Cell death at the intestinal epithelial front line

Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD

(2015) M. Chopra et al.   BLOOD

Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis

(2015) Silvia von Karstedt et al.   CANCER CELL

Fas and TRAIL ‘death receptors’ as initiators of inflammation: Implications for cancer

(2015) Sean P. Cullen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death

(2015) Richard Hill et al.   Oncotarget

Should We Be Treating the Bugs instead of Cytokines and T Cells?

(2014) Eytan Wine   DIGESTIVE DISEASES

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Tumour Necrosis Factor Superfamily Members in the Pathogenesis of Inflammatory Bowel Disease

(2014) Tomasz J. Ślebioda et al.   MEDIATORS OF INFLAMMATION

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

Epithelial Cell Shedding and Barrier Function

(2014) J. M. Williams et al.   VETERINARY PATHOLOGY

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy

(2014) T Grabinger et al.   Cell Death & Disease

Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium

(2014) Tiago Nunes et al.   Biomed Research International

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Suppression of anoikis in human intestinal epithelial cells: differentiation state-selective roles of α2β1, α3β1, α5β1, and α6β4 integrins

(2013) Marco Beauséjour et al.   BMC CELL BIOLOGY

The Mucin Muc2 Limits Pathogen Burdens and Epithelial Barrier Dysfunction during Salmonella enterica Serovar Typhimurium Colitis

(2013) Maryam Zarepour et al.   INFECTION AND IMMUNITY

ERK controls epithelial cell death receptor signalling and cellular FLICE-like inhibitory protein (c-FLIP) in ulcerative colitis

(2013) Jakob Benedict Seidelin et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD

(2012) Tatiana Goretsky et al.   AMERICAN JOURNAL OF PATHOLOGY

TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function

(2012) Alastair J.M. Watson et al.   Annals of the New York Academy of Sciences

Tumor Suppression by p53: Fall of the Triumvirate?

(2012) Andreas K. Hock et al.   CELL

Regulation of intestinal epithelial permeability by tight junctions

(2012) Takuya Suzuki   CELLULAR AND MOLECULAR LIFE SCIENCES

The intestinal epithelium tuft cells: specification and function

(2012) François Gerbe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

(2012) Claudia Günther et al.   GUT

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

(2012) Kolja Schleich et al.   MOLECULAR CELL

Opposite Role of Tumor Necrosis Factor Receptors in Dextran Sulfate Sodium-Induced Colitis in Mice

(2012) Ke Wang et al.   PLoS One

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

(2012) X. Piao et al.   Science Signaling

Occludin is required for apoptosis when claudin–claudin interactions are disrupted

(2012) N Beeman et al.   Cell Death & Disease

Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells

(2011) Yanfang Guan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of CD95/Fas signaling at the DISC

(2011) I N Lavrik et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Enterocytes: active cells in tolerance to food and microbial antigens in the gut

(2011) N. Miron et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential expression of the TL1A/DcR3 system of TNF/TNFR-like proteins in large vs. small intestinal Crohn's disease

(2011) Giorgos Bamias et al.   DIGESTIVE AND LIVER DISEASE

p53 and PUMA Independently Regulate Apoptosis of Intestinal Epithelial Cells in Patients and Mice With Colitis

(2011) Ramanarao Dirisina et al.   GASTROENTEROLOGY

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

(2011) Amanda M. Marchiando et al.   GASTROENTEROLOGY

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

(2011) R Kiesslich et al.   GUT

Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells

(2011) Byong Hoon Yoo et al.   INTERNATIONAL JOURNAL OF CANCER

BCL-2 Modifying Factor (BMF) Is a Central Regulator of Anoikis in Human Intestinal Epithelial Cells

(2011) Martin Hausmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

(2011) Wei Qiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease

(2011) Rainer Noth et al.   Journal of Crohns & Colitis

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RIPK-Dependent Necrosis and Its Regulation by Caspases: A Mystery in Five Acts

(2011) Douglas R. Green et al.   MOLECULAR CELL

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival

(2011) Andrew Oberst et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

(2011) M. Roulis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-2 proteins and mitochondria—Specificity in membrane targeting for death

(2010) Jennefer Lindsay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Alternative cell death mechanisms in development and beyond

(2010) J. Yuan et al.   GENES & DEVELOPMENT

CD95 is cytoprotective for intestinal epithelial cells in colitis

(2010) Sun-Mi Park et al.   INFLAMMATORY BOWEL DISEASES

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL

(2010) Nicolai Fricker et al.   JOURNAL OF CELL BIOLOGY

Regulation of the Apaf-1-caspase-9 apoptosome

(2010) S. B. Bratton et al.   JOURNAL OF CELL SCIENCE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

(2010) P. Vandenabeele et al.   Science Signaling

Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid

(2010) S Schneider-Jakob et al.   Cell Death & Disease

Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

(2009) Andrea Haegebarth et al.   AMERICAN JOURNAL OF PATHOLOGY

TRAIL-Induced Apoptosis

(2009) Nadia Corazza et al.   Annals of the New York Academy of Sciences

Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function

(2009) Alastair J.M. Watson et al.   Annals of the New York Academy of Sciences

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling

(2009) A Wicovsky et al.   CELL DEATH AND DIFFERENTIATION

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

(2009) Thomas Kaufmann et al.   IMMUNITY

Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma

(2009) Chun Gao et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Differential expression of the TRAIL/TRAIL-receptor system in patients with inflammatory bowel disease

(2009) Sylvia Brost et al.   PATHOLOGY RESEARCH AND PRACTICE

RIP Kinases Initiate Programmed Necrosis

(2009) L. Galluzzi et al.   Journal of Molecular Cell Biology

p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter

(2008) Maciej Pietrzak et al.   BIOLOGICAL CHEMISTRY

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

(2008) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

Caspases — An update

(2008) Indrajit Chowdhury et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Functional characterisation of decoy receptor 3 in Crohn's disease

(2008) B Funke et al.   GUT

CD95 Stimulation Results in the Formation of a Novel Death Effector Domain Protein-containing Complex

(2008) Inna N. Lavrik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

To kill a tumor cell: the potential of proapoptotic receptor agonists

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Executioner caspase-3 and caspase-7 are functionally distinct proteases

(2008) J. G. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk of tight junction components with signaling pathways

(2007) Lorenza González-Mariscal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY