Stress Responses of Bacterial Cells as Mechanism of Development of Antibiotic Tolerance (Review)

Stringent factor and proteolysis control of sigma factor RpoS expression in Vibrio cholerae

(2017) Philipp Wurm et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Peptide-nucleotide antibiotic Microcin C is a potent inducer of stringent response and persistence in both sensitive and producing cells

(2017) Julia Piskunova et al.   MOLECULAR MICROBIOLOGY

Antibiotic tolerance facilitates the evolution of resistance

(2017) Irit Levin-Reisman et al.   SCIENCE

Persisters—as elusive as ever

(2016) Niilo Kaldalu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

ATP synthase from Escherichia coli : Mechanism of rotational catalysis, and inhibition with the ε subunit and phytopolyphenols

(2016) Mayumi Nakanishi-Matsui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The cell envelope stress response of Bacillus subtilis: from static signaling devices to dynamic regulatory network

(2016) Jara Radeck et al.   CURRENT GENETICS

Persister formation in Escherichia coli can be inhibited by treatment with nitric oxide

(2016) Mehmet A. Orman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lineage-specific SoxR-mediated Regulation of an Endoribonuclease Protects Non-enteric Bacteria from Redox-active Compounds

(2016) Jisun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

(p)ppGpp and the bacterial cell cycle

(2016) Aanisa Nazir et al.   JOURNAL OF BIOSCIENCES

Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

(2016) Yingying Pu et al.   MOLECULAR CELL

Ribosome-dependent activation of stringent control

(2016) Alan Brown et al.   NATURE

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

Nascent peptide assists the ribosome in recognizing chemically distinct small molecules

(2016) Pulkit Gupta et al.   Nature Chemical Biology

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

(2016) Stefan Arenz et al.   NUCLEIC ACIDS RESEARCH

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones

(2016) Muhammad Malik et al.   NUCLEIC ACIDS RESEARCH

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

(2016) Rebecca M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal microbial evolution on antibiotic landscapes

(2016) M. Baym et al.   SCIENCE

Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics

(2016) Aurélie Mathieu et al.   Cell Reports

Unraveling the Physiological Complexities of Antibiotic Lethality

(2015) Daniel J. Dwyer et al.   Annual Review of Pharmacology and Toxicology

Microbial oxidative stress response: Novel insights from environmental facultative anaerobic bacteria

(2015) Huihui Fu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Persister Heterogeneity Arising from a Single Metabolic Stress

(2015) Stephanie M. Amato et al.   CURRENT BIOLOGY

Diversity in (p)ppGpp metabolism and effectors

(2015) Kuanqing Liu et al.   CURRENT OPINION IN MICROBIOLOGY

Diagnosing oxidative stress in bacteria: not as easy as you might think

(2015) James A Imlay   CURRENT OPINION IN MICROBIOLOGY

Modulation of protein synthesis by polyamines

(2015) Kazuei Igarashi et al.   IUBMB LIFE

Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell

(2015) Leonor Miller-Fleming et al.   JOURNAL OF MOLECULAR BIOLOGY

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

(2015) Natalie Verstraeten et al.   MOLECULAR CELL

HipBA–promoter structures reveal the basis of heritable multidrug tolerance

(2015) Maria A. Schumacher et al.   NATURE

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases

(2015) Elsa Germain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress sigma factor RpoS degradation and translation are sensitive to the state of central metabolism

(2015) Aurelia Battesti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

(2015) Peter Belenky et al.   Cell Reports

Tetracycline antibiotics and resistance mechanisms

(2014) Fabian Nguyen et al.   BIOLOGICAL CHEMISTRY

To divide or not to divide: control of the bacterial cell cycle by environmental cues

(2014) Kristina Jonas   CURRENT OPINION IN MICROBIOLOGY

ATP/ADP alteration as a sign of the oxidative stress development inEscherichia colicells under antibiotic treatment

(2014) Anna V. Akhova et al.   FEMS MICROBIOLOGY LETTERS

Putrescine controls the formation ofEscherichia colipersister cells tolerant to aminoglycoside netilmicin

(2014) Alexander G. Tkachenko et al.   FEMS MICROBIOLOGY LETTERS

Toxin-antitoxinvapBClocus participates in formation of the dormant state inMycobacterium smegmatis

(2014) Oksana I. Demidenok et al.   FEMS MICROBIOLOGY LETTERS

Elucidating the function of the RpoS regulon

(2014) Herb E Schellhorn   Future Microbiology

Fluoroquinolone-Gyrase-DNA Complexes

(2014) Arkady Mustaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

(2014) Ofer Fridman et al.   NATURE

Targeting of PBP1 by β-lactams Determines recA/SOS Response Activation in Heterogeneous MRSA Clinical Strains

(2014) Konrad B. Plata et al.   PLoS One

The Alternative Role of Enterobactin as an Oxidative Stress Protector Allows Escherichia coli Colony Development

(2014) Conrado Adler et al.   PLoS One

Crystal Structure of Penicillin-Binding Protein 3 (PBP3) from Escherichia coli

(2014) Eric Sauvage et al.   PLoS One

Identification of Novel Regulatory Small RNAs in Acinetobacter baumannii

(2014) Rajnikant Sharma et al.   PLoS One

Basic Regulatory Principles of Escherichia coli's Electron Transport Chain for Varying Oxygen Conditions

(2014) Sebastian G. Henkel et al.   PLoS One

Global Transcriptome and Physiological Responses of Acinetobacter oleivorans DR1 Exposed to Distinct Classes of Antibiotics

(2014) Aram Heo et al.   PLoS One

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IraL Is an RssB Anti-adaptor That Stabilizes RpoS during Logarithmic Phase Growth in Escherichia coli and Shigella

(2014) A. J. Hryckowian et al.   mBio

The 100S ribosome: ribosomal hibernation induced by stress

(2014) Hideji Yoshida et al.   Wiley Interdisciplinary Reviews-RNA

The role of metabolism in bacterial persistence

(2014) Stephanie M. Amato et al.   Frontiers in Microbiology

Superoxide-Mediated Protection of Escherichia coli from Antimicrobials

(2013) Michael Mosel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial Persister Cell Formation and Dormancy

(2013) Thomas K. Wood et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Microbial Persistence and the Road to Drug Resistance

(2013) Nadia R. Cohen et al.   Cell Host & Microbe

mazEF-mediated programmed cell death in bacteria: “What is this?”

(2013) Bhaskar Chandra Mohan Ramisetty et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Antibacterial action of quinolones: From target to network

(2013) Guyue Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metronidazole increases the emergence of ciprofloxacin- and amikacin-resistant Pseudomonas aeruginosa by inducing the SOS response

(2013) D. Hocquet et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Replication-Inhibited Unsegregated Nucleoid at Mid-Cell Blocks Z-Ring Formation and Cell Division Independently of SOS and the SlmA Nucleoid Occlusion Protein in Escherichia coli

(2013) J. Cambridge et al.   JOURNAL OF BACTERIOLOGY

Programmed Heterogeneity: Epigenetic Mechanisms in Bacteria

(2013) Josep Casadesús et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism of E. coli RNA Polymerase Regulation by ppGpp Is Suggested by the Structure of their Complex

(2013) Yuhong Zuo et al.   MOLECULAR CELL

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium

(2013) James A. Imlay   NATURE REVIEWS MICROBIOLOGY

Differential regulation by ppGpp versus pppGpp in Escherichia coli

(2013) Undine Mechold et al.   NUCLEIC ACIDS RESEARCH

Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase

(2013) Zeynep Baharoglu et al.   NUCLEIC ACIDS RESEARCH

Growth feedback as a basis for persister bistability

(2013) J. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

sigmaS, a major player in the response to environmental stresses inEscherichia coli: role, regulation and mechanisms of promoter recognition

(2013) Paolo Landini et al.   Environmental Microbiology Reports

RpoS Plays a Central Role in the SOS Induction by Sub-Lethal Aminoglycoside Concentrations in Vibrio cholerae

(2013) Zeynep Baharoglu et al.   PLoS Genetics

Role of Oxidative Stress in Persister Tolerance

(2012) Yanxia Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Medium-dependent control of the bacterial growth rate

(2012) Måns Ehrenberg et al.   BIOCHIMIE

Selection of resistance at lethal and non-lethal antibiotic concentrations

(2012) Diarmaid Hughes et al.   CURRENT OPINION IN MICROBIOLOGY

Antimicrobials as promoters of genetic variation

(2012) Jesús Blázquez et al.   CURRENT OPINION IN MICROBIOLOGY

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

(2012) Viktoriya Shyp et al.   EMBO REPORTS

Bacterial stress responses as determinants of antimicrobial resistance

(2012) K. Poole   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

H-NS Regulation of IraD and IraM Antiadaptors for Control of RpoS Degradation

(2012) A. Battesti et al.   JOURNAL OF BACTERIOLOGY

Signaling-mediated bacterial persister formation

(2012) Nicole M Vega et al.   Nature Chemical Biology

Regulation of the Escherichia coli HipBA Toxin-Antitoxin System by Proteolysis

(2012) Sonja Hansen et al.   PLoS One

Systems analysis of transcription factor activities in environments with stable and dynamic oxygen concentrations

(2012) M. D. Rolfe et al.   Open Biology

Impact of Ciprofloxacin Exposure on Staphylococcus aureus Genomic Alterations Linked with Emergence of Rifampin Resistance

(2011) Jean-Philippe Didier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Involvement of an ATP-Dependent Protease, PA0779/AsrA, in Inducing Heat Shock in Response to Tobramycin in Pseudomonas aeruginosa

(2011) Kristen N. Kindrachuk et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vibrio cholerae Triggers SOS and Mutagenesis in Response to a Wide Range of Antibiotics: a Route towards Multiresistance

(2011) Zeynep Baharoglu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bet hedging or not? A guide to proper classification of microbial survival strategies

(2011) Imke G. de Jong et al.   BIOESSAYS

Heterogeneous bacterial persisters and engineering approaches to eliminate them

(2011) Kyle R Allison et al.   CURRENT OPINION IN MICROBIOLOGY

Increase in cell viability by polyamines through stimulation of the synthesis of ppGpp regulatory protein and ω protein of RNA polymerase in Escherichia coli

(2011) Yusuke Terui et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyamines reduce oxidative stress in Escherichia coli cells exposed to bactericidal antibiotics

(2011) Alexander G. Tkachenko et al.   RESEARCH IN MICROBIOLOGY

The RpoS-Mediated General Stress Response inEscherichia coli

(2010) Aurelia Battesti et al.   Annual Review of Microbiology

Delineation of a Bacterial Starvation Stress Response Network Which Can Mediate Antibiotic Tolerance Development

(2010) D. K. C. Fung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

SOS involvement in stress-inducible biofilm formation

(2010) H. Gotoh et al.   BIOFOULING

The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

(2010) Nora Vázquez-Laslop et al.   EMBO JOURNAL

ppGpp is the major source of growth rate control in E. coli

(2010) Katarzyna Potrykus et al.   ENVIRONMENTAL MICROBIOLOGY

Metabolic and Transcriptional Response to Cofactor Perturbations in Escherichia coli

(2010) Anders K. Holm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thermodynamic Characterization of ppGpp Binding to EF-G or IF2 and of Initiator tRNA Binding to Free IF2 in the Presence of GDP, GTP, or ppGpp

(2010) Vladimir A. Mitkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

Contribution of rpoS and bolA genes in biofilm formation in Escherichia coli K-12 MG1655

(2010) Mohd Adnan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

Bacterial charity work leads to population-wide resistance

(2010) Henry H. Lee et al.   NATURE

Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

(2010) Tobias Dörr et al.   PLOS BIOLOGY

Conjugative DNA Transfer Induces the Bacterial SOS Response and Promotes Antibiotic Resistance Development through Integron Activation

(2010) Zeynep Baharoglu et al.   PLoS Genetics

Polyamines: fundamental characters in chemistry and biology

(2009) E. Agostinelli et al.   AMINO ACIDS

Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach

(2009) E. Agostinelli et al.   AMINO ACIDS

Role of reactive oxygen species in antibiotic action and resistance

(2009) Daniel J Dwyer et al.   CURRENT OPINION IN MICROBIOLOGY

Modulation of cellular function by polyamines

(2009) Kazuei Igarashi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Vibrio cholerae LexA Coordinates CTX Prophage Gene Expression

(2009) H. H. Kimsey et al.   JOURNAL OF BACTERIOLOGY

The Molecular Alarmone (p)ppGpp Mediates Stress Responses, Vancomycin Tolerance, and Virulence in Enterococcus faecalis

(2009) J. Abranches et al.   JOURNAL OF BACTERIOLOGY

The ArcBA Two-Component System of Escherichia coli Is Regulated by the Redox State of both the Ubiquinone and the Menaquinone Pool

(2009) M. Bekker et al.   JOURNAL OF BACTERIOLOGY

Growth Phase and (p)ppGpp Control of IraD, a Regulator of RpoS Stability, in Escherichia coli

(2009) H. Merrikh et al.   JOURNAL OF BACTERIOLOGY

Superoxide protects Escherichia coli from bleomycin mediated lethality

(2009) Richard M. Burger et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Structural Bases for 16 S rRNA Methylation Catalyzed by ArmA and RmtB Methyltransferases

(2009) Emmanuelle Schmitt et al.   JOURNAL OF MOLECULAR BIOLOGY

Oxidative Stress as a Trigger for Growth Phase-Specific σE-Dependent Cell Lysis in Escherichia coli

(2009) Rashed Noor et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Adaptive functions of Escherichia coli polyamines in response to sublethal concentrations of antibiotics

(2009) A. G. Tkachenko et al.   MICROBIOLOGY

Lysine decarboxylase activity as a factor of fluoroquinolone resistance in Escherichia coli

(2009) A. V. Akhova et al.   MICROBIOLOGY

ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor σEinEscherichia coliby both direct and indirect mechanisms

(2009) Alessandra Costanzo et al.   MOLECULAR MICROBIOLOGY

Programmed drug-dependent ribosome stalling

(2009) Haripriya Ramu et al.   MOLECULAR MICROBIOLOGY

Adaptive prediction of environmental changes by microorganisms

(2009) Amir Mitchell et al.   NATURE

A DNA damage response in Escherichia coli involving the alternative sigma factor, RpoS

(2009) H. Merrikh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Defenses against Superoxide and Hydrogen Peroxide

(2008) James A. Imlay   Annual Review of Biochemistry

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

Translational Attenuation and mRNA Stabilization as Mechanisms of erm(B) Induction by Erythromycin

(2008) Y.-H. Min et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The bacterial LexA transcriptional repressor

(2008) M. Butala et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Antibiotics as signals that trigger specific bacterial responses

(2008) Alicia Fajardo et al.   CURRENT OPINION IN MICROBIOLOGY

Bacteria Possessing Two RelA/SpoT-Like Proteins Have Evolved a Specific Stringent Response Involving the Acyl Carrier Protein-SpoT Interaction

(2008) A. Battesti et al.   JOURNAL OF BACTERIOLOGY

Protective Action of ppGpp in Microcin J25-Sensitive Strains

(2008) M. F. Pomares et al.   JOURNAL OF BACTERIOLOGY

Control of RpoS in global gene expression of Escherichia coli in minimal media

(2008) Tao Dong et al.   MOLECULAR GENETICS AND GENOMICS

A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli

(2008) Cecilia Unoson et al.   MOLECULAR MICROBIOLOGY

The global, ppGpp-mediated stringent response to amino acid starvation in Escherichia coli

(2008) Matthew F. Traxler et al.   MOLECULAR MICROBIOLOGY

A multifaceted role for polyamines in bacterial pathogens

(2008) Pratik Shah et al.   MOLECULAR MICROBIOLOGY

Predictive Behavior Within Microbial Genetic Networks

(2008) I. Tagkopoulos et al.   SCIENCE

Feedback control of ribosome function in Escherichia coli

(2007) H. Bremer et al.   BIOCHIMIE