Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cells

Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis

(2018) Neeraj Vij et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy

(2016) Yunxiao Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure

(2016) Forrest Jessop et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma

(2016) Duy Le Pham et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium

(2015) Zhi-Hua Chen et al.   Autophagy

Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK

(2015) Jing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy and apoptosis in liver injury

(2015) Kewei Wang   CELL CYCLE

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

WNT/β-catenin signaling regulates cigarette smoke-induced airway inflammation via the PPARδ/p38 pathway

(2015) Lingli Guo et al.   LABORATORY INVESTIGATION

Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation

(2014) Yang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pim1 kinase protects airway epithelial cells from cigarette smoke-induced damage and airway inflammation

(2014) M. de Vries et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autophagic proteins regulate cigarette smoke induced apoptosis: Protective role of heme oxygenase-1

(2014) Hong Pyo Kim et al.   Autophagy

“Ciliophagy”

(2014) Suzanne M Cloonan et al.   Autophagy

Silymarin Attenuates Airway Inflammation Induced by Cigarette Smoke in Mice

(2014) Diandian Li et al.   INFLAMMATION

Identification of 23-(S)-2-Amino-3-Phenylpropanoyl-Silybin as an Antiviral Agent for Influenza A Virus InfectionIn VitroandIn Vivo

(2013) Jian-Ping Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

DAMPs and autophagy

(2013) Qiuhong Zhang et al.   Autophagy

Participation of autophagy in acute lung injury induced by seawater

(2013) Qiu-ping Liu et al.   EXPERIMENTAL LUNG RESEARCH

Silibinin protects murine fibroblast L929 cells from UVB-induced apoptosis through the simultaneous inhibition of ATM-p53 pathway and autophagy

(2013) Weiwei Liu et al.   FEBS Journal

Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

(2013) Hilaire C. Lam et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema

(2012) Chang Hyeok An et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Silibinin attenuates allergic airway inflammation in mice

(2012) Yun Ho Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation

(2012) C-P Chang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs

(2012) Kate Gaffey et al.   EUROPEAN RESPIRATORY JOURNAL

Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells

(2012) M. L. Mayer et al.   JOURNAL OF IMMUNOLOGY

Effect of Silymarin and Harpagoside on Inflammation Reaction of BEAS-2B Cells, on Ciliary Beat Frequency (CBF) of Trachea Explants and on Mucociliary Clearance (MCC)

(2012) Corinna Boeckenholt et al.   PLANTA MEDICA

A Comparison of the Inflammatory and Proteolytic Effects of Dung Biomass and Cigarette Smoke Exposure in the Lung

(2012) Divya Mehra et al.   PLoS One

Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

(2012) I. H. Lee et al.   SCIENCE

Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection

(2012) Y. Sun et al.   Science Signaling

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling

(2011) Jianhui Ma et al.   Journal of Genetics and Genomics

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD

(2010) Jae-woong Hwang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

(2010) Z.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells

(2009) Yan Cheng et al.   FEBS Journal

A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1

(2009) Jianrong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

(2008) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Silymarin, the Antioxidant Component of Silybum marianum, Prevents Sepsis-Induced Acute Lung and Brain Injury

(2008) Hale Z. Toklu et al.   JOURNAL OF SURGICAL RESEARCH

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

(2008) Zhi-Hua Chen et al.   PLoS One

Increased activation of p38 MAPK in COPD

(2007) T. Renda et al.   EUROPEAN RESPIRATORY JOURNAL