Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach

Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices

(2016) Suresh Vatakuti et al.   CHEMICAL RESEARCH IN TOXICOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices

(2015) Suresh Vatakuti et al.   TOXICOLOGY IN VITRO

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

(2015) Carmen G. Tag et al.   Jove-Journal of Visualized Experiments

Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease

(2014) Kazuhiko Bessho et al.   HEPATOLOGY

Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes

(2013) Ewa Szalowska et al.   BMC Medical Genomics

Human Precision-Cut Liver Slices as an ex Vivo Model to Study Idiosyncratic Drug-Induced Liver Injury

(2013) Mackenzie Hadi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The involvement of endoplasmic reticulum stress in bile acid-induced hepatocellular injury

(2013) Tetsuo Adachi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org

(2013) Lars M. T. Eijssen et al.   NUCLEIC ACIDS RESEARCH

Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

(2013) Mathieu Vinken et al.   TOXICOLOGICAL SCIENCES

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis

(2013) Sagnik Chatterjee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs

(2013) Inge M. Westra et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

(2012) J. Fraczek et al.   ARCHIVES OF TOXICOLOGY

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

(2012) Sébastien Anthérieu et al.   HEPATOLOGY

Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes

(2011) Eiichiro Ogimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver

(2011) A Schröder et al.   PHARMACOGENOMICS JOURNAL

Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes

(2011) M.G.L. Elferink et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

Oxidative Stress and the Pathogenesis of Cholestasis

(2010) Bryan Copple et al.   SEMINARS IN LIVER DISEASE

Tissue factor-dependent coagulation contributes to α-naphthylisothiocyanate-induced cholestatic liver injury in mice

(2009) James P. Luyendyk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

An In Vitro Assay to Assess Transporter-Based Cholestatic Hepatotoxicity Using Sandwich-Cultured Rat Hepatocytes

(2009) J. H. Ansede et al.   DRUG METABOLISM AND DISPOSITION

Rapid quantification of bile acids and their conjugates in serum by liquid chromatography–tandem mass spectrometry

(2009) Max Scherer et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

New molecular insights into the mechanisms of cholestasis

(2009) Martin Wagner et al.   JOURNAL OF HEPATOLOGY

Differential Modulation of Farnesoid X Receptor Signaling Pathway by the Thiazolidinediones

(2009) R. Kaimal et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ANIT-Induced Intrahepatic Cholestasis Alters Hepatobiliary Transporter Expression via Nrf2-Dependent and Independent Signaling

(2009) Yuji Tanaka et al.   TOXICOLOGICAL SCIENCES

Mechanisms of Cholestasis

(2008) Gernot Zollner et al.   Clinics in Liver Disease

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity

(2008) M ELFERINK et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY