Pregnane X receptor- andCYP3A4-humanized mouse models and their applications

Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding

(2010) Monica A. Istrate et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel

(2010) Robert A.B. van Waterschoot et al.   INTERNATIONAL JOURNAL OF CANCER

A-kinase-interacting Protein 1 (AKIP1) Acts as a Molecular Determinant of PKA in NF-κB Signaling

(2010) Nan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pregnane X Receptor Is SUMOylated to Repress the Inflammatory Response

(2010) G. Hu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation

(2010) J. Cheng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Structural Basis of Pregnane X Receptor Binding Promiscuity

(2009) Chi-Ho Ngan et al.   BIOCHEMISTRY

Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity

(2009) R. A.B. van Waterschoot et al.   CANCER RESEARCH

Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

(2009) J. Cheng et al.   DRUG METABOLISM AND DISPOSITION

Cyclic AMP-dependent Protein Kinase Signaling Modulates Pregnane x Receptor Activity in a Species-specific Manner

(2009) Kristin Lichti-Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Regulation of Transcriptional Activity of Pregnane X Receptor by Protein Arginine Methyltransferase 1

(2009) Ying Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Aldo-Keto Reductase Akr1b7 Gene Is a Common Transcriptional Target of Xenobiotic Receptors Pregnane X Receptor and Constitutive Androstane Receptor

(2009) M.-J. Liu et al.   MOLECULAR PHARMACOLOGY

Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR

(2009) Sean Ekins et al.   PLoS Computational Biology

The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes

(2008) K. Lichti-Kaiser et al.   DRUG METABOLISM AND DISPOSITION

A Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4

(2008) X. Ma et al.   DRUG METABOLISM AND DISPOSITION

The pregnane X receptor: from bench to bedside

(2008) Xiaochao Ma et al.   Expert Opinion on Drug Metabolism & Toxicology

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response

(2008) Nico Scheer et al.   JOURNAL OF CLINICAL INVESTIGATION

Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists

(2008) S. Ekins et al.   MOLECULAR PHARMACOLOGY

Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4α interaction

(2008) Yun-Ping Lim et al.   Pharmacogenetics and Genomics

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY

The Antiapoptotic Role of Pregnane X Receptor in Human Colon Cancer Cells

(2007) Jie Zhou et al.   MOLECULAR ENDOCRINOLOGY

The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor

(2007) Hongwei Wang et al.   MOLECULAR ENDOCRINOLOGY