mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Future Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report

(2013) Timothy S. Blackwell et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCP-associated myopathy

(2013) James K. Ching et al.   Autophagy

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epithelial Pten Controls Acute Lung Injury and Fibrosis by Regulating Alveolar Epithelial Cell Integrity

(2012) Kahori Miyoshi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rapamycin treatment inhibits CHO cell death in a serum-free suspension culture by autophagy induction

(2012) Jae Seong Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

The Emerging Importance of Autophagy in Pulmonary Diseases

(2012) Kenji Mizumura et al.   CHEST

Management of epilepsy associated with tuberous sclerosis complex (TSC): Clinical recommendations

(2012) Paolo Curatolo et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons

(2012) Shi-Bing Yang et al.   NEURON

Rapamycin Ameliorates Kidney Fibrosis by Inhibiting the Activation of mTOR Signaling in Interstitial Macrophages and Myofibroblasts

(2012) Guochun Chen et al.   PLoS One

Heparin-Binding EGF-Like Growth Factor Induces Heart Interstitial Fibrosis via an Akt/mTor/p70s6k Pathway

(2012) Hong Lian et al.   PLoS One

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

Angiotensin II Activation of mTOR Results in Tubulointerstitial Fibrosis through Loss of N-Cadherin

(2011) Adam Whaley-Connell et al.   AMERICAN JOURNAL OF NEPHROLOGY

Autophagy

(2011) Jeffrey A. Haspel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes

(2011) Jianling Xie et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis

(2011) MONIQUE A. MALOUF et al.   RESPIROLOGY

Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis

(2010) Ayumi Yoshizaki et al.   ARTHRITIS AND RHEUMATISM

Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis

(2010) Eleonora Patsenker et al.   JOURNAL OF HEPATOLOGY

The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation

(2010) Edward K. Geissler et al.   KIDNEY INTERNATIONAL

mTOR Activation, Lymphangiogenesis, and Estrogen-Mediated Cell Survival: The “Perfect Storm” of Pro-Metastatic Factors in LAM Pathogenesis

(2010) Jane Yu et al.   Lymphatic Research and Biology

Prenatal Lung Epithelial Cell-Specific Abrogation of Alk3-Bone Morphogenetic Protein Signaling Causes Neonatal Respiratory Distress by Disrupting Distal Airway Formation

(2008) Jianping Sun et al.   AMERICAN JOURNAL OF PATHOLOGY