Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver

(2018) Fatemeh Hassani-Nezhad-Gashti et al.   BIOCHEMICAL PHARMACOLOGY

Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action

(2018) Susan P. Felter et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Aryl hydrocarbon receptor (AHR): “pioneer member” of the basic-helix/loop/helix per - Arnt - sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals

(2017) Daniel W. Nebert   PROGRESS IN LIPID RESEARCH

Transplacental exposure to environmental carcinogens: Association with childhood cancer risks and the role of modulating factors

(2017) A. Fucic et al.   REPRODUCTIVE TOXICOLOGY

Adverse outcome pathway development from protein alkylation to liver fibrosis

(2016) Tomislav Horvat et al.   ARCHIVES OF TOXICOLOGY

Regulation of hepatic energy metabolism by the nuclear receptor PXR

(2016) Jukka Hakkola et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine

(2016) Elena De Mattia et al.   PHARMACOGENOMICS

Impaired Glucose Tolerance in Healthy Men Treated with St. John's Wort

(2015) Tore Bjerregaard Stage et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Adverse Outcome Pathways and Drug-Induced Liver Injury Testing

(2015) Mathieu Vinken   CHEMICAL RESEARCH IN TOXICOLOGY

The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals

(2015) Jijing Tian et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Cytochrome P450 time-dependent inhibition and induction: advances in assays, risk analysis and modelling

(2015) Robert J Riley et al.   Expert Opinion on Drug Metabolism & Toxicology

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor

(2015) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor

(2015) Caitlin Lynch et al.   Scientific Reports

Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice

(2014) Krisstonia Spruiell et al.   BIOCHEMICAL PHARMACOLOGY

Pregnane X Receptor Agonists Impair Postprandial Glucose Tolerance

(2013) J Rysä et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

(2013) J. He et al.   DIABETES

PXR cross-talks with internal and external signals in physiological and pathophysiological responses

(2013) Susumu Kodama et al.   DRUG METABOLISM REVIEWS

Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice

(2013) Krisstonia Spruiell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Human cytochromes P450 in health and disease

(2013) D. W. Nebert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

(2013) Mathieu Vinken et al.   TOXICOLOGICAL SCIENCES

Flame Retardant BDE-47 Effectively Activates Nuclear Receptor CAR in Human Primary Hepatocytes

(2013) Tatsuya Sueyoshi et al.   TOXICOLOGICAL SCIENCES

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

(2013) Katie B. Paul et al.   TOXICOLOGY IN VITRO

Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals

(2013) AlberTinka J. Murk et al.   TOXICOLOGY IN VITRO

Pregnane X receptor- andCYP3A4-humanized mouse models and their applications

(2010) Jie Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

(2010) S. J. Shukla et al.   DRUG METABOLISM AND DISPOSITION

Hepatic Enzyme Induction

(2010) Robert R. Maronpot et al.   TOXICOLOGIC PATHOLOGY

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

(2009) B. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition and induction of human cytochrome P450 enzymes: current status

(2008) Olavi Pelkonen et al.   ARCHIVES OF TOXICOLOGY

CYP2B6: New Insights into a Historically Overlooked Cytochrome P450 Isozyme

(2008) Hongbing Wang et al.   CURRENT DRUG METABOLISM

The Roles of Nuclear Receptors CAR and PXR in Hepatic Energy Metabolism

(2008) Yoshihiro Konno et al.   Drug Metabolism and Pharmacokinetics