique Lamaze et al.   EMBO REPORTS

A Key Temporal Delay in the Circadian Cycle ofDrosophilaIs Mediated by a Nuclear Localization Signal in the Timeless Protein

(2011) Lino Saez et al.   GENETICS

Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability

(2011) Naval P. Shanware et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of thePeriod2Gene

(2011) Satoru Koyanagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of Doubletime Kinase-dependent Degradation of theDrosophilaPeriod Protein

(2011) Sheyum Syed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian Conformational Change of the Neurospora Clock Protein FREQUENCY Triggered by Clustered Hyperphosphorylation of a Basic Domain

(2011) Christina Querfurth et al.   MOLECULAR CELL

Mechanisms and Consequences of Alternative Polyadenylation

(2011) Dafne Campigli Di Giammartino et al.   MOLECULAR CELL

The novel gene twenty-four defines a critical translational step in the Drosophila clock

(2011) Chunghun Lim et al.   NATURE

Circadian regulation of mammalian target of rapamycin signaling in the mouse suprachiasmatic nucleus

(2011) R. Cao et al.   NEUROSCIENCE

Expression and Rhythmic Modulation of Circulating MicroRNAs Targeting the Clock Gene Bmal1 in Mice

(2011) Vikram R. Shende et al.   PLoS One

The De-Ubiquitinylating Enzyme, USP2, Is Associated with the Circadian Clockwork and Regulates Its Sensitivity to Light

(2011) Heather Dehlin Scoma et al.   PLoS One

A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits

(2011) E. S. Maywood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1

(2011) H.-m. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock

(2011) L. DiTacchio et al.   SCIENCE

A Molecular Mechanism for Circadian Clock Negative Feedback

(2011) H. A. Duong et al.   SCIENCE

AKT and TOR Signaling Set the Pace of the Circadian Pacemaker

(2010) Xiangzhong Zheng et al.   CURRENT BIOLOGY

miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock

(2010) Matías Alvarez-Saavedra et al.   HUMAN MOLECULAR GENETICS

CREB Influences Timing and Entrainment of the SCN Circadian Clock

(2010) Boyoung Lee et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Mammalian Target of Rapamycin Signaling Modulates Photic Entrainment of the Suprachiasmatic Circadian Clock

(2010) R. Cao et al.   JOURNAL OF NEUROSCIENCE

A Hierarchical Phosphorylation Cascade That Regulates the Timing of PERIOD Nuclear Entry Reveals Novel Roles for Proline-Directed Kinases and GSK-3 /SGG in Circadian Clocks

(2010) H. W. Ko et al.   JOURNAL OF NEUROSCIENCE

DYRK1A and Glycogen Synthase Kinase 3 , a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping

(2010) N. Kurabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

A methyl transferase links the circadian clock to the regulation of alternative splicing

(2010) Sabrina E. Sanchez et al.   NATURE

The histone methyltransferase MLL1 permits the oscillation of circadian gene expression

(2010) Sayako Katada et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation

(2010) Saurabh Sahar et al.   PLoS One

Light-Dependent Interactions between the Drosophila Circadian Clock Factors Cryptochrome, Jetlag, and Timeless

(2009) Nicolai Peschel et al.   CURRENT BIOLOGY

Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm

(2009) Young-Ji Na et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The miRNA-192/194 cluster regulates the Period gene family and the circadian clock

(2009) Remco Nagel et al.   FEBS Journal

Integration of microRNA miR-122 in hepatic circadian gene expression

(2009) D. Gatfield et al.   GENES & DEVELOPMENT

A role for microRNAs in the Drosophila circadian clock

(2009) S. Kadener et al.   GENES & DEVELOPMENT

The COP9 Signalosome Is Required for Light-Dependent Timeless Degradation and Drosophila Clock Resetting

(2009) A. Knowles et al.   JOURNAL OF NEUROSCIENCE

Ribosomal S6 Kinase Cooperates with Casein Kinase 2 to Modulate the Drosophila Circadian Molecular Oscillator

(2009) B. Akten et al.   JOURNAL OF NEUROSCIENCE

Circadian Amplitude of Cryptochrome 1 Is Modulated by mRNA Stability Regulation via Cytoplasmic hnRNP D Oscillation

(2009) K.-C. Woo et al.   MOLECULAR AND CELLULAR BIOLOGY

DOUBLETIME Plays a Noncatalytic Role To Mediate CLOCK Phosphorylation and Repress CLOCK-Dependent Transcription within the Drosophila Circadian Clock

(2009) W. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Induction of mPer1 expression by GnRH in pituitary gonadotrope cells involves EGR-1

(2009) H.E. Sikes Resuehr et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

(2009) Mo Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Fragile X-Related Proteins Regulate Mammalian Circadian Behavioral Rhythms

(2008) Jing Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Circadian regulation of a limited set of conserved microRNAs in Drosophila

(2008) Maocheng Yang et al.   BMC GENOMICS

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Organization of the Drosophila Circadian Control Circuit

(2008) Michael N. Nitabach et al.   CURRENT BIOLOGY

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock

(2008) J. C. Chiu et al.   GENES & DEVELOPMENT

The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2

(2008) Kanae Ohsaki et al.   JOURNAL OF BIOCHEMISTRY

Fragile X Mental Retardation Protein FMRP Binds mRNAs in the Nucleus

(2008) M. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Dual Modification of BMAL1 by SUMO2/3 and Ubiquitin Promotes Circadian Activation of the CLOCK/BMAL1 Complex

(2008) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock

(2008) Ruifeng Cao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Natural Variation in the Splice Site Strength of a Clock Gene and Species-Specific Thermal Adaptation

(2008) Kwang Huei Low et al.   NEURON

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

(2008) Qing-Jun Meng et al.   NEURON

Mouse period 2 mRNA circadian oscillation is modulated by PTB–mediated rhythmic mRNA degradation

(2008) Kyung-Chul Woo et al.   NUCLEIC ACIDS RESEARCH

Disturbed Clockwork Resetting in Sharp-1 and Sharp-2 Single and Double Mutant Mice

(2008) Moritz J. Rossner et al.   PLoS One